| chloroquine-resistant plasmodium falciparum isolates from the sudan lack two mutations in the pfmdr1 gene thought to be associated with chloroquine resistance. | isolates of plasmodium falciparum from 3 areas of the sudan were recovered from cryopreservation in london and their chloroquine sensitivity was determined in vitro. chloroquine resistance was detected in 6/6 isolates from khartoum, 1/4 from sennar and 3/3 from gadarif, indicating that resistance is spreading. all the isolates were sensitive to mefloquine. studies using blood spots on glass fibre discs and the polymerase chain reaction did not detect two mutations in the pfmdr1 gene, thought to ... | 1992 | 1287907 |
| resistance to falciparum malaria among adults in central sudan. | adults claiming resistance to malaria were identified in the sennar region of central sudan, where p. falciparum is hyperendemic but seasonal in transmission. indirect fluorescent antibody (ifa) titers of sera from these individuals were comparable to those of malaria patients with positive blood films, indicating equal exposure, while in vitro antiparasitic activity of their sera tended to be higher, indicating an effective immunological response to falciparum malaria. hemoglobin s (hb s) was s ... | 1986 | 2936261 |
| use of the in vitro microtechnique for the assessment of drug sensitivity of plasmodium falciparum in sennar, sudan. | in 1978, studies on the chloroquine sensitivity of plasmodium falciparum were carried out in the district of sennar, sudan. the results of the in vivo tests showed parasites resistant at the ri level only, but the mean clearance time of trophozoites from the blood was higher than for strains found in many other areas of tropical africa. the in vitro tests, using the microtechnique, indicated a lower sensitivity to chloroquine in the local p. falciparum isolates than in those of most other africa ... | 1980 | 7028301 |
| descriptive study on the efficacy of artemether-lumefantrine in the treatment of uncomplicated plasmodium falciparum malaria in sudan. | the aim of this study was to investigate the efficacy of artemether-lumefantrine in treating uncomplicated plasmodium falciparum malaria in four sentinel areas in sudan with different malaria transmission (damazin, sinnar, and kosti in the north, and juba in the south). | 2010 | 20187287 |
| testing the sensitivity and specificity of the fluorescence microscope (cyscope) for malaria diagnosis. | early diagnosis and treatment of malaria are necessary components in the control of malaria. the gold standard light microscopy technique has high sensitivity, but is a relatively time-consuming procedure especially during epidemics and in areas of high endemicity. this study attempted to test the sensitivity and specificity of a new diagnostic tool - the cyscope fluorescence microscope, which is based on the use of plasmodium nucleic acid-specific fluorescent dyes to facilitate detection of the ... | 2010 | 20356369 |
| candidate malaria susceptibility/protective snps in hospital and population-based studies: the effect of sub-structuring. | populations of east africa including sudan, exhibit some of the highest indices of genetic diversity in the continent and worldwide. the current study aims to address the possible impact of population structure and population stratification on the outcome of case-control association-analysis of malaria candidate-genes in different sudanese populations, where the pronounced genetic heterogeneity becomes a source of concern for the potential effect on the studies outcome. | 2010 | 20459687 |
| dihydroartemisinin-piperaquine versus artemether-lumefantrine, in the treatment of uncomplicated plasmodium falciparum malaria in central sudan. | artemisinin-based combination therapies (act) are now being adopted as first-line treatments against uncomplicated malaria in sub-saharan africa. between december 2009 and february 2010, the efficacies of two act - dihydroartemisinin-piperaquine (dha-p) and artemether-lumefantrine (al) - in the treatment of uncomplicated plasmodium falciparum malaria were compared in sinnar, central sudan. overall, 149 patients (75 given dha-p and 74 given al) completed the 28 days of follow-up. all the patients ... | 2010 | 20659392 |
| comparison of artesunate and quinine in the treatment of sudanese children with severe plasmodium falciparum malaria. | sixty-six children presenting to singa hospital, sudan with different manifestations of severe plasmodium falciparum malaria were randomly divided into two well-matched groups (33 in each arm) to receive either intravenous artesunate 2·4 mg/kg at 0, 12, and 24 hours, then daily, or intravenous quinine 20mg/kg initially then 10mg/kg three times a day. there was no significant difference in the fever, parasite clearance, and coma resolution times. three patients died, one in the artesunate and two ... | 2010 | 20850004 |
| cytokine profiles in children with severe plasmodium falciparum malaria in an area of unstable malaria transmission in central sudan. | background: few data exist concerning pathogenesis of severe malaria in areas of unstable malaria transmission. objectives: the study was conducted in senga hospital, central sudan, which is characterized by unstable malaria transmission to investigate the cytokine profiles in children with severe plasmodium falciparum malaria. methods: enzyme-linked immunosorbent assay was used to measure the concentrations of three cytokines, interferon gamma (ifn-γ), interleukin-4 (il-4) and il-10, in sera of ... | 2010 | 21118871 |
| estimation of malaria transmission intensity in sennar state, central sudan. | understanding the behaviour of malaria vectors is crucial for planning mosquito control programmes. the aim of this study was to estimate the malaria transmission intensity in 2 different ecological zones in a highly endemic malaria area of sennar state in central sudan over the main transmission period. species confirmation by pcr indicated that anopheles arabiensis was the only malaria vector in the study area, with high anthropophilic behaviour (84.9% human-feeding). elisa studies showed plas ... | 2012 | 23057388 |