Publications

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efficiency of simulium sanctipauli as a vector of onchocerca volvulus in the forest zone of ghana.the role of simulium sanctipauli vajime & dunbar (diptera: simuliidae) as a vector of onchocerca volvulus (leuckart) (spirurida: onchocercidae) in the forest zone of central ghana was studied in the upper denkyira district, where onchocerciasis is hyperendemic. simulium sanctipauli was found to be a highly efficient vector, with a mean of 377 infective (l3) larvae in the heads of 1000 parous and 122 in the heads of 1000 biting flies. the overall infection rate of 44% of the parous flies with l1, ...200415189242
river blindness. protection for 54 cents a year.infection by onchocerca volvulus, a parasitic worm, causes onchocerciasis (river blindness), a debilitating and often blinding disease endemic to tropical areas of africa and central and south america. the adult onchocerca volvulus invades the human host where it lives and reproduces for up to 14 years, creating millions of infant worms which cause itching, loss of skin color, rapid aging, and disfiguring skin disease in the host. onchocerciasis often causes blindness in the human host by appr ...199812348635
the prevalence of onchocerciasis and other parasitic infestations on an oil palm plantation in ghana.this study was carried out amongst workers of twifo oil palm plantations (topp), a large agro-based industry located in the tropical rain forest belt of the central region of ghana in west africa. the district abounds in streams and rivers, the biggest being the rapidly flowing river pra which bisects the district. simulium flies abound in the area and are commonly seen biting voraciously especially during the period of the year when farm lands are being prepared for cropping. the author assumed ...200010902470
differential immune response to onchocerca volvulus: igg4 antibody responses differ in onchocerciasis patients from guatemala and ghana.geographical differences exist in the clinical features of onchocerciasis in central america and west africa, which could be due in part from variations in the antigenic composition of the infecting organism. in an attempt to address this question, adult female worms of onchocerca volvulus derived from nodules of patients from guatemala and ghana were compared in terms of polypeptide composition and the igg4 antibody responses induced in patients. it was shown that a tris-buffer soluble extract ...19979083582
discrimination between onchocerca volvulus and o. ochengi filarial larvae in simulium damnosum (s.l.) and their distribution throughout central ghana using a versatile high-resolution speciation assay.genetic surveillance of the human filarial parasite, onchocerca volvulus, from onchocerciasis endemic regions will ideally focus on genotyping individual infective larval stages collected from their intermediate host, simuliid blackflies. however, blackflies also transmit other onchocerca species, including the cattle parasite o. ochengi, which are difficult to distinguish from the human parasite based on morphological characteristics alone. this study describes a versatile approach to discrimin ...201627724959
genome-wide analysis of ivermectin response by onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity.treatment of onchocerciasis using mass ivermectin administration has reduced morbidity and transmission throughout africa and central/south america. mass drug administration is likely to exert selection pressure on parasites, and phenotypic and genetic changes in several onchocerca volvulus populations from cameroon and ghana-exposed to more than a decade of regular ivermectin treatment-have raised concern that sub-optimal responses to ivermectin's anti-fecundity effect are becoming more frequen ...201728746337
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