Publications

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in vitro activity of meropenem against common pathogenic bacteria isolated in taiwan.the in vitro antimicrobial activity of meropenem, in comparison with nine other antimicrobial agents, against 12 different common pathogenic bacteria were evaluated to know the susceptibility of common bacteria to meropenem in taiwan. meropenem was active against most gram-positive, gram-negative, and anaerobic bacteria, including methicillin-sensitive staphylococcus aureus, streptococcus pyogenes, enterococcus faecalis, escherichia coli, klebsiella pneumoniae, enterobacter cloacae, pseudomonas ...19989934544
in vitro activities of tigecycline, ertapenem, isepamicin, and other antimicrobial agents against clinically isolated organisms in taiwan.this study evaluated the in vitro activities of tigecycline, ertapenem, isepamicin, and other comparators against 861 bacterial isolates recovered from patients treated in three major teaching hospitals in 2003. mics to antimicrobial agents were determined by the agar dilution method. high rates of oxacillin resistance (58%) in staphylococcus aureus (60 isolates), and vancomycin resistance (21%) and quinupristin-dalfopristin non-susceptibility (39%) in enterococcus faecium (34 isolates) were fou ...200516359192
in vitro activities of doripenem and other carbapenems against clinically important bacteria isolated in intensive care units: nationwide data from the smart programme.this nationwide surveillance of clinically important bacteria from the intensive care units (icus) of major teaching hospitals throughout taiwan investigated the susceptibilities to doripenem and other comparator carbapenems from september through november 2005. minimum inhibitory concentrations (mics) were determined for 1,311 clinical isolates using the broth microdilution method according to clinical and laboratory standards institute (clsi) 2005 guidelines. doripenem showed similar (within f ...201020108018
carbapenem susceptibilities and non-susceptibility concordance to different carbapenems amongst clinically important gram-negative bacteria isolated from intensive care units in taiwan: results from the surveillance of multicentre antimicrobial resistance in taiwan (smart) in 2009.to investigate the in vitro susceptibilities to various carbapenems amongst clinical gram-negative bacteria isolated from patients in intensive care units of ten major teaching hospitals in taiwan in 2009, a survey was conducted to determine the minimum inhibitory concentrations (mics) of ertapenem, imipenem, meropenem and doripenem against isolates of enterobacteriaceae (n = 594), pseudomonas aeruginosa (n = 185), acinetobacter baumannii (n = 192) and burkholderia cepacia (n = 23) using the aga ...201323507415
nosocomial gram-negative bacteremia in critically ill patients: epidemiologic characteristics and prognostic factors in 147 episodes.although gram-positive organisms are the most common causes of nosocomial bloodstream infections, gram-negative bacteremia carries higher risks of severe sepsis, septic shock, and death among critically ill patients in intensive care units (icus). we performed a prospective epidemiologic analysis of nosocomial gram-negative bacteremia episodes among icu patients and sought to identify risk factors for mortality among these patients. all episodes of nosocomial gram-negative bacteremia documented ...199910462994
in vitro activities of antimicrobial agents, alone and in combinations, against burkholderia cepacia isolated from blood.burkholderia cepacia is a widespread, environmental gram-negative bacillus that is associated with nosocomial infections. this bacterium is considered to be an important pathogen in immunocompromised patients and is inherently resistant to multiple antimicrobial agents. to compare the activity of different antimicrobial agents and the potential of combinations against invasive strains of b. cepacia, we collected 36 isolates of b. cepacia from blood cultures and checked their susceptibilities to ...19979327247
comparison of the clinical efficacy between tigecycline plus extended-infusion imipenem and sulbactam plus imipenem against ventilator-associated pneumonia with pneumonic extensively drug-resistant acinetobacter baumannii bacteremia, and correlation of clinical efficacy with in vitro synergy tests.to compare the clinical efficacy between salvage antimicrobial regimen consisting of tigecycline plus extended-infusion imipenem/cilastatin (tic) and regimen of sulbactam plus imipenem/cilastatin (sic) for patients with ventilator-associated pneumonia and pneumonic bacteremia due to extensively drug-resistant (xdr) acinetobacter baumannii (ab) isolates, and determine the correlation of results of in vitro tigecycline-imipenem synergy test with clinical efficacy.201626341302
clinical characteristics and outcomes of patients with burkholderia cepacia bacteremia in an intensive care unit.the purpose of this study was to investigate a cohort of patients with burkholderia cepacia bacteremia in the intensive care unit (icu) at our institution. a large outbreak of b. cepacia bacteremia involving 95 patients lasted for 4 years in an icu in northern taiwan. the clinical characteristics and antimicrobial treatment responses of these patients were analyzed. minimal inhibitory concentrations were determined and pulse-field gel electrophoresis was performed for the 73 available isolates. ...201121392926
association between contaminated faucets and colonization or infection by nonfermenting gram-negative bacteria in intensive care units in taiwan.this study was designed to determine the strength of the association between the isolation of nonfermentative gram-negative bacilli (nfgnb) from tap water faucet aerators and the prevalence of colonization or infection of patients in intensive care units (icus). surveillance cultures were obtained during a 4-month period from 162 faucet aerators located in seven different icus. the prevalence of colonization or infection of icu patients with nfgnb was determined by prospective surveillance durin ...200919587299
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