| status of the response of plasmodium falciparum to chloroquine and mefloquine in iran. | malaria is still the most important parasitic disease in the southeastern part of iran. the in vivo and in vitro studies of the response of plasmodium falciparum to chloroquine in sistan-baluchestan and hormozgan provinces (1985-1987) have shown resistance in iran-shahr and bandar abbas areas. however the parasite was sensitive in minab area. from 38 chloroquine-resistant p. falciparum (crpf) cases, found in the studied malarious areas, 13 cases were in afghan immigrants, 3 in pakistani and 3 in ... | 1989 | 2699684 |
| preliminary study of the response of plasmodium falciparum to chloroquine in sistan and baluchestan province of iran. | | 1985 | 3909559 |
| assessment of the response in vivo and in vitro of plasmodium falciparum to sulphadoxine-pyrimethamine in the malarious areas of iran. | studies of drug resistance of plasmodium falciparum cases from se iran were carried out in vivo and in vitro during 1990-91. in a study of 26 chloroquine-resistant infections, using amodiaquine (25 mg kg-1 over 3 days), followed by two-thirds of the standard dose of sulphadoxine-pyrimethamine, six cases were resistant at the ri(3) and rii(3) levels. an additional study testing the standard dose of sulphadoxine-pyrimethamine in 43 chloroquine-resistant cases revealed five (11.6%) resistant at the ... | 1993 | 8345544 |
| role of anopheles culicifacies s.l. and an. pulcherrimus in malaria transmission in ghassreghand (baluchistan), iran. | a 2-site immunoradiometric assay (irma) was performed on the head and thorax of anopheles culicifacies s.l. and an. pulcherrimus females, the 2 most common anopheline species in the district of ghassreghand (baluchistan, iran), collected during the 2 peak malaria transmission seasons (may and september-october 1991). positive irma results revealed the 2 species as potential vectors of malaria in this highly endemic district. this finding serves as the first report on natural infection of an. pul ... | 1993 | 8468570 |
| high prevalence of double plasmodium falciparum dhfr mutations at codons 108 and 59 in the sistan-baluchistan province, iran. | | 2003 | 12751044 |
| multiple genotypes of the merozoite surface proteins 1 and 2 in plasmodium falciparum infections in a hypoendemic area in iran. | in iran, malaria transmission mainly occurs in south-eastern regions through both plasmodium falciparum and p. vivax. the genetic diversity of p. falciparum isolates was analysed in 108 patients attending the regional hospital in chabahar district, using the molecular markers msp1 and msp2. multiple genotypes were detected in 87% of patients and the mean numbers of msp1 and msp2 genotypes were 2.51 (95% ci: 2.29-2.73) and 2.61 (95% ci: 2.39-2.83) respectively. various allelic types of msp1 and m ... | 2005 | 16185241 |
| monitoring of the therapeutic efficacy of chloroquine for the treatment of uncomplicated, plasmodium falciparum malaria in iran. | between 2002 and 2004, the standardized 28-day protocol recently developed by the world health organization was used to explore the efficacy of chloroquine, in the treatment of uncomplicated, plasmodium falciparum malaria, in five sentinel sites in southern iran. all but 14 of the 158 patients enrolled (128, 28 and two from the provinces of sistan-baluchestan, hormozgan and kerman, respectively) were successfully followed-up. the overall frequency of treatment failure by day 28 was 78.5%, with 1 ... | 2006 | 16417708 |
| genotypes and in vivo resistance of plasmodium falciparum isolates in an endemic region of iran. | mutations in the dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) genes of plasmodium falciparum have been correlated with and used to detect antifolate treatment failure, such as sulfadoxine-pyrimethamine (sp), in regions endemic for malaria. to determine the association between molecular markers of sp resistance and in vivo drug resistance, a quick and simple technique that detects single nucleotide polymorphisms in the dhfr and dhps genes, using pcr-elisa and sequence-specif ... | 2007 | 17024359 |
| high rate of detection of mixed infections of plasmodium vivax and plasmodium falciparum in south-east of iran, using nested pcr. | sistan and baluchestan province, south-east of iran, has been reported as an endemic area of malaria [sadrizadeh b. malaria in the world, in the eastern mediterranean region and in iran: review article. who/emro report 2001: 1-13.]. the main objective of this research was to perform rapid and correct diagnoses of malaria infection. blood specimens were collected from 140 suspected volunteers. the giemsa-stained slides examination and nested pcr for amplification of the plasmodium small subunit r ... | 2007 | 17257891 |
| prevalence of mutations associated with antimalarial drugs in plasmodium falciparum isolates prior to the introduction of sulphadoxine-pyrimethamine as first-line treatment in iran. | this work was carried out to assess the patterns and prevalence of resistance to chloroquine (cq) and sulphadoxine-pyrimethamine (sp) in iran. | 2007 | 17999755 |
| patterns of co-association of c-reactive protein and nitric oxide in malaria in endemic areas of iran. | in addition to numerous immune factors, c-reactive protein (crp) and nitric oxide (no) are believed to be molecules of malaria immunopathology. the objective of this study was to detect crp and no inductions by agglutination latex test and griess microassay respectively in both control and malaria groups from endemic areas of iran, including southeastern (se) (sistan & balouchestan, hormozgan, kerman) and northwestern (nw) provinces (ardabil). the results indicated that crp and no are produced i ... | 2008 | 18368235 |
| mutation in pfmdr1 gene in chloroquine-resistant plasmodium falciparum isolates, southeast iran. | the main objective of the present study was to detect point mutations at positions 86, 184, 1034, 1042, and 1246 of the plasmodium falciparum multidrug resistance gene (pfmdr1) in blood samples collected from malaria patients in chabahar, a harbor city located in southeast iran. | 2008 | 18926753 |
| a preliminary study of genetic diversity of msp-1 types in plasmodium falciparum in southern province of sistan baluchistan of iran. | plasmodiumfalciparum merozoite surface protein-1 (msp-1) shows extensive antigenic diversity. this is due to the presence of seven variable blocks, five semi-conserved and also five conserved blocks. the variable blocks in the msp-1 gene are principally dimorphic, displaying either k1 or mad20 type; except for the block 2 region which is represented by three alleles, an ro33 type in addition to the other two. allelic diversity is reported to be generated by intra-genic recombination between the ... | 2007 | 19069502 |
| detection of asymptomatic malaria infection among the afghani immigrant population in iranshahr district of southeastern iran. | asymptomatic malaria infection is often associated with subpatent level of parasitaemia and normal clinical examination. such infection becomes a greater cause for concern when involved in blood transfusion and vector transmission. this study was performed to monitor the situation of asymptomatic malaria among the afghani immigrants and native residents in iranshahr district, a malaria endemic area in southeastern iran, by performing conventional light microscopy. out of 446 samples collected fr ... | 2011 | 21312079 |