Publications

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acute q fever hepatitis in taiwan.we report a case of a chronic hepatitis b carrier with an episode of acute hepatitis. the patient presented with a headache, arthralgias, jaundice and fever. while the laboratory tests mimicked chronic hepatitis b with an acute exacerbation, lipogranulomatous changes seen in the liver biopsy strongly suggested the presence of q fever. serology testing for coxiella burneti proved positive and the patient responded to tetracycline therapy. while previously unreported in taiwan, q fever is importan ...19957620101
acute q fever: first case report in taiwan.a 70-year-old retired fisherman presented with fever, chills and headache for four days. the clinical presentation was mild, including a self-limiting fever, pneumonia and elevated liver enzyme levels. acute q fever was proved by a four-fold rise of phase ii igg antibodies. interestingly, the man denied any animal contact or travelling over the past year. this case may suggest that q fever should be added to the list of differential diagnoses for acute febrile disease in taiwan.19937908577
q fever in taiwan.although q fever, a rickettsial disease caused by coxiella burnetii, is supposed to occur sporadically worldwide, there is only one case report of this disease in taiwan. we examined the antibody of q fever to evaluate the status of q fever in taiwan.19948087717
acute q fever as a cause of acute febrile illness of unknown origin in taiwan: report of seven cases.acute q fever, caused by coxiella burnetii has been well documented in western countries, but only recently identified in taiwan. seven cases diagnosed by indirect fluorescent antibodies to phase ii antigens of c. burnetii are reported. the patients were all men and a history of animal contact could be traced in most cases. clinical manifestations were high fever, chills, relative bradycardia and elevated serum aminotransferases. therapy with tetracycline or clarithromycin resulted in defervesce ...19979136520
seroprevalence of coxiella burnetii infection in southern taiwan.the emergence of infection with coxiella burnetii, the causative organism of q fever, has been only recently recognized in taiwan. several cases of acute q fever infection have been described, but the prevalence of antibodies to c. burnetii in the general population in taiwan has not been reported. thus, we studied the seroprevalence of c. burnetii infection in southern taiwan.200010743344
acute hepatitis with or without jaundice: a predominant presentation of acute q fever in southern taiwan.acute q fever was previously regarded as an uncommon infectious disease in taiwan but has been increasingly recognized recently. acute febrile illness, hepatitis, and pneumonia are the 3 most common manifestations of this condition, whereas jaundice is rarely reported among patients with acute q fever. we report 2 cases of acute q fever with jaundice and multi-organ involvement. the first patient presented with fever, severe headache, and acute abdomen necessitating laparotomy and was complicate ...200415181492
acute q fever: an emerging and endemic disease in southern taiwan.acute q fever is a worldwide zoonosis caused by coxiella burnetii infection. in taiwan, cases of acute q fever increased during 3 y of observation, especially at kaohsiung county and city in southern taiwan. from 15 april 2004 to 15 april 2007, a total of 67 cases of acute q fever were identified at e-da hospital located at kaohsiung county. 19 (28.4%) patients had a history of travel in rural areas and only 1 had been outside southern taiwan. 21 (31.3%) patients had a history of animal contact. ...200817852909
molecular detection and characterization of spotted fever group rickettsiae in taiwan.rickettsioses are emerging infectious diseases caused by rickettsiae in association with arthropods. we report the detection of spotted fever group rickettsiae (sfgr) in taiwan using molecular methods. phylogenetic analyses of the 17-kd protein and citrate synthase (glta) genes showed that sfgr twkm01 detected in rhipicephalus haemaphysaloides ticks was most similar to rickettsia rhipicephali. three twkm01 isolates were obtained from three individual r. haemaphysaloides ticks. small, intracellul ...200717984347
clinical prediction of endemic rickettsioses in northern taiwan--relevance of peripheral blood atypical lymphocytes.several rickettsioses are endemic in taiwan. they are under-reported not only because of ignorance but also due to difficulty in recognition caused by their nonspecific manifestations, which overlap with other acute febrile illnesses. we conducted a retrospective study to delineate distinctive clinical features of rickettsiosis, in order to develop a system for differential diagnosis of rickettsiosis.200819122916
acute q fever and scrub typhus, southern taiwan.acute q fever and scrub typhus are zoonoses endemic to southern taiwan. among the 137 patients with acute q fever (89, 65.0%) or scrub typhus (43, 31.4%), we identified 5 patients (3.6%) who were co-infected with coxiella burnetii and orientia tsutsugamushi.200919861068
