| an association between hiv-1 subtypes and mode of transmission in cape town, south africa. | to determine hiv-1 env and gag subtypes in male homosexual and heterosexual populations in cape town, south africa. | 1997 | 9110079 |
| the south african hiv epidemic, reflected by nine provincial epidemics, 1990-1996. | to determine by serological examination the annual point prevalence rates of infection with the human immunodeficiency virus (hiv) in representative samples of subjects in the nine provinces of south africa, 1990-1996. | 1998 | 9807188 |
| transmission of a multidrug-resistant mycobacterium tuberculosis strain resembling "strain w" among noninstitutionalized, human immunodeficiency virus-seronegative patients. | since 1990, several outbreaks of multidrug-resistant tuberculosis (mdr-tb) have been described among institutionalized patients infected with human immunodeficiency virus (hiv). we describe a community mdr-tb outbreak among hiv-seronegative patients in cape town, south africa. isolates were characterized by restriction fragment length polymorphism (rflp) analysis and dot-blot hybridization analysis of mutations conferring resistance for isoniazid, rifampin, streptomycin, and ethambutol. all isol ... | 1999 | 10515823 |
| human immunodeficiency virus infection and genital ulcer disease in south africa: the herpetic connection. | while genital ulcers are a risk factor in hiv infection, the association of specific agents of genital ulcer disease (gud) with hiv infection may vary. | 2000 | 10654864 |
| human immunodeficiency virus-associated pure motor lumbosacral polyradiculopathy. | neuromuscular disease is a common manifestation of human immunodeficiency virus infection and acquired immunodeficiency syndrome, but isolated and severe pathology confined to the motor roots or anterior horn cells are not a recognized clinical entity. | 2000 | 10891986 |
| porphyria cutanea tarda: the etiological importance of mutations in the hfe gene and viral infection is population-dependent. | a number of factors, including increased iron stores and alcohol consumption, are known to be associated with the development of porphyria cutanea tarda (pct) in susceptible individuals. recent reports have described a significant association between inheritance of the c282y and h63d mutations in the hfe gene, associated with genetic hemochromatosis (gh) and pct. a strong association between hepatitis c virus infection and pct has also been demonstrated, while case reports record a link between ... | 2002 | 12699243 |
| the case for integrating tuberculosis and hiv treatment services in south africa. | integration of human immunodeficiency virus (hiv) and tuberculosis (tb) services is critical to effectively addressing both epidemics in south africa. examples of the specific need to integrate tb and hiv services are presented from a community in cape town, south africa, with high burdens of hiv infection and tb and from an antiretroviral therapy (art) program in a peri-urban township. tb and hiv service integration is needed in 3 specific scenarios presented in this article: for the public hea ... | 2007 | 18181700 |
| high level of discordant igra results in hiv-infected adults and children. | tygerberg district, western cape province, south africa. | 2008 | 18371268 |
| phylogenetic diversity and low level antiretroviral resistance mutations in hiv type 1 treatment-naive patients from cape town, south africa. | we analyzed the hiv-1 pol gene from patients in cape town to determine the genetic diversity of hiv-1 in the region and to assess the baseline hiv-1 resistance level of treatment-naive patients. plasma was collected prior to the national antiretroviral therapy (art) program. rna was extracted, followed by rt-pcr and automated dna sequencing of the viral protease (pr) and reverse transcriptase (rt) coding region. genotyping was done through phylogenetic analysis. the sequences were inspected for ... | 2008 | 18593350 |
| outcomes of human immunodeficiency virus-infected and -exposed children undergoing surgery--a prospective study. | human immunodeficiency virus (hiv)/acquired immune deficiency syndrome (aids) is a worldwide pandemic. mother-to-child transmission programs should theoretically minimize vertical transfer of the virus, but with variable effectiveness of implementation a significant number of children become infected and may present for emergency, diagnostic, and elective surgery. the aim of this study was to prospectively document the clinical presentation, the spectrum of pathology, and surgical outcomes of pa ... | 2009 | 19361626 |
| molecular characterization of non-subtype c and recombinant hiv-1 viruses from cape town, south africa. | hiv was first diagnosed within south africa in 1982. homosexual transmission of hiv-1 dominated the epidemic within the country in the early stages of the 1980s. currently heterosexual transmission of hiv-1 is responsible for the majority of hiv cases in south africa with subtype c hiv-1 being responsible for an estimated 95% of infections. only a few papers have been published on non-subtype c hiv-1 detection within south africa. this study characterized subgenomic and near full-length sequence ... | 2009 | 19446657 |
| emergence and diversity of different hiv-1 subtypes in south africa, 2000-2001. | hiv-1 is a major health problem in south africa with an average prevalence rate of 29.1% in pregnant women and between 4.9 and 6.1 million people infected. using env gp120 v3 serotyping and genotyping techniques 410 patient samples were investigated. most of the samples were obtained from different clinics in the greater cape town area of the western cape province in south africa. these included an academic hospital, state and private clinics, an informal settlement, sex worker cohorts, and the ... | 2009 | 19774685 |
| the changing natural history of tuberculosis and hiv coinfection in an urban area of hyperendemicity. | tuberculosis (tb) has proven to be difficult to control in regions with a high prevalence of human immunodeficiency virus (hiv) infection. we previously described high prevalence of hiv infection among adults (23%) and rapidly escalating tb notification rates in a peri-urban township, site-m in cape town, south africa. the combination of delineated boundaries, a well-characterized population, centralized tb record keeping, and high levels of hiv testing make this population uniquely suited for t ... | 2010 | 20397950 |
| renal manifestations in children co-infected with hiv and disseminated tuberculosis. | many children in cape town are co-infected with human immunodeficiency virus (hiv) and tuberculosis (tb). granulomatous tb interstitial nephritis is a recognized entity. our objective was to establish if tb plays a role in renal disease in hiv-infected children. we identified children co-infected with tb and hiv from our database and reviewed their biopsies and clinical notes. since 2002, 12 renal biopsies or postmortem examinations were performed on hiv-infected children at our institution. the ... | 2010 | 20422226 |
| maternal hiv infection and antibody responses against vaccine-preventable diseases in uninfected infants. | altered immune responses might contribute to the high morbidity and mortality observed in human immunodeficiency virus (hiv)-exposed uninfected infants. | 2011 | 21304083 |
| sexual health, hiv risk, and retention in an adolescent hiv-prevention trial preparatory cohort. | although adolescents are at high risk for human immunodeficiency virus (hiv) infection, they have not been, included in hiv vaccine trials. | 2011 | 21700155 |
| Early antiretroviral treatment reduces risk of bacille Calmette-Guérin immune reconstitution adenitis. | Two centres in Soweto and Cape Town, South Africa. | 2011 | 21943845 |