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respiratory syncytial virus: a report of a 5-year study at a children's hospital.a study over a 5-year period (1979-1983) of rsv infections in children in sydney, australia is reported. in common with findings made elsewhere in the world, annual epidemics of rsv infection commencing in autumn and lasting 4-6 months, with peak activity in mid-winter, were observed in 1979, 1980, and 1983. however, in 1981 and 1982 virus activity was first detected in midsummer, peaked in autumn, and was present throughout most months of the year. the alteration in virus activity in 1981 and 1 ...19863746259
subgrouping of respiratory syncytial virus strains from australia and papua new guinea by biological and antigenic characteristics.strains of respiratory syncytial virus from 3 major areas of australia and papua new guinea (png) were analyzed for variations in their antigenic and biological properties and in the molecular weights of their major structural proteins. seventy-eight strains from infants and young children with lri were collected from 1981-1984. the rsv season in the australian cities lasted from april through september, with major peaks in july of each year, while the rsv season in tropical png was year-round, ...19948002781
clinical severity of respiratory syncytial virus group a and b infection in sydney, australia.respiratory syncytial virus (rsv) has two major antigenic groups, a and b. there is disagreement as to whether or not there is a difference in the clinical severity of disease caused by the two rsv groups. this 3-year prospective study of infants and children with rsv-positive bronchiolitis examines the relative virulence of rsv groups a and b and assesses the role that breast-feeding may have in modifying the clinical severity of infection. clinical severity was graded i (ventilated, severe), i ...19938284117
rate of seasonal spread of respiratory syncytial virus in a pediatric hospital.the rate of nosocomial respiratory syncytial virus (rsv) infection was measured in a large pediatric hospital using an incidence density method. the at-risk days for nosocomial rsv were summed during a defined winter period in which there were 54 admissions with community-acquired rsv infection giving a rate of 2.9 cases per 1,000 at-risk days (95% confidence interval, 0.3-5.4 per 1,000).19979397377
the association of respiratory viruses, temperature, and other climatic parameters with the incidence of invasive pneumococcal disease in sydney, australia.increases in incidence of invasive pneumococcal disease (ipd) during the colder months of the year in temperate regions are well recognized, but few detailed studies of possible interactions are available. we examined the relationship between virus activity, climatic parameters, and ipd during a winter in which there were separate peak incidences of influenza and respiratory syncytial virus (rsv) infection.200616355331
influenza related hospitalisations in sydney, new south wales, australia.routine influenza vaccination for children aged 6-23 months has recently been recommended in the united states. accurate assessment of influenza related burden of illness in children could support similar recommendations in other settings. however, routinely available data underestimate the role of influenza in causing hospitalisation, and indirect estimation methods face difficulties controlling for the concurrent circulation of respiratory syncytial virus (rsv). recent studies from hong kong a ...200616371373
respiratory syncytial virus infection and recurrent wheeze/asthma in children under five years: an epidemiological survey.to determine the rates of respiratory syncytial virus (rsv) infection in children under 5 years of age with recurrent wheeze or asthma and compare their clinical presentation, course and outcome with asthmatic children of the same age who did not have rsv.200717207052
influenza-related disease: the cost to the australian healthcare system.the disease burden attributable to influenza is difficult to determine, as influenza infections are rarely virologically confirmed or recorded. estimating the influenza-related disease burden is a prerequisite to estimate the costs. age-specific regression models were used to estimate the number of excess hospitalisations attributable to influenza from influenza and respiratory syncytial virus surveillance data. the number of general practitioner consultations for influenza/influenza-like illnes ...200818940222
otitis media: viruses, bacteria, biofilms and vaccines.otitis media typically presents as either acute otitis media (aom), with symptoms including fever, otalgia, otorrhoea or irritability and short duration; or as otitis media with effusion (ome), which is often asymptomatic and characterised by accumulation of fluid in the middle ear. diagnostic certainty of otitis media is challenging, given the young age of patients and variability of symptoms. otitis media predominantly occurs as coincident to viral upper respiratory tract infections and/or bac ...200919883356
