| composition and genetics of malaria vector populations in the central african republic. | in many african countries malaria has declined sharply due to a synergy of actions marked by the introduction of vector control strategies, but the disease remains a leading cause of morbidity and mortality in central african republic (car). an entomological study was initiated with the aim to characterize the malaria vectors in bangui, the capital of car, and determine their vector competence. | 2016 | 27456078 |
| polymorphisms in pfcrt, pfmdr1, dhfr genes and in vitro responses to antimalarials in plasmodium falciparum isolates from bangui, central african republic. | drug resistance is probably the greatest challenge to most malaria-control programs. given the limited resources for other malarial-control measures, rational drug used is crucial. molecular markers for parasite resistance such as pfcrt, pfmdr-1, and dhfr have the potential to be used in an integrated fashion to provide timely information that is useful to policy makers. therefore, we evaluated polymorphisms in these genes from plasmodium falciparum and their association with in vitro antimalari ... | 2006 | 16968910 |
| association of failures of seven-day courses of artesunate in a non-immune population in bangui, central african republic with decreased sensitivity of plasmodium falciparum. | we assessed the efficacy and safety of a seven-day course of artesunate for the treatment of uncomplicated plasmodium falciparum malaria in 55 non-immune patients living in bangui, central african republic. the parasitologic cure rates were 100%, 95%, and 85% on days 14, 28, and 42, respectively. there were no significant differences in parasitemia density, 50% inhibitory concentration of dihydroartemisinin, and frequency of mutant p. falciparum multidrug resistance 1 codon 86 between patients w ... | 2005 | 16172492 |
| [efficacy of artemether in the treatment of uncomplicated plasmodium falciparum malaria in children aged 6-60 months of age in bangui (central african republic)]. | transmission of malaria in the central african republic is holoendemic. the disease accounts for 40% of medical consultations and is the leading cause of morbidity and mortality. central african republic is classified by who in zone c for resistance to traditional anti-malaria drugs such as chloroquine, sulfadoxine-pyrimethamine, and amodiaquine. in this setting, our study sought to evaluate the therapeutic effectiveness and the feasibility (acceptability) of artemether in the treatment of uncom ... | 2008 | 18684692 |
| frequency distribution of antimalarial drug-resistant alleles among isolates of plasmodium falciparum in bangui, central african republic. | we determined the baseline frequency distribution of mutant alleles of genes associated with resistance to chloroquine and sulfadoxine-pyrimethamine in plasmodium falciparum isolates in bangui, central african republic. mutant alleles of the p. falciparum chloroquine resistance transporter (pfcrt) gene were found in all samples and the frequency of the deduced ciet pfcrt haplotype was high (45%). the most common allele of the p. falciparum multidrug resistance 1 (pfmdr1) gene among the field iso ... | 2006 | 16474071 |
| efficacy comparison between anti-malarial drugs in africans presenting with mild malaria in the central republic of africa: a preliminary study. | drug resistance to plasmodium falciparum contributes to major health problems in central africa and, as a consequence, poverty. we have analyzed the efficacy of three currently available antimalarial drugs to treat symptomatic, uncomplicated p. falciparum malaria in semi-immune adults living in bangui, central republic of africa. 210 consecutive individuals were enrolled in the survey, of which 45 were excluded. those having received dihydroartemisin proved significantly less parasitemic than th ... | 2005 | 15828586 |
| [pregnancy and blood parasite indices of plasmodium falciparum (results of a study in bangui (central african republic))]. | in bangui (c.a.r.), a comparative survey about infestation by plasmodium falciparum was carried out in 250 pregnant women and 250 non-pregnant women. both groups were matched by age, and none of them had taken any chemoprophylaxis or anti malarial treatment for the month before the survey. parasitic indices were significantly higher in pregnant women, and higher in primigravidae than multigravidae; the highest malarial indices were noted in the 15/20 age group. on the contrary, no significant di ... | 1987 | 3323770 |
