| pyrimethamine susceptibility status of p. falciparum in karbi-anglong district of assam and adilabad district of andhra pradesh. | | 1980 | 7014699 |
| present perspectives of malaria transmission in boko area of assam. | a longitudinal study on malaria transmission was conducted from january 1984 to december 1988 in three villages in boko phc of assam, where indoor residual ddt spray was withdrawn during the period of study. anopheline fauna comprising of 19 species was identified and their seasonal density estimated. anopheles philippinensis was the predominant species followed by an. minimus. the principal role of an. minimus in the transmission of malaria and predilection for indoor resting in this area was c ... | 1993 | 8014435 |
| response of plasmodium falciparum to chloroquine in digboi area of assam, india. | | 1996 | 8973024 |
| epidemiological importance of younger age group during malaria epidemic in phc tamulpur, assam. | an investigation of a malaria epidemic was carried out in tamulpur primary health centre, district nalbari, assam during april 1995. the analysis revealed that children between 3 and 12 years of age who were treated and who recovered clinically from fever during the epidemic were instrumental in the progression of the epidemic by acting as plasmodium falciparum gametocyte reservoirs. special efforts are required for treatment of children below 12 years during an epidemic. | 1998 | 10810560 |
| anopheles minimus: its bionomics and role in the transmission of malaria in assam, india. | indoor, day-resting collections of anopheles minimus mosquitos from human dwellings in the study area in assam, india, indicated that these insects were prevalent throughout the year and that their maximum abundance occurred from march to august. a. minimus was identified as a vector of malaria, and sporozoite infections were recorded every month of the year, with the highest rating occurring in october. the mosquito was highly anthropophilic and fed on human hosts (indoor) all through the night ... | 1996 | 8653817 |
| susceptibility of plasmodium falciparum to chloroquine in tea garden tribes of assam, india. | p. falciparum was the predominant parasite ( > 80%) species in malaria ridden tea estates of assam. a simplified 3 day in vivo test to determine chloroquine sensitivity in tea garden tribes revealed that the majority of the cases (85%) were s/ri, 7% were ri, and 3% were rii and 5% were riii, respectively. early case detection and treatment were deemed necessary to reduce morbidity and mortality due to p. falciparum in these tea estates. | 1995 | 8629050 |
| chloroquine versus amodiaquine in the treatment of plasmodium falciparum malaria in northeast india. | amodiaquine is being used in india for presumptive treatment as an alternative to chloroquine in areas with chloroquine resistant p. falciparum. keeping in view the toxicity of amodiaquine, studies have been undertaken to evaluate the advantage of the drug over chloroquine in the treatment of p. falciparum malaria. in vivo drug resistance studies were carried out in the states of assam and meghalaya in india. a total of 388 subjects have been studied to compare the efficacy of chloroquine and am ... | 1995 | 8543350 |
| response to 600 mg amodiaquine base with 45 mg primaquine as presumptive treatment in chloroquine resistant plasmodium falciparum infection in assam. | | 1980 | 7014425 |
| malaria incidence in leprosy patients under dapsone therapy in karbi-anglong district, assam. | | 1982 | 6759567 |
| chloroquine resistant p. falciparum malaria in assam and meghalaya. | | 1984 | 6399261 |
| incrimination of anopheles dirus as a vector of malaria in dibrugarh district, assam. | anopheles nigerrimus, a. vagus, a. dirus, a. karwari and a. kochi were the most abundant species among 12 anopheline species collected during the course of entomological studies carried out from july to september, 1988 in an area endemic for malaria under tengakhat phc of dibrugarh district, assam. sporozoites were detected in the salivary glands of one specimen of a. dirus, peyton & harrison (a. balabacensis) which constituted about 18.11 per cent of the total anopheline collection. | 1989 | 2699591 |
| efficacy of sulfalene and pyrimethamine combination drugs alone and with quinine in treatment of p. falciparum cases in chloroquine resistant areas of north east india. | studies were carried out in some areas of assam, nagaland, west bengal and mizoram where chloroquine resistant strains of plasmodium falciparum were present during 1983 and 1984, to see the efficacy of treatment of p. falciparum cases with slp alone or with quinine sulphate. the findings have indicated that slp in the dosage of sulfalene (1000 mg) + pyrimethamine (50 mg) is suitable for treatment of p. falciparum cases not responding to chloroquine therapy in n.e. india. treatment with sulfalene ... | 1990 | 2098422 |
