| clinical and molecular analysis of haemoglobin h disease in sardinia: haematological, obstetric and cardiac aspects in patients with different genotypes. | in this study, 251 sardinian patients (187 adults and 64 children) with haemoglobin (hb) h disease were evaluated. two-hundred and sixteen patients (86%) had the deletional type (- -/-alpha) and 36 (14%) patients had the non-deletional type (- -/alpha(nd)alpha). a clear genotype-phenotype correlation was found, with the non-deletional type more severe than the deletional type. diagnosis of hb h disease was incidental in about 60% of cases. aplastic crises due to b19 parvovirus infection were fou ... | 2007 | 17129226 |