identification of risk factors of coxiella burnetii (q fever) infection in veterinary-associated populations in southern taiwan.the first case of q fever in taiwan was reported in 1993. the disease is considered to be emerging in taiwan, but the route of transmission has remained unclear. the annual number of confirmed q fever cases has been increasing up to more than 100 cases since 2005, comparing with less than 30 before 2003. the purpose of this study was to determine the seroprevalence and risk factors of coxiella burnetii infection in veterinary-associated populations in southern taiwan. a total of 228 serum sample ...201019968850
clinical characteristics of q fever and etiology of community-acquired pneumonia in a tropical region of southern taiwan: a prospective observational study.the clinical characteristics of q fever are poorly identified in the tropics. fever with pneumonia or hepatitis are the dominant presentations of acute q fever, which exhibits geographic variability. in southern taiwan, which is located in a tropical region, the role of q fever in community-acquired pneumonia (cap) has never been investigated.201425033402
association of human q fever with animal husbandry, taiwan, 2004-2012.in taiwan, q fever cases in humans began increasing in 2004 and peaked in 2007 but dramatically declined in 2008 and 2011. cases were significantly correlated with the number of goats. the decline might be associated with the collateral effects of measures to control goat pox in 2008 and 2010.201526583537
human spotted fever group rickettsioses are underappreciated in southern taiwan, particularly for the species closely-related to rickettsia felis.despite increased identification of spotted fever group rickettsioses (sfgr) in animals and arthropods, human sfgr are poorly characterized in taiwan.201424755560
the epidemiology and characteristics of q fever and co-infections with scrub typhus, murine typhus or leptospirosis in taiwan: a nationwide database study.q fever (qf) is a worldwide zoonosis associated with outbreaks. only a few nationwide studies regarding the surveillance and epidemiology of human qf have been reported. although qf is endemic in taiwan, a nationwide database investigation of the epidemiology and characteristics of qf and its associations with scrub typhus (st), murine typhus (mt) and leptospirosis (ls) has never been reported. we analysed nationwide databases of suspected qf, st, mt and ls cases from october 2007 to december 20 ...201627966835
identification of factors for physicians to facilitate early differential diagnosis of scrub typhus, murine typhus, and q fever from dengue fever in taiwan.dengue fever, rickettsial diseases, and q fever are acute febrile illnesses with similar manifestations in tropical areas. early differential diagnosis of scrub typhus, murine typhus, and q fever from dengue fever may be made by understanding the distinguishing clinical characteristics and the significance of demographic and weather factors.201725648664
q fever outbreak in a small village, taiwan. 201020495278
epidemiology of acute q fever, scrub typhus, and murine typhus, and identification of their clinical characteristics compared to patients with acute febrile illness in southern taiwan.in taiwan, acute q fever, scrub typhus, and murine typhus (qsm diseases) are the most common rickettsioses, but their epidemiology and clinical characteristics have not been clarified. diagnosis of these three diseases based on clinical manifestations is difficult, and most of their reported characteristics are identified by describing the predominant manifestations, without being compared with other diseases.200919443290
the difference in clinical characteristics between acute q fever and scrub typhus in southern taiwan.to identify the differences in clinical characteristics between acute q fever and scrub typhus in southern taiwan.200918977677
clinical characteristics of acute q fever, scrub typhus, and murine typhus with delayed defervescence despite doxycycline treatment.doxycycline is the recommended antibiotic for acute q fever, scrub typhus, and murine typhus and defervescence often occurs within 3 days of treatment. patients with delayed defervescence (> 3 days) are troublesome for clinicians. to investigate the characteristics of such patients, 18 and 88 cases with and without delayed defervescence, respectively, were studied. by univariate analysis, absence of headache (p = 0.004), jaundice (p = 0.030), icteric sclera (p = 0.030), relative bradycardia (p = ...200818784240
acute q fever in southern taiwan: atypical manifestations of hyperbilirubinemia and prolonged fever.the clinical information of acute q fever in taiwan was limited. a clinical study of 109 adults with serologically documented acute q fever in the past decade (1994-2005) at 3 referral hospitals in southern taiwan was reported. their clinical manifestations, laboratory findings, and clinical outcomes were analyzed. males predominated (98, 90%). there is a significant correlation between monthly average temperature and case numbers of acute q fever (r = 0.74, p = 0.006). fever (99%), chills (69%) ...200817949935
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