| pseudomonas species contamination of cystic fibrosis patients' home inhalation equipment. | a prevalence study was undertaken to determine whether aerosol equipment used at home by patients with cystic fibrosis (cf) could provide a reservoir for pseudomonas aeruginosa or pseudomonas cepacia. home maintenance of this equipment was also evaluated for its relationship to contamination. in nine of 36 patients, pseudomonas species were isolated from one or more pieces of home equipment. only patients colonized with p. aeruginosa had contaminated equipment. p. aeruginosa was recovered from e ... | 1987 | 3612391 |
| linkage analysis of geographic and clinical clusters in pseudomonas cepacia infections by multilocus enzyme electrophoresis and ribotyping. | multilocus enzyme electrophoresis and ribotyping were used to characterize 83 strains of pseudomonas cepacia, mostly isolated from cystic fibrosis (cf) patients, although a number of isolates from non-cf nosocomial infections and reference environmental strains were represented. twenty enzyme electrophoretic types (ets) were determined; of these, one clone (et12) was associated with six of nine ribotypes (rts) said to be geographically representative of the united kingdom and all of the ontario ... | 1994 | 7517953 |
| cable (cbl) type ii pili of cystic fibrosis-associated burkholderia (pseudomonas) cepacia: nucleotide sequence of the cbla major subunit pilin gene and novel morphology of the assembled appendage fibers. | previous studies have shown that appendage pili of burkholderia cepacia strains isolated from patients with cystic fibrosis (cf) at the hospital for sick children, toronto, canada, mediate adherence to mucus glycoproteins and also enhance adherence to epithelial cells. the specific pilin-associated adhesin molecule is a 22-kda protein. in the present study we purified the major subunit pilin (17 kda) and immunolocalized it to peritrichously arranged pili. on the basis of their novel morphologica ... | 1995 | 7532166 |
| structurally variant classes of pilus appendage fibers coexpressed from burkholderia (pseudomonas) cepacia. | one or more of five morphologically distinct classes of appendage pili were determined to be peritrichously expressed by burkholderia (formerly pseudomonas) cepacia isolated from disparate sources. b. cepacia-encoded cbla pilin gene hybridization-based analysis revealed that one associated class, cable (cbl) adhesin type iib. cepacia pili, correlates with epidemically transmitted strains from a single cystic fibrosis (cf) center. when only phenotypic assays were available, correlations between t ... | 1995 | 7532167 |
| pseudomonas cepacia at summer camps for persons with cystic fibrosis. | pseudomonas cepacia (pc) is a multidrug-resistant, gram-negative bacillus that causes chronic colonization and infection of the respiratory tract of persons with cystic fibrosis (cf). pc colonization is usually difficult to eradicate with antimicrobial therapy and, in some patients, infection is associated with rapid decline in pulmonary function, increased hospitalization, and earlier death. previous studies have suggested person-to-person transmission of pc both within and outside of hospitals ... | 1993 | 7684813 |
| determinants of mortality from cystic fibrosis in canada, 1970-1989. | the frequency, prevalence, and mortality patterns of cystic fibrosis were analyzed in 3,795 patients documented in the canadian patient data registry in 1970-1989. cystic fibrosis frequency in the 1970-1979 birth cohort was virtually identical to the commonly quoted 1 in 2,500. in 1985-1989, median survival age was 36.7 years for males and 27.8 years for females, compared with 26.6 and 19.7, respectively, in 1970-1974. however, there were significant regional differences when canada was divided ... | 1996 | 8629607 |
| identification of is1356, a new insertion sequence, and its association with is402 in epidemic strains of burkholderia cepacia infecting cystic fibrosis patients. | burkholderia cepacia is now recognized as an important opportunistic pathogen in cystic fibrosis (cf) and other compromised patients. epidemicity among cf patients has been attributed to at least one particularly infectious strain (strain et12), and both genetic evidence and anecdotal evidence suggest that this strain, currently endemic in ontario, and those causing an epidemic in the united kingdom, are indeed the same. our study was conducted to determine whether there was any association betw ... | 1996 | 8784555 |
| pseudomonas aeruginosa and burkholderia cepacia infection in cystic fibrosis patients treated in toronto and copenhagen. | differences in the course of pulmonary disease in cystic fibrosis (cf) may be altered by different treatment strategies in different cf centers. the copenhagen clinic uses scheduled, regular and very aggressive treatment of lung infection. the toronto clinic treats pulmonary infection with oral, inhaled, or intravenous antibiotics, and has emphasized aggressive nutritional therapy. this study compared the clinical status of cf patients treated in the two centers (toronto, canada, n=302, and cope ... | 1998 | 9727758 |
| pregnancy in cystic fibrosis. fetal and maternal outcome. | to assess the effect of pregnancy on pulmonary function and survival in women with cystic fibrosis (cf) and to assess the fetal outcome. | 2000 | 10893364 |
| outbreak of burkholderia cepacia in the adult intensive care unit traced to contaminated indigo-carmine dye. | we report an unusual cluster of burkholderia cepacia in patients. environmental cultures identified indigo-carmine dye used in enteral feeding as the reservoir. compared with the controls, the cases were significantly more likely to have received tube feedings tinted with this dye. this outbreak was terminated with the removal of the dye from hospital inventory. | 2002 | 11893145 |
| epidemiology of burkholderia cepacia complex in patients with cystic fibrosis, canada. | the burkholderia cepacia complex is an important group of pathogens in patients with cystic fibrosis (cf). although evidence for patient-to-patient spread is clear, microbial factors facilitating transmission are poorly understood. to identify microbial clones with enhanced transmissibility, we evaluated b. cepacia complex isolates from patients with cf from throughout canada. a total of 905 isolates from the b. cepacia complex were recovered from 447 patients in 8 of the 10 provinces; 369 (83%) ... | 2002 | 11897071 |
| sustained endemicity of burkholderia cepacia complex in a pediatric institution, associated with contaminated ultrasound gel. | to determine whether contaminated ultrasound gel is the source of intermittent outbreaks of nosocomial infection due to burkholderia cepacia complex in patients without cystic fibrosis since 1992. | 2006 | 16622813 |
| survival of lung transplant patients with cystic fibrosis harboring panresistant bacteria other than burkholderia cepacia, compared with patients harboring sensitive bacteria. | the impact of panresistant bacteria, other than burkholderia cepacia, on the survival after lung transplantation in patients with cystic fibrosis (cf) remains controversial. | 2007 | 17692788 |
| incidence of deep vein thrombosis associated with peripherally inserted central catheters in adults with cystic fibrosis. | peripherally inserted central catheters (piccs) are commonly used in patients with cystic fibrosis (cf) to administer intravenous antibiotics for pulmonary exacerbations. the aim of this study was to determine the incidence of picc-related deep vein thrombosis (dvt) in a large group of adults with cf with and without burkholderia cepacia complex (bcc) infection, and to investigate the association between picc-related dvt and preinsertion serum erythrocyte sedimentation rate (esr). | 2009 | 19157904 |
| natural history of glucose intolerance in patients with cystic fibrosis: ten-year prospective observation program. | to determine prospectively the long-term natural history of glucose homeostasis in adult patients with cystic fibrosis (cf). | 2010 | 19962154 |