| altered cellular but not humoral reactions in children with complicated enterovirus 71 infections in taiwan. | enterovirus 71 (ev 71) infections have high neurovirulence and fatality. immune responses were assessed in 78 patients with ev 71 infection. ev 71 meningoencephalitis occurred more frequently in younger children and in boys. c-reactive protein levels were not elevated, although total leukocyte counts were increased in these patients. the cd40-ligand expression on t cells significantly decreased in children with meningoencephalitis (p=.041). polymorphism of the cytotoxic t lymphocyte antigen-4 (c ... | 2001 | 11237800 |
| inferring nonneutral evolution from contrasting patterns of polymorphisms and divergences in different protein coding regions of enterovirus 71 circulating in taiwan during 1998-2003. | enterovirus (ev) 71 is one of the common causative agents for hand, foot, and, mouth disease (hfmd). in recent years, the virus caused several outbreaks with high numbers of deaths and severe neurological complications. despite the importance of these epidemics, several aspects of the evolutionary and epidemiological dynamics, including viral nucleotide variations within and between different outbreaks, rates of change in immune-related structural regions vs. non-structural regions, and forces d ... | 2010 | 20868512 |
| enterovirus 71: epidemiology, pathogenesis and management. | enterovirus 71 (ev71) has emerged as a major cause of neurological threat in the world following the eradication of poliovirus. most ev71 infections commonly result in hand-foot-mouth disease or herpangina, and some cases are associated with brainstem encephalitis and acute flaccid paralysis. mortality was high in ev71 brainstem encephalitis complicated with pulmonary edema, particularly in children below 5 years of age. destruction of vasomotor in the brainstem by ev71 produces autonomic nervou ... | 2009 | 19681701 |