| studies on genetic polymorphism in relation to malaria in tea gardens of dibrugarh district, assam. | | 1990 | 2093007 |
| efficacy of a low dose oral quinine therapy in plasmodium falciparum cases of assam, meghalaya and arunachal pradesh in india. | a low dose oral quinine schedule with 1050 mg in two divided doses daily for five days was tried for treatment of plasmodium falciparum cases in assam, meghalaya and arunachal pradesh, in areas where resistance to chloroquine was confirmed. the drug schedule was found effective in 76.92 per cent cases. the treatment was also found effective in 45.55 per cent of the known chloroquine resistant p. falciparum cases. the drug in this low dose was well tolerated and clinical response was quick. | 1991 | 1842806 |
| a longitudinal study to monitor chloroquine-resistant p. falciparum malaria in bokajan and manja phc areas of karbi anglong district, assam. | in-vivo as well as in-vitro studies were carried out at regular intervals from 1979 to 1988 to monitor chloroquine resistance in p. falciparum in bokajan and manja phc of karbi anglong district, assam. the results showed no significant change in resistance status in the area. intensified antivector measures, withdrawal of chloroquine pressure and prompt detection and treatment of p. falciparum cases with alternative drugs helped bring down the higher grades of resistant parasites by 1984, which ... | 1992 | 1286733 |
| chloroquine resistance in p. falciparum in assam state. | | 1979 | 398331 |
| plasmodium falciparum isolates in india exhibit a progressive increase in mutations associated with sulfadoxine-pyrimethamine resistance. | the combination of sulfadoxine-pyrimethamine (sp) is used as a second line of therapy for the treatment of uncomplicated chloroquine-resistant plasmodium falciparum malaria. resistance to sp arises due to certain point mutations in the genes for the dihydrofolate reductase (dhfr) and dihydropteroate synthetase (dhps) enzymes of the parasite. we have analyzed these mutations in 312 field isolates of p. falciparum collected from different parts of india to assess the effects of drug pressure. the ... | 2004 | 14982779 |
| therapeutic efficacies of antimalarial drugs in the treatment of uncomplicated, plasmodium falciparum malaria in assam, north-eastern india. | in the indian state of assam, the current therapeutic efficacies of the drugs commonly used in the area for the treatment of uncomplicated, plasmodium falciparum malaria were investigated. as is routine in this area, subjects found positive for p. falciparum malaria were initially treated with chloroquine (cq). they were given sulfadoxine-pyrimethamine (sp) if this treatment failed, and subsequently quinine if the sp failed. the protocol of the world health organization's extended in-vivo test w ... | 2003 | 14754490 |
| multi-drug resistant plasmodium falciparum malaria in assam, india: timing of recurrence and anti-malarial drug concentrations in whole blood. | the susceptibility of 23 cases of plasmodium falciparum malaria from the sonapur primary health center in the kamrup district of assam, india to different antimalarials was investigated using the 28-day world health organization in vivo test. whole blood concentrations of chloroquine, sulfadoxine, and quinine were determined at different intervals and at the time of parasites recrudescence after completion of treatment with the respective drugs to confirm the status of drug sensitivity. a case o ... | 2003 | 14695096 |
| estimation of vectorial capacity of anopheles dirus (diptera: culicidae) in a forest-fringed village of assam (india). | to estimate the vectorial capacity of anopheles dirus, the main vector of forest malaria in the northeastern region of india, in order to gain an understanding of entomological factors related to malaria transmission in forest-fringe areas of assam, india, an isolated village in the tropical rain forest-fringed area in the district of dibrugarh, assam, under the influence of an. dirus alone was studied. data on various entomological variables required for computation of the vectorial capacity we ... | 2001 | 12653151 |
