Publications

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viruses and bacteria in pediatric diarrhea in thailand: a study of multiple antibiotic-resistant enteric pathogens.children with diarrhea admitted to a rehydration ward of a children's hospital in bangkok were investigated to determine the prevalence of enteric pathogens, the extent of children's previous antibiotic therapy, and the frequency of plasmid-mediated antibiotic resistance among infecting bacteria. rotavirus (36%), enterotoxigenic escherichia coli (18%), shigella (9%), salmonella (6%), campylobacter jejuni/coli (4%), and vibrio cholerae (2%) infections were among 105 children with diarrhea. antibi ...19816275727
cholera-like illness due to aeromonas sobria.a thai woman from bangkok was admitted to a hospital in paris for a cholera-like illness. a culture of her "rice-water" diarrhea was negative for vibrio cholerae and enterotoxigenic escherichia coli but was positive for aeromonas sobria. this strain produced enterotoxin, cytolysin, proteolysin, hemolysin, and a cell-rounding factor. acute -and convalescent-phase sera showed an increase in neutralizing antibodies to enterotoxin, cytolysin, and hemolysin. the enterotoxin, which was labile at 100 c ...19827054327
vibrio cholerae o139 bengal in bangkok. 19938101921
bacterial contamination of bottle milk in infants under 6 months in children's hospital, bangkok, thailand.the bacterial contamination of bottle milk samples obtained randomly from 500 infants under 6 months of age who came to the out-patient department of children's hospital bangkok was determined by collecting bottle milk samples prepared at home following interview of their caretakers after obtaining their consent. bacterial contamination was found in 91.8% (459/500) of bottle milk samples. among the positive samples, 82.8% (380/459) contained enteric bacteria, another 17.2% were unidentified bact ...199910928374
antibiotic prescription for adults with acute diarrhea at king chulalongkorn memorial hospital, thailand.in thailand, acute diarrhea is one of the most common problems among ambulatory patients at the outpatient department (opd). overuse of antibiotics is associated with increased rates of antibiotic-resistant bacteria, unnecessary increased cost of treatment, and significant incidence of adverse effects. in thailand, how frequently antibiotic is prescribed in adult patients with acute diarrhea is not known.201121675442
an acute gastroenteritis outbreak of vibrio parahaemolyticus o4:k55 in nursing college, thailand.a cluster of acute gastroenteritis among nursing students was noticed on 13th september 2005. between 13th and 17th september 2005, a retrospective cohort study was then conducted to identify the most likely cause of gastroenteritis at a nursing college in bangkok, thailand. self-administered questionnaires, interviews, environmental investigations, and rectal swabs from all participants were carried out. in the investigation, 98.9% female nursing students were investigated and had completed the ...201020962724
a high proportion of vibrio cholerae strains isolated from children with diarrhoea in bangkok, thailand are multiple antibiotic resistant and belong to heterogenous non-o1, non-o139 o-serotypes.results of a surveillance on cholera conducted with patients seen at the children hospital in bangkok, thailand from august 1993 to july 1995 are presented. annually, isolation rates for vibrio cholerae varied between 1.7 and 4.4% of patients with diarrhoea. v. cholerae o1 serotype ogawa accounted for between 31 and 47% of patients cultured positive for v. cholerae, whereas the o139 serotype dominated in early 1994 after which it disappeared. non-o1, non-0139 strains were isolated at similar rat ...199910355785
phenotypic and molecular characterization of vibrio cholerae o1 isolated in samutsakorn, thailand before, during and after the emergence of v. cholerae o139.seventy clinical strains of vibrio cholerae o1 isolated from 1982-96 in samutsakorn, a port city 30 km southwest of bangkok where cholera occurs at low levels with regular seasonality, were characterized to investigate if there were any differences among the o1 strains isolated before, during and after the 0139 epidemic. pulsed-field gel electrophoresis (pfge) typing, ribotyping and southern blot hybridization with a cholera toxin probe (ct genotyping) demonstrated several genotypes among o1 str ...19989825775
epidemiologic study of vibrio cholerae o1 and o139 in thailand: at the advancing edge of the eighth pandemic.vibrio cholerae o139 bengal emerged on the indian subcontinent in late 1992 and was first recognized in thailand in 1993. to characterize the epidemiology of this disease, a hospital-based case-control study was conducted in samutsakorn, a port city 30 km southwest of bangkok. between november 15, 1993, and june 3, 1994, 366 patients were confirmed to have cholera by culture, including 165 (45%) with o139 bengal, 191 (52%) with o1 ogawa, and 10 (3%) with both serogroups. during the same time per ...19968561160
vibrio parahaemolyticus: a major cause of travelers' diarrhea in bangkok.travelers' diarrhea in bangkok, thailand was investigated in a group of 146 hotel guests who had diarrhea during their stay in the city. the identified pathogenic organisms were vibrio parahaemolyticus in 45 (31%), vibrio cholerae in 1, nonagglutinable vibrio in 1, and entamoeba histolytica in 3. identification of enterotoxigenic escherichia coli was not attempted. the study suggests that vibrio parahaemolyticus is a major cause of travelers' diarrhea in bangkok.19827058975
vibrio cholerae o139 bengal infections among tourists to southeast asia: an intercontinental foodborne outbreak.to determine the source and extent of an outbreak of vibrio cholerae o139 bengal infections among 630 cruise ship passengers to southeast asia, a retrospective cohort study was done. questionnaires were sent to all passengers from the united states, canada, and the united kingdom, and serum samples were requested from all passengers reporting diarrhea. a case was defined as diarrheal illness with onset between 8 and 28 february 1994 and a cholera antitoxic antibody titer > or = 800. six passenge ...19957594688
a longitudinal study of the prevalence of bacterial enteric pathogens among adults with diarrhea in bangkok, thailand.six hundred sixty adults with diarrhea treated at bamrasnaradura hospital, bangkok, thailand were investigated to determine the prevalence, seasonality, and severity of diarrhea associated with bacterial enteric pathogens in 1980 and 1981. shigella were isolated from 27% and vibrio parahaemolyticus from 19% of the patients studied. enterotoxigenic escherichia coli (5%), salmonella (3%), non-01 vibrio cholerae (3%), campylobacter jejuni (1%), and group f vibrio (less than 1%) were isolated from a ...19836370564
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