| emergence of a virulent clone of neisseria meningitidis serotype 2a that is associated with meningococcal group c disease in canada. | multilocus enzyme electrophoresis was used to characterize 378 isolates of neisseria meningitidis serogroup c recovered during a period of an increase in group c meningococcal disease in canada. thirty-four enzyme electrophoretic types were found among the isolates, which were predominantly (96.0%) serotype 2a. one clone (et 15), characterized by a rarely occurring allele for the enzyme fumarase, was responsible for a focal outbreak in ontario followed by the spread of group c disease across the ... | 1991 | 1774254 |
| serotypes of neisseria meningitidis associated with an increased incidence of meningitis cases in the hamilton area, ontario, during 1978 and 1979. | the distribution of serotypes among strains of neisseria meningitidis responsible for a marked increase of meningitis cases in the hamilton area, ontario, in 1978 and 1979 was determined. twenty-six serogroup b and two serogroup w135 strains isolated from cerebrospinal fluid, blood, and skin of 28 patients were serotyped by agar gel double diffusion. twenty-one (81%) of the group b strains were serotype 2b as judged by the formation of characteristic serotype precipitin bands with the specific a ... | 1983 | 6403211 |
| meningococcal infections in the hamilton area during 1978. | during 1978 there was a marked increase in the number of patients with meningococcal infection in the hamilton area. of 21 patients admitted to st. joseph's hospital, hamilton, two thirds were under 5 years of age. four patients died. all the isolates were sulfonamide-sensitive strains of serogroup b neisseria meningitidis. although no infections developed in contacts, several errors were made in the management of the hospital and household contacts of the infected patients: chemoprophylaxis was ... | 1980 | 6768439 |
| case report. neisseria meningitidis serogroup a in ontario. | | 1997 | 9376821 |
| management of a cluster of cases of invasive group c neisseria meningitidis infections in the hamilton-wentworth region--ontario. | | 1998 | 9704541 |
| neisseria meningitidis with decreased susceptibility to penicillin in ontario, canada 1997-2000. | | 2001 | 11381628 |
| characterization of neisseria meningitidis strains isolated from invasive meningococcal disease cases in canada in 2001. | with the recent introduction of polysaccharide-protein conjugated vaccines for the control of serogroup c meningococcal disease and the emergence of different variants of serogroup c meningococci, it is likely the epidemiology of meningococcal disease in many countries may be affected. we have therefore analysed and reported the characteristics of neisseria meningitidis strains collected in 2001 from the canadian surveillance program on invasive meningococcal disease. only strains collected from ... | 2003 | 14663497 |
| immunochemical studies and genetic background of two neisseria meningitidis isolates expressing unusual capsule polysaccharide antigens with specificities of both serogroup y and w135. | we described 2 unusual neisseria meningitidis strains isolated from epidemiologically unrelated invasive meningococcal disease cases in ontario, canada. both isolates have features typical of serogroup y n. meningitidis: are of serotype 2c, are of the multi-locus sequence types typical of the serogroup y strains in canada, and are genotyped as serogroup y based on a previously described pcr-elisa method that detects the serogroup-y-specific siad gene. however, both strains were poly-agglutinable ... | 2008 | 18388994 |
| rapid identification of herd effects with the introduction of serogroup c meningococcal conjugate vaccine in ontario, canada, 2000-2006. | in 2001, canada's national advisory committee on immunization endorsed a meningococcal serogroup c conjugate vaccine, which appears to provide durable serogroup-specific immunity while reducing nasopharyngeal carriage. with reference to direct and indirect effects on case occurrence, we sought to evaluate recent trends in the incidence of invasive meningococcal disease (imd) in ontario. analyses included all imd cases reported between 2000 and 2006 to the ontario central public health laboratory ... | 2009 | 19186206 |
| epidemiology of invasive meningococcal disease with decreased susceptibility to penicillin in ontario, canada, 2000 to 2006. | neisseria meningitidis has been relatively slow to acquire resistance to penicillin. we previously reported an increase in the incidence of invasive meningococcal disease (imd) strains with decreased susceptibility to penicillin (dsp) in ontario. our objectives were to evaluate trends in imd with dsp, to identify case-level predictors of imd with dsp, and to evaluate the relationship among dsp, bacterial phenotype, and the likelihood of a fatal outcome. all imd isolates received in ontario betwe ... | 2010 | 20086160 |
| epidemiology of serogroup c and y invasive meningococcal disease (imd) in ontario, 2000-2013: vaccine program impact assessment. | a publicly-funded meningococcal serogroup c conjugate vaccine (mccv) program was introduced in ontario, in 2004/2005 for 1-year-old children as well as adolescents (approximately 12 years old). in 2009, quadrivalent meningococcal conjugate vaccine (mcv4) replaced mccv for grade seven students. our objective was to determine meningococcal vaccine program impact on reported cases of serogroup c and y invasive meningococcal disease (imd) at the population level in ontario, canada. | 2015 | 26299749 |
| economic evaluation of meningococcal serogroup b childhood vaccination in ontario, canada. | invasive neisseria meningitidis serogroup b (menb) disease is a low incidence but severe infection (mean annual incidence 0.19/100,000/year, case fatality 11%, major long-term sequelae 10%) in ontario, canada. this study assesses the cost-effectiveness of a novel menb vaccine from the ontario healthcare payer perspective. | 2014 | 25131732 |
| genetic and antigenic characterization of invasive endemic serogroup b neisseria meningitidis from ontario, canada, in 2001-2010. | this study examined the antigenic and genetic diversity of serogroup b neisseria meningitidis (menb) recovered from invasive meningococcal disease (imd) cases in ontario, canada, over the period 2001-2010 during which no menb outbreaks had occurred. menb was found to be responsible for 39 % of all imd cases, with the remaining cases caused mainly by serogroups y (28 %), c (23.5 %) and w135 (8 %). one hundred and ninety-three individual menb case isolates were collected and characterized. of the ... | 2013 | 23038803 |