Publications

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the etiologic and epidemiologic spectrum of bronchiolitis in pediatric practice.to develop a broad understanding of the causes and patterns of occurrence of wheezing associated respiratory infections, we analyzed data from an 11-year study of acute lower respiratory illness in a pediatric practice. although half of the wari occurred in children less than 2 years of age, wheezing continued to be observed in 19% of children greater than 9 years of age who had lower respiratory illness. males experienced lri 1.25 times more often than did females; the relative risk of males fo ...1979448557
epidemiology of respiratory syncytial virus in various regions within north carolina during multiple seasons.the centers for disease control and prevention (cdc) monitors the occurrence of respiratory syncytial virus (rsv) in the united states and has historically reported on activity at the regional level. prior to the 2007-2008 rsvseason, the cdc did not report seasonal rsv data for cities within north carolina or for the state. the purpose of the present study is to characterize rsv seasonal activity within north carolina and to determine the appropriate months in which at-risk children should recei ...200819256181
evaluation of a novel web-based prior approval application for palivizumab prophylaxis of respiratory syncytial virus in a state medicaid program.recent disproportionate increases in use of specialty medications, such as palivizumab (synagis), compared with steady utilization of traditional medication use, have prompted complex utilization management strategies that require frequent evaluation to facilitate cost-effectiveness while preserving patient access. clinical criteria utilized by north carolina (nc) medicaid for use of palivizumab for respiratory syncytial virus (rsv) prophylaxis are consistent with the most recent guidelines publ ...201323461427
respiratory syncytial virus outbreak in a long-term care facility detected using reverse transcriptase polymerase chain reaction: an argument for real-time detection methods.to report an outbreak of respiratory synctyial virus (rsv) in a long-term care facility (ltcf) during ongoing routine respiratory illness surveillance.200919187415
direct cost analyses of palivizumab treatment in a cohort of at-risk children: evidence from the north carolina medicaid program.use of palivizumab prophylactic therapy reduces the occurrence of hospitalizations for serious respiratory syncytial virus (rsv) lower respiratory tract infections in at-risk infants. the direct cost-benefit of palivizumab prophylaxis for infants who are born at 32 to 35 weeks' estimated gestational age (ega) during their first year of life has not been systematically examined. the objective of this study was to compare the direct costs of palivizumab prophylaxis and rsv treatment in infants who ...200415574623
nosocomial respiratory syncytial virus: a threat in the modern neonatal intensive care unit. 200212032794
risk factors for higher cost in congenital heart operations.for many congenital heart defects, hospital mortality is no longer a sensitive parameter by which to measure outcome. although hospital survival rates are now excellent for a wide variety of lesions, many patients require expensive and extensive hospital-based services during the perioperative period to enable their convalescence. these services can substantially increase the cost of care delivery. in today's managed care environment, it would be useful if risk factors for higher cost could be i ...19979236333
the epidemiology of tracheobronchitis in pediatric practice.epidemiologic characteristics of childhood tracheobronchitis occurring over a 104-month period in chapel hill, nc, were ascertained and compared to those of other pediatric lower respiratory illness (lri) syndromes. tracheobronchitis accounted for 40% of all lri seen at the community's only pediatric practice. tracheobronchitis incidence was highest during the first two years of life, through the ratio of tracheobronchitis incidence to total lri incidence increased with age. a viral pathogen or ...19816797294
respiratory-syncytial-virus infections, reinfections and immunity. a prospective, longitudinal study in young children.to better understand acquired immunity to respiratory-syncytial-virus infections, we analyzed data from a 10-year study of respiratory illness in normal children who were followed longitudinally from early infancy. immunity was measured in terms of failure to become infected or reduction in severity of clinical illness upon reinfection. outbreaks of infections occurred seven times over the 10-year-period. during epidemics the attack rate for first infection was 98 per cent. the rate for second i ...1979763253
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