| malaria: radical treatment for falciparum malaria in chloroquine resistant strain areas. | a trend exists in areas hyperendemic for plasmodium falciparum (pf) malaria toward an increasing frequency and degree of resistance to chloroquine therapy. aside from intense pf transmission in the northeastern sector of india, there is constant population movement particularly across the international border with bangladesh. resistance is high and widespread in those areas. chloroquine resistance has also been observed in project areas, with some tendency toward increased resistance. the fi ... | 1998 | 12321868 |
| an outbreak of plasmodium falciparum malaria due to anopheles minimus in central assam, india. | epidemiological investigations were conducted in nellie subcentre, phc jhargaon, under morigaon district (assam). the results of fever cases revealed 68 per cent slide positivity rate (spr) and 40 per cent slide falciparum rate (sfr). the pf proportion was > 87 per cent and remaining cases were p. vivax infections. an. minimus was incriminated as a malaria vector during the study period. the sporozoite rate was 3.08 per cent. the indoor man mosquito contact was 35 per bait/night as against 23 in ... | 2001 | 11963818 |
| epidemiological observations on malaria in some parts of darrang district, assam. | a study on malaria conducted in tribal villages of darrang district, assam during april 1994 to march 1995 revealed that the malaria incidence due to plasmodium falciparum was considerably high. slide positivity rate (spr) ranged between 2.3 to 45.67 per cent with transmission from may to october. p. falciparum was the dominant species (91.7 per cent) followed by p. vivax (7.25 per cent) and mixed infection (pv + pf = 1.05 per cent). malaria cases were recorded throughout the year in all the age ... | 2001 | 11963817 |
| malaria-attributable morbidity in assam, north-eastern india. | malaria is endemic in the indian state of assam and transmission of the causative parasites is perennial and persistent. the available data on malaria-related morbidity and mortality in the state for the years 1991-1999 have been reviewed. over this period, plasmodium falciparum was the predominant parasite, causing 58%-68% of the malaria cases; all other cases were attributed to p. vivax. all malaria-related deaths were attributed to p. falciparum infection, and the numbers of such deaths were ... | 2001 | 11784433 |
| epidemiology of malaria outbreak (april/may, 1999) in titabor primary health centre, district jorhat (assam). | an investigation was undertaken of a malaria outbreak in the primary health centre titabor, district jorhat, assam during may/june 1999. the fever rate in the community since march 1999, was 44.4 per cent with an average case load of 2.5 per family. the fever cases peaked in the third week of may. slide positive and slide falciparum rates in mass blood survey, in the study village were 16.1 and 14.5 per cent respectively with 90 per cent infection of plasmodium falciparum. males (spr 17.5%) suff ... | 2000 | 10935318 |
| seasonal prevalence of anopheles dirus and malaria transmission in a forest fringed village of assam, india. | seasonal abundance of anopheles dirus (s.l.) and malaria prevalence in an isolated forest fringed village was monitored at monthly intervals during august 1995 to july 1996. an. dirus was the only vector species detected during the study period. its density pattern showed distinct seasonality with the peak occurring in the month of july and very low number during cool dry months. positive correlation (r = 0.721) was found between the density of an. dirus and the amount of rainfall occurring two ... | 1997 | 9519567 |
| role of anopheles culicifacies during an outbreak of malaria in gorubandha p.h.c., assam. | entomological investigation during an outbreak of malaria in gorubandha phc in sonitpur district revealed unusually high density of anopheles culicifacies followed by an.minimus. parity rates of both the species were very high, 65% and 62.2% respectively. an. culicifacies was incriminated as malaria vector. sporozoite rate recorded was 0.63%. both the species were found susceptible to ddt. this substantiates the epidemiological observation which yielded 98% plasmodium falciparum malaria out of 3 ... | 1997 | 9465529 |
| polymerase chain reaction detection of human host preference and plasmodium parasite infections in field collected potential malaria vectors. | this study was carried out to determine the human host preference and presence of plasmodium parasite in field collected anopheles mosquitoes among four villages around a military cantonment located in malaria endemic sonitpur district of assam, india. encountered malaria vector mosquitoes were identified and tested for host preference and plasmodium presence using pcr method. human host preference was detected using simple pcr, whereas vectorial status for plasmodium parasite was confirmed usin ... | 2012 | 23265376 |
