| phase iii double-blind comparative study of fansimef and lariam for the curative treatment of plasmodium falciparum infections in thailand. | a double-blind comparative study of fanismef-mefloquine/sulfadoxine/pyrimethamine (msp) and lariam-mefloquine (mef) for the treatment of falciparum malaria, was carried out at malaria clinics in kanchanaburi, in western thailand, in the years 1987 and 1988. the cure rates obtained were 96% for the msp group and 93% for the mef and there was no significant difference. vomiting and diarrhea were common side effects in both the msp and mef groups. less common side effects were epigastric pain, mino ... | 1990 | 2075482 |
| electrophoretic variants of enzymes in isolates of plasmodium falciparum, p. malariae and p. vivax from thailand. | a new electrophoretic variant of glucose phosphate isomerase (gpi), which we now denote gpi-3, has been found in isolates of plasmodium falciparum from 6 patients, all of whom acquired the infection in the same region (in or near prachinburi province) of thailand. in other regions, from which 453 isolates have been tested, only gpi-1 and/or gpi-2 have been found. two isolates of p. malariae from patients at kanchanaburi showed a band of gpi activity on cellulose acetate gels at a cathodal positi ... | 1989 | 2694498 |
| investigation of malaria sporozoites by immunoradiometric assay. | two-site immunoradiometric assay (irma) (zavala et al., 1982) using monoclonal antibodies to p. falciparum and p. vivax was applied to detect sporozoites in laboratory-maintained an. dirus and also mosquitoes collected from endemic areas of malaria in thailand. study in p. falciparum infected mosquitoes revealed that the circumsporozoite (cs) antigen was first found in the abdominal portion on day 10 post-infection, while it could be observed in the salivary glands from day 15 onwards. the head- ... | 1988 | 3043705 |
| treatment of falciparum malaria with sulfalene-pyrimethamine versus sulfadoxine-pyrimethamine. | the study was carried out in 89 uncomplicated falciparum malaria adult cases admitted to paholpol-phayuhasena hospital, kanchanaburi province, thailand, during july 1979 and march 1980. the patients were divided alternatively into 2 groups. group i, 46 patients, were treated with a single dose of 1000 mg sulfalene and 50 mg pyrimethamine (2 tablets of metakelfin). group ii, 43 patients, were treated with 1000 mg sulfadoxine and 50 mg pyrimethamine (2 tablets of fansidar). the parasitemia was cle ... | 1980 | 7013094 |
| comparison between microscopic examination, elisa and quantitative buffy coat analysis in the diagnosis of falciparum malaria in an endemic population. | monoclonal antibody-based elisa and qbc (quantitative buffy coat analysis) were tested in two endemic areas with low and high incidence of malaria in kanchanaburi province, west thailand with annual parasite incidence in 1992 of 119 and 5 per 1,000 population, respectively. the numbers of individuals positive by thick blood film examination (tbf) for p. falciparum with or without p. vivax, and p. vivax only were 82 and 69, respectively. the detection limit of elisa was 10 parasites/10(6) red blo ... | 1995 | 8525418 |
| natural human igg subclass antibodies to plasmodium falciparum blood stage antigens and their relation to malaria resistance in an endemic area of thailand. | the immunoglobulin g (igg) subclass antibodies to plasmodium falciparum blood stage antigens in the sera of 181 individuals living in malaria endemic area in kanchanaburi province, western thailand, were determined by enzyme-linked immunosorbent assay (elisa). in this study, igg3 and igg1 were shown to be the predominant subclasses. generally, igg2 were coexpressed with igg1 and igg3 while igg4 was found to coexpress with other three igg subclasses. the levels of specific igg1, igg2, and igg3 in ... | 2001 | 11556572 |
| ige elevation and anti-plasmodium falciparum ige antibodies: association of high level with malaria resistance. | the total ige and anti-plasmodium falciparum ige antibodies were determined by enzyme linked immunosorbent assay (elisa) in 480 children and adults living in malaria endemic area along thai-myanmar border, kanchanaburi province, western thailand. approximately 73.13% of tested individuals had elevated levels of total ige with a range of 160-998 ng/ml. 20.5% of these ige were specific to p falciparum blood stage antigens, with a range of 78-353 microg/ml. however, the levels of total ige were not ... | 2001 | 12041541 |
| field evaluation of the ict malaria pf/pv immunochromatographic test for the detection of asymptomatic malaria in a plasmodium falciparum/vivax endemic area in thailand. | rapid antigen assays provide an effective tool for the detection of malaria in symptomatic patients. however, the efficacy of these devices for detecting asymptomatic malaria, where parasite levels are normally significantly lower than in symptomatic patients, is less well established. we evaluated the efficacy of a new combined plasmodium falciparum-plasmodim vivax immunochromatographic test (ict malaria pf/pv) in a cross-sectional malaria survey of the village of ban kong mong tha, kanchanabur ... | 2002 | 12164291 |
| variation of circumsporozoite 26 and 29 genotypes of plasmodium falciparum infecting patients and association with hla-dqa allotypes in western thailand. | we evaluated the proportion of variants of circumsporozoite protein (cp) gene 26 and cp29 antigenic epitopes of plasmodium falciparum infecting patients among 3 provinces in western thailand, in addition to published variants from gambia. the proportion of patients coinfected with cp26 and cp29 strains was significantly higher in patients reporting to malaria clinics in tak than in kanchanaburi and ratchaburi and higher in kanchanaburi than in ratchaburi. in western thailand, coinfection with cp ... | 2004 | 15040690 |
| malaria infection among the migrant population along the thai-myanmar border area. | a population based case-control study was performed to determine factors associated with malaria infection among the migrant population, foreign nationals aged 15 years or over. data were obtained from 217 malaria and 217 non-malaria patients attending the vector-borne disease control units 6-9 (thong pha phum and sangkhla buri districts) in kanchanaburi province and at the vector-borne disease control units 1,9 (mae fa luang and mae sai districts) in chiang rai province, between june and decemb ... | 2004 | 15272744 |
| declining mefloquine sensitivity of plasmodium falciparum along the thai-myanmar border. | mefloquine sensitivity of plasmodium falciparum along the thai-myanmar border, both in vitro and in vivo, following different first-line treatments for uncomplicated falciparum malaria patients in these areas during the period 1997--2003 were studied. standard in vitro micro tests and in vivo efficacy according to world health organization methodologies were performed. p. falciparum isolates along the thai-myanmar border with in vitro sensitivity to mefloquine have had up to a ten-fold decrease ... | 2004 | 15689066 |
| genetic diversity and population structure of plasmodium falciparum in thailand, a low transmission country. | the population structure of the causative agents of human malaria, plasmodium sp., including the most serious agent plasmodium falciparum, depends on the local epidemiological and demographic situations, such as the incidence of infected people, the vector transmission intensity and migration of inhabitants (i.e. exchange between sites). analysing the structure of p. falciparum populations at a large scale, such as continents, or with markers that are subject to non-neutral selection, can lead t ... | 2009 | 19602241 |