| a new puumala hantavirus subtype in rodents associated with an outbreak of nephropathia epidemica in south-east germany in 2004. | a micro-epidemic of hantavirus infections occurred in lower bavaria, south-east germany, starting in april 2004. while only three cases were registered from 2001 to 2003, a dramatically increased number of clinically apparent human hantavirus infections (n=38) was observed in 2004, plus seven additional cases by june 2005. to determine the reservoir responsible for the infections, a total of 43 rodents were trapped in lower bavaria. serological and genetic investigations revealed that puumala vi ... | 2006 | 16650330 |
| hantavirus disease outbreak in germany: limitations of routine serological diagnostics and clustering of virus sequences of human and rodent origin. | in europe, hemorrhagic fever with renal syndrome results mainly from infection with puumala virus (puuv) or dobrava virus. for 31 patients from a hantavirus disease outbreak in lower bavaria, a district in southeast germany, serodiagnosis was undertaken by enzyme-linked immunosorbent assay, immunofluorescence assay, and immunoblot analysis. in a few of these cases, however, puuv-specific typing of antibodies by these standard assays failed and a virus neutralization assay under biosafety level 3 ... | 2007 | 17626170 |
| network "rodent-borne pathogens" in germany: longitudinal studies on the geographical distribution and prevalence of hantavirus infections. | hantavirus infections are known in germany since the 1980s. while the overall antibody prevalence against hantaviruses in the general human population was estimated to be about 1-2%, an average of 100-200 clinical cases are recorded annually. in the years 2005 and 2007 in particular, a large increase of the number of human hantavirus infections in germany was observed. the most affected regions were located in the federal states of baden-wuerttemberg, bavaria, north rhine westphalia, and lower s ... | 2008 | 19030894 |
| seroepidemiological study in a puumala virus outbreak area in south-east germany. | puumala virus (puuv) is the cause of the majority of haemorrhagic fever with renal syndrome cases in germany. in 2004, a nephropathia epidemica outbreak was recorded in lower bavaria, south-east germany. for a seroepidemiological study in this region including the resident population at four locations (n = 178) and soldiers from one location (n = 208) indirect immunoglobulin m (igm) and immunoglobulin g (igg) enzyme-linked immunosorbent assays (elisas) and immunoblot tests based on a yeast-expre ... | 2009 | 19148676 |