evaluation of alternative respiratory syndromes for specific syndromic surveillance of influenza and respiratory syncytial virus: a time series analysis.syndromic surveillance is increasingly being evaluated for its potential for early warning of increased disease activity in the population. however, interpretation is hampered by the difficulty of attributing a causative pathogen. we described the temporal relationship between laboratory counts of influenza and respiratory syncytial virus (rsv) detection and alternative groupings of emergency department (ed) respiratory diagnoses.200919943970
Respiratory syncytial virus--the unrecognised cause of health and economic burden among young children in Australia.Respiratory syncytial virus (RSV) presents very similar to influenza and is the principle cause of bronchiolitis in infants and young children worldwide. Yet, there is no systematic monitoring of RSV activity in Australia. This study uses existing published data sources to estimate incidence, hospitalisation rates, and associated costs of RSV among young children in Australia. Published reports from the Laboratory Virology and Serology Reporting Scheme, a passive voluntary surveillance system, a ...201122010512
the burden of pneumonia in children: an australian perspective.the burden of pneumonia in australian children is significant with an incidence of 5-8 per 1000 person-years. pneumonia is a major cause of hospital admission in children less than 5 years of age. indigenous children are at particular risk with a 10-20-fold higher risk of hospitalisation compared to non-indigenous children. they also have longer admissions and are more likely to have multiple admissions with pneumonia. there are limited data on pathogen-specific causes of pneumonia, however stre ...200515911454
pilot testing standardized surveillance: hospital infection standardised surveillance (hiss). on behalf of the hiss reference group.in australia the time-consuming nature of double handling of surveillance data has meant that surveillance methodology rarely included prospective monitoring of patients at risk for the acquisition of a nosocomial infection. to streamline surveillance activities, infection control professionals favored the collection of case data either from the ward or pathology laboratories. by default, this method introduced a variety of definitions resulting in inconsistencies across health care facilities a ...200011114609
respiratory syncytial virus in children's hospitals. 19911683996
pandemic clinical case definitions are non-specific: multiple respiratory viruses circulating in the early phases of the 2009 influenza pandemic in new south wales, australia.during the early phases of the 2009 pandemic, subjects with influenza-like illness only had laboratory testing specific for the new a(h1n1)pdm09 virus.201424942807
relationship between the population incidence of pertussis in children in new south wales, australia and emergency department visits with cough: a time series analysis.little is known about the potential of syndromic surveillance to provide early warning of pertussis outbreaks. we conducted a time series analysis to assess whether an emergency department (ed) cough syndrome would respond to changes in the incidence of pertussis in children aged under 10 years in new south wales (nsw), australia, and to evaluate the timing of any association. a further aim was to assess the lag between the onset of pertussis symptoms and case notification in the infectious dise ...201323537222
relationship between the population incidence of febrile convulsions in young children in sydney, australia and seasonal epidemics of influenza and respiratory syncytial virus, 2003-2010: a time series analysis.in 2010, intense focus was brought to bear on febrile convulsions in australian children particularly in relation to influenza vaccination. febrile convulsions are relatively common in infants and can lead to hospital admission and severe outcomes. we aimed to examine the relationships between the population incidence of febrile convulsions and influenza and respiratory syncytial virus (rsv) seasonal epidemics in children less than six years of age in sydney australia using routinely collected s ...201122029484
high burden of rsv hospitalization in very young children: a data linkage study.linked administrative population data were used to estimate the burden of childhood respiratory syncytial virus (rsv) hospitalization in an australian cohort aged <5 years. rsv-coded hospitalizations data were extracted for all children aged <5 years born in new south wales (nsw), australia between 2001 and 2010. incidence was calculated as the total number of new episodes of rsv hospitalization divided by the child-years at risk. mean cost per episode of rsv hospitalization was estimated using ...201626626237
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