| morbidity and mortality due to malaria in tarajulie tea estate, assam, india. | beginning 1991, a sudden rise of malaria cases were recorded in tarajulie te (assam) coupled with mortality due to malaria. deaths were confirmed due to plasmodium falciparum (pf) infections and were recorded in all age groups excluding infants. malaria positives were recorded in all months of the year, however, there was a increased hospital attendance due to fever/malaria positives during may to september. during the years (1991-1993), the slide positive rate was as high as 33.04%, mostly bein ... | 1996 | 9185263 |
| effect of arteether alpha/beta on uncomplicated falciparum malaria cases in upper assam. | thirty patients of uncomplicated plasmodium falciparum malaria completed a clinical trial of arteether alpha/beta conducted in a malaria endemic tea garden of district dibrugarh, assam. arteether was given intramuscularly in once a day dose of 150 mg for three consecutive days. the cure rate was 100 per cent with mean fever and parasite clearance time of 42.4 +/- 17.5 and 37.6 +/- 13.6 h respectively. recrudescence/reinfection rate was 6.7 per cent. palpable spleens of twenty out of twenty one c ... | 1996 | 8979518 |
| assessment of therapeutic efficacy of chloroquine and sulphadoxine-pyrimethamine in uncomplicated falciparum malaria. | a standardised protocol has been developed by world health organization (cds/rbm/2002) to assess the efficacy of common antimalarials in the treatment of clinically manifested infection with uncomplicated p. falciparum malaria for areas with low to moderate transmission. the therapeutic efficacy protocol is based on clinical and parasitological responses of the patients and it has the purpose of determining the practical efficacy of the drug regimen in study areas with the ultimate objective of ... | 2003 | 15119078 |
| role of the prevalent anopheles species in the transmission of plasmodium falciparum and p. vivax in assam state, north-eastern india. | in north-eastern india, anopheles minimus, an. dirus and an. fluviatilis are considered the three major vectors of the parasites causing human malaria. the role in transmission of the other anopheles species present in this region is not, however, very clear. to examine the vectorial role of the more common anopheline mosquitoes, the heads and thoraces of 4126 female anopheles belonging to 16 species (collected using miniature light traps set in human dwellings in a foothill village in the jorha ... | 2004 | 15324463 |
| physiographic and entomologic risk factors of malaria in assam, india. | fever surveys were conducted in several districts of the indian state of assam to ascertain the prevalence of malaria in relation to vector abundance, entomologic inoculation rates (eirs), and geographic location of human settlements. anopheles minimus were incriminated, but their relative abundance and biting rates varied among districts, and no significant correlation was observed between these two indicators (r = 0.43, p = 0.34). plasmodium falciparum was the predominant parasite species exce ... | 2004 | 15516642 |
| the drug sensitivities of plasmodium falciparum in the sonitpur district, assam, india. | falciparum malaria is an ongoing problem in the foothills of northeast india. evaluation of the drug sensitivities of p. falciparum was carried out in four endemic villages of the sonitpur district of assam, involving 218 cases who were tested in vivo over 35 days. chloroquine resistance was detected at the ri level in 29 cases (13%) and rii level in 8 cases (4%). no riii chloroquine resistant cases were detected in the study. ri resistance was observed in the age groups 6-10 years, 11-14 years, ... | 2005 | 16124421 |
| malaria parasite burden and treatment seeking behavior in ethnic communities of assam, northeastern india. | the objectives of the study were to define the infectious reservoir of malaria with particular reference to transmission dynamics of plasmodium falciparum, and to ascertain the disease trends in view of the existing containment practices and treatment seeking behavior in malaria endemic communities of assam, india. | 2006 | 16442438 |
| potential of anopheles philippinensis-nivipes complex mosquitoes as malaria vector in north-east india. | anopheles philippinensis-nivipes complex mosquitoes, captured in outdoor human landing catches and light traps in human dwellings from four different sites in assam state and adjoining areas, were examined (n=1670) for the presence of circumsporozoite antigen (csa) through enzyme linked immunosorbent assays (elisa), using species specific capture monoclonal antibodies, of plasmodium falciparum and two plasmodium vivax polymorphs (pv 210 and vk 247). in elisa, 28 pools were found positive for csa ... | 2005 | 16459563 |