| [status of drug resistance of plasmodium falciparum in the central african republic. results of studies carried out between 1984 and 1986]. | since august 1983, several cases of chloroquine resistant malaria have been observed in caucasian adults living in the central african republic (car) despite an antimalarial prophylaxis. between 1984 and 1985, several studies including both in vitro and in vivo tests have been undertaken in cohorts of children to determine antimalaria drug sensitivity of p. falciparum in two towns of the car. in bangui, out of 60 asymptomatic schoolchildren with asexual parasite count per mm3 of blood equal (or ... | 1987 | 3319251 |
| genetic diversity and genotype multiplicity of plasmodium falciparum infections in symptomatic individuals living in bangui (car). | this study provides the first estimate of the genetic diversity and genotype multiplicity of plasmodium falciparum infections in symptomatic individuals living in bangui (central african republic, car). three hundred thirty six clinical isolates were used for analysis of parasite population polymorphism and genotyped by nested-pcr of msp-1 block 2, and msp-2 block 3. we found a very high level of polymorphism, with, respectively, 17 and 25 different alleles at the msp-1 and msp-2 loci and a high ... | 2008 | 18501320 |
| drug-resistant malaria in bangui, central african republic: an in vitro assessment. | we used an in vitro isotopic drug sensitivity assay to assess the sensitivity of plasmodium falciparum isolates collected in bangui, central african republic between march and july 2004. we tested antimalarials that are currently in use in this country (chloroquine, amodiaquine, quinine, and pyrimethamine), antimalarials that will become available in this region in the future (artemisinin and halofantrine), and prophylactic antimalarials (mefloquine, doxycycline, and atovaquone). the proportions ... | 2005 | 16103582 |
| efficacy of chloroquine, amodiaquine, sulfadoxine-pyrimethamine, chloroquine-sulfadoxine-pyrimethamine combination, and amodiaquine-sulfadoxine-pyrimethamine combination in central african children with noncomplicated malaria. | this paper reports a two-phase study in bangui, central african republic (car): first, we assessed the clinical efficacy to chloroquine (cq), sulfadoxine-pyrimethamine (sp), and amodiaquine (aq), then we tested the efficacy of two combinations: cq + sp and aq + sp. we used the standard 14-day who 2001 protocol to compare therapeutic responses in children under 5 years of age with acute uncomplicated plasmodium falciparum malaria in bangui between february 2002 and march 2004. the overall treatme ... | 2005 | 15940847 |
| efficacy and safety of artemether + lumefantrine, artesunate + sulphamethoxypyrazine-pyrimethamine and artesunate + amodiaquine and sulphadoxine-pyrimethamine + amodiaquine in the treatment of uncomplicated falciparum malaria in bangui, central african republic: a randomized trial. | the efficacy of artemisinin-based combination therapy (act) has been established. the objective of the present study was to compare the efficacy and safety in the central african republic (car) of three commercially available artemisinin-based combinations, artemether + lumefantrine (al), artesunate + sulphamethoxypyrazine-pyrimethamine (as-smp) and artesunate + amodiaquine (as-aq), with those of sulphadoxine-pyrimethamine + amodiaquine (sp-aq), which was the first-line reference treatment in th ... | 2014 | 24393479 |
| [in vivo evaluation of chloroquine therapeutic efficacy in uncomplicated plasmodium falciparum malaria in central african republic ine 1997 and 1998]. | the efficacy of oral chloroquine was assessed in 268 children aged from 6 to 59 months attending pediatric services in regional hospitals between september 1997 and december 1998, located in the five county towns of the sanitary regions of the central african republic. chloroquine was prescribed at 25 mg per kg body weight, and administered over 3 days to patients suffering from uncomplicated malaria. body temperature and blood smears including parasitaemia were recorded on days 0, 3, 7 and 14. ... | 2003 | 12784590 |