| low level genotypic chloroquine resistance near malawi's northern border with tanzania. | we conducted a prevalence study of mutations in plasmodium falciparum that are associated with antimalarial drug resistance at a rural site in karonga near malawi's northern border with tanzania. we found a higher prevalence of the key chloroquine resistance-conferring mutation in the pfcrt gene (k76t) at this site in comparison with the prevalence in blantyre, a city in the south of malawi, far from an international border (9%vs. 0%; p < 0.0005). in contrast we found a lower prevalence of the q ... | 2009 | 19624477 |
| high prevalence of quintuple mutant dhps/dhfr genes in plasmodium falciparum infections seven years after introduction of sulfadoxine and pyrimethamine as first line treatment in malawi. | malawi changed its national policy for malaria treatment in 1993, becoming the first country in africa to replace chloroquine by sulfadoxine and pyrimethamine combination (sp) as the first-line drug for uncomplicated malaria. seven years after this change, we investigated the prevalence of dihydropteroate synthase (dhps) and dihydrofolate reductase (dhfr) mutations, known to be associated with decreased sensitivity to sp, in 173 asymptomatic plasmodium falciparum infections from salima, malawi. ... | 2003 | 12659974 |
| efficacy of sulphadoxine/pyrimethamine for plasmodium falciparum malaria in malawian children under five years of age. | in march 1993, sulphadoxine/pyrimethamine (sp) replaced chloroquine as the first line drug for malaria treatment in malawi. since then, the ministry of health has been receiving anecdotal and written reports of sp treatment failures in children. to determine whether treatment failure with sp was a widespread problem, children < 5 years of age with axillary temperature > 38.0 degrees c and parasite density > 2000/mm3 attending the outpatient clinics of the mangochi and karonga district hospitals ... | 1996 | 8665390 |