| safety and immunogenicity of single-dose live oral cholera vaccine cvd 103-hgr in 5-9-year-old indonesian children. | oral vaccines offer great promise as public-health measures to prevent disease in less-developed countries. cvd 103-hgr, a genetically engineered, attenuated, vibrio cholerae o1 strain has proved effective in industrialised countries. we have assessed the safety, immunogenicity, and excretion of this live cholera vaccine in children in north jakarta, indonesia. 412 children aged 5-9 years received single doses of 5 x 10(6), 5 x 10(7), 5 x 10(8), 5 x 10(9), or 1 x 10(10) colony forming units (cfu ... | 1992 | 1355798 |
| safety, immunogenicity, and transmissibility of single-dose live oral cholera vaccine strain cvd 103-hgr in 24- to 59-month-old indonesian children. | recombinant a-b+ vibrio cholerae o1 strain cvd 103-hgr is a safe, highly immunogenic, single-dose live oral vaccine in adults in industrialized countries. safety, excretion, immunogenicity, vaccine transmissibility, and environmental introduction of cvd 103-hgr were investigated among 24- to 59-month-old children in jakarta. in 81 households, 1 child was randomly allocated a single dose of vaccine (5 x 10(9) cfu) and another, placebo. additionally, 139 unpaired children were randomly allocated v ... | 1993 | 8228350 |
| efficacy trial of single-dose live oral cholera vaccine cvd 103-hgr in north jakarta, indonesia, a cholera-endemic area. | a randomized, double-blind, placebo-controlled efficacy trial of one dose of cvd 103-hgr live oral cholera vaccine was performed in indonesia from 1993 to 1997. 67,508 persons aged 2-41 years ingested vaccine or placebo and were followed for four years, detecting cholera cases using hospital-based surveillance. a nested reactogenicity study (538 vaccinees, 535 controls) revealed no vaccine-attributable side effects. a nested immunogenicity study (n=657) showed vibriocidal seroresponses in 64-70% ... | 2000 | 10738097 |
| vibrio parahaemolyticus associated with cholera-like diarrhea among patients in north jakarta, indonesia. | a diarrhea study was conducted in north jakarta, indonesia from december 1996 through december 1997. vibrio parahaemolyticus was isolated from 333 (6.1%) of 5442 rectal swab samples collected from patients with cholera-like diarrhea. vibrio cholerae o1 was isolated from 545 (10.0%) and v. cholerae non-o1 from 183 samples (3.4%), respectively. patients positive for v. parahaemolyticus were mostly adults between 20 and 40 years of age, with males constituting 62%. a majority (65%) of these patient ... | 2001 | 11248518 |
| cholera in indonesia in 1993-1999. | cholera-specific surveillance in indonesia was initiated to identify the introduction of the newly recognized vibrio cholerae non-o1, o139 serotype. findings from seven years (1993-1999) of surveillance efforts also yielded regional profiles of the importance of cholera in both epidemic and sporadic diarrheal disease occurrence throughout the archipelago. a two-fold surveillance strategy was pursued involving 1) outbreak investigations, and 2) hospital-based case recognition. rectal swabs were t ... | 2001 | 11791976 |
| spectrum of vibrio species associated with acute diarrhea in north jakarta, indonesia. | vibrio spp was isolated from 1024 (21.2%) of 4820 diarrhea patients admitted to a community hospital in north jakarta from 1996 through 1998. vibrio cholerae o1 (49.5%) and v. parahaemolyticus (30.1%) comprised the major species isolated, followed by v. cholerae non-o1 (16.9%), and v. fluvialis (9.4%). in 938 (19.4%) patients, vibrio was found as single isolate. multiple infections were detected in 86 (1.8%) patients. a small number of v. furnisii, v. metschnikovii, v. mimicus and v. hollisae we ... | 2002 | 12088614 |
| enteropathogens associated with acute diarrhea in community and hospital patients in jakarta, indonesia. | the prevalence of bacteria, parasite and viral pathogens in 3875 patients with diarrhea in community and hospital settings from march 1997 through august 1999 in jakarta, indonesia was determined using routine bacteriology and molecular assay techniques. bacterial pathogens isolated from hospital patients were, in decreasing frequency, vibrio cholerae o1, shigella flexneri, salmonella spp. and campylobacter jejuni, while s. flexneri, v. cholerae o1, salmonella spp. and c. jejuni were isolated fr ... | 2002 | 12381465 |
| antimicrobial resistance of bacterial pathogens associated with diarrheal patients in indonesia. | the antimicrobial susceptibility patterns for 2,812 bacterial pathogens isolated from diarrheal patients admitted to hospitals in several provinces in the cities of jakarta, padang, medan, denpasar, pontianak, makassar, and batam, indonesia were analyzed from 1995 to 2001 to determine their changing trends in response to eight antibiotics: ampicillin, trimethoprim-sulfamethoxazole, chloramphenicol, tetracycline, cephalothin, ceftriaxone, norfloxacin, and ciprofloxacin. vibrio cholerae o1 (37.1%) ... | 2003 | 12887025 |
| edible ice in jakarta, indonesia, is contaminated with multidrug-resistant vibrio cholerae with virulence potential. | consumption of street food is considered a major health risk in the absence of public-health inspection programmes in indonesia. it is hypothesized that ice used in street food could be one of the major sources of vibrio cholerae contamination. this study documented v. cholerae contamination in edible ice from different areas of jakarta, the capital city of indonesia, and attempted to characterize the virulence potential of the strains. a selective medium was used to isolate 98 v. cholerae strai ... | 2012 | 23264457 |
| prevalence and molecular characterization of vibrio cholerae from ice and beverages sold in jakarta, indonesia, using most probable number and multiplex pcr. | vibrio cholerae is well recognized as the causative agent of cholera, an acute intestinal infection characterized by watery diarrhea that may lead to dehydration and death in some cases. v. cholerae is a natural inhabitant of the aquatic environment in the tropical regions. jakarta has the highest percentage of individuals affected by sporadic diarrheal illness compared with other areas in indonesia. inadequate safety measures for drinking water supplies, improper sanitation, and poor hygiene ca ... | 2012 | 22488052 |