| prevalence of mutations associated with higher levels of sulfadoxine-pyrimethamine resistance in plasmodium falciparum isolates from car nicobar island and assam, india. | to assess sulfadoxine and pyrimethamine resistance (spr), we describe here the dihydropteroate synthetase (dhps) mutations among the plasmodium falciparum isolates in which dihydrofolate reductase (dhfr) mutations had recently been described by us (a. ahmed, m. k. das, v. dev, m. a. saifi, wajihullah, and y. d. sharma, antimicrob. agents chemother. 50:1546-1549, 2006). a majority of isolates from car nicobar island showed double dhps mutations, whereas a majority of isolates from uttar pradesh ( ... | 2006 | 16982787 |
| genetic structure of plasmodium falciparum field isolates in eastern and north-eastern india. | molecular techniques have facilitated the studies on genetic diversity of plasmodium species particularly from field isolates collected directly from patients. the msp-1 and msp-2 are highly polymorphic markers and the large allelic polymorphism has been reported in the block 2 of the msp-1 gene and the central repetitive domain (block3) of the msp-2 gene. families differing in nucleotide sequences and in number of repetitive sequences (length variation) were used for genotyping purposes. as lim ... | 2007 | 17517129 |
| temporal and spatial variation in msp1 clonal composition of plasmodium falciparum in districts of assam, northeast india. | polymorphism in msp1 gene generated by insertion/deletion of repeats causing repeat length polymorphisms is widely used as a marker for parasite genotyping. elucidating plasmodium falciparum clonal composition in relation to transmission intensity and other epidemiological factors in endemic areas is crucial to understanding the dynamics of host-parasite relationship and the development of immunity in malaria. we have examined here the allelic diversity of p. falciparum and attempted to understa ... | 2009 | 19454325 |
| emergence of drug resistance in india. | chloroquine resistance in plasmodium malaria is an emerging problem globally. in india resistance of plasmodium falciparum to choloroquine, the cheapest and the most used drug was first reported in the year 1973 from diphu of karbi-anglong district in assam state. systematic monitoring of drug resistance is being undertaken in the country from 1978 by the directorate of national vector borne disease control programme (nvbdcp) through its 13 pf monitoring teams. the findings of these drug resista ... | 2008 | 19552104 |
| wash resistance and residual efficacy of long-lasting polyester netting coated with alpha-cypermethrin (interceptor) against malaria-transmitting mosquitoes in assam, northeast india. | malaria is endemic in assam, northeast india, with low-to-moderate transmission of the causative parasites, mostly by anopheles minimus. plasmodium falciparum is the predominant parasite (>60%), with remaining cases being due to p. vivax. as an alternative intervention for malaria control, long-lasting insecticidal nets [interceptor coated with alpha-cypermethrin 10% suspension concentrate (sc), 0.667% w/w, 0.2g/m(2)] underwent field evaluation for laboratory wash resistance and residual efficac ... | 2010 | 19762058 |
| characteristics of genetic hitchhiking around dihydrofolate reductase gene associated with pyrimethamine resistance in plasmodium falciparum isolates from india. | sulfadoxine-pyrimethamine (sp) resistance in plasmodium falciparum has been widespread across continents, causing the major hurdle of controlling malaria. resistance is encoded mainly by point mutations in p. falciparum dihydrofolate reductase (pfdhfr) and dihydropteroate synthase (pfdhps) target genes. to study the origin and evolution of pyrimethamine resistance on the indian subcontinent, microsatellite markers flanking the pfdhfr gene were mapped. here we describe the characteristics of gene ... | 2009 | 19786603 |
| wash-resistance and field efficacy of olyset net, a permethrin-incorporated long-lasting insecticidal netting, against anopheles minimus-transmitted malaria in assam, northeastern india. | the long-lasting insecticidal nets are ready-to-use, pretreated nets, which do not require retreatment for 4-5 years. olyset nets that are made of high-density polyethylene monofilament yarn with 2% w/w permethrin incorporated (corresponding to 1 g/m(2)) are type-2 in which insecticide is incorporated into the polymers and are wash resistant. in these, insecticide migrates to the surface of the netting fiber to be bioavailable against mosquitoes and other insect pests. study site and objectives: ... | 2010 | 19874188 |
