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cefotaxime-resistant enterobacteriaceae isolates from a hospital in warsaw, poland: identification of a new ctx-m-3 cefotaxime-hydrolyzing beta-lactamase that is closely related to the ctx-m-1/men-1 enzyme.a group of cefotaxime-resistant citrobacter freundii and escherichia coli isolates were collected by a clinical laboratory in a hospital in warsaw, poland, in july 1996. detailed analysis has shown that all of these produced a beta-lactamase (pi, 8.4) belonging to the ctx-m family, one of the minor extended-spectrum beta-lactamase families with a strong cefotaxime-hydrolyzing activity. sequencing has revealed that c. freundii isolates produced a new ctx-m-3 enzyme which is very closely related t ...19989559791
countrywide spread of ctx-m-3 extended-spectrum beta-lactamase-producing microorganisms of the family enterobacteriaceae in poland.eighty-four clinical isolates of the family enterobacteriaceae, recovered from 1998 to 2000 in 15 hospitals in 10 polish cities, were analyzed. all the isolates produced beta-lactamases with pis of 8.4 and 5.4, and the pi 8.4 enzymes were demonstrated to hydrolyze cefotaxime but not ceftazidime in the in vitro bioassay. pcr analysis and dna sequencing have revealed that in all cases the pi 8.4 beta-lactamase was probably the ctx-m-3 extended-spectrum beta-lactamase (esbl) variant, which was orig ...200211751126
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