| molecular evidence for the involvement of anopheles nivipes (diptera: culicidae) in the transmission of plasmodium falciparum in north-eastern india. | the anopheles philippinensis and an. nivipes mosquitoes that form part of the an. annularis species group are morphologically very similar and difficult to differentiate as adults. in consequence, researchers generally refer to all field-collected individuals of these species simply as the an. philippinensis-nivipes species complex. although this species complex is understood to play a role in the transmission of parasites causing human malaria in north-eastern india, the identity of the exact s ... | 2010 | 20659394 |
| anti-malarial herbal remedies of northeast india, assam: an ethnobotanical survey. | malaria is a serious public health problem in the north-eastern region of india including assam, in view of development of chloroquine resistant plasmodium falciparum. there is need for alternative and affordable therapy. | 2010 | 21029768 |
| anaemia & expression levels of cd35, cd55 & cd59 on red blood cells in plasmodium falciparum malaria patients from india. | severe anaemia in plasmodium falciparum (pf) associated malaria is a leading cause of death despite low levels of parasitaemia. in an effort to understand the pathogenesis of anaemia we studied expression level of rbc complement regulatory proteins, cr1 (cd35), cd55 and cd59 with haemoglobin status in a group of malaria cases from assam, goa and chennai, and in healthy controls. | 2011 | 21727667 |
| laboratory wash-resistance and field evaluation of deltamethrin incorporated long-lasting polyethylene netting (netprotect(-«)) against malaria transmission in assam, north-east india. | north-east india is co-endemic for plasmodium falciparum and p. vivax malaria, and disease transmission is perennial and persistent. this study reports the results of a field-based village scale trial of deltamethrin incorporated long-lasting polyethylene netting (netprotect(-«)) conducted in p. falciparum predominant pocket of assam, north-east india to assess operational feasibility, acceptability and sustainability against disease vectors and malaria transmission. the study monitored the resi ... | 2011 | 21679681 |
| Antibody response to allelic variants of 19kDa fragment of MSP-1: Recognition of a variant and protection associated with ethnicity in Assam, India. | Evidence suggests association of anti MSP-1(19) antibodies with protection from clinical malaria. However, the target epitope was reported to vary with respect to response to conserved or variant epitopes in different studies. We have investigated here humoral response of naturally exposed individuals of Tibeto-Burman and Austro-Asiatic ethnic groups to E-TSR and Q-KNG variants of MSP-1(19) in comparison to whole merozoite extract (WME) of local strain of Plasmodium falciparum in a longitudinal ... | 2011 | 22133506 |
| prevalence of multiple drug-resistant plasmodium falciparum malaria cases in northeast india. | two numbers of plasmodium falciparum field isolates from gossingpara, runikhata area in chirang district of assam had shown multiple mutations in pfcrt-dhfr-dhps gene (up to seven mutations: one mutation in pfcrt gene, three mutations in pfdhfr gene and three mutations in pfdhps gene). similarly, two cases in bat camp, miao area under changlang district of arunachal pradesh had shown a total of eight mutations, of which one mutation in pfcrt gene, three mutations in pfdhfr gene, three mutations ... | 2017 | 28303837 |
| mutational prevalence of chloroquine resistance transporter gene among plasmodium falciparum field isolates in assam and arunachal pradesh, india. | the present study aims to find out the mutational prevalence of plasmodium falciparum chloroquine resistance transporter (pfcrt) gene in assam and arunachal pradesh, india. | 2016 | 27080771 |
| seasonal prevalence of malaria vectors in sonitpur district of assam, india. | | 2007 | 17722870 |
| malaria situation in forest-fringed villages of sonitpur district (assam), india bordering arunachal pradesh during an outbreak. | epidemiological and entomological studies were undertaken in forest-fringed villages in sonitpur district (assam) bordering arunachal pradesh, india to assess the malaria situation. blood smears (thick and thin) were collected from the fever cases through door-to-door survey. both the blood smears stained with giemsa were used for malaria parasite detection. slide positivity rate (spr) was recorded as 39.1% with predominance of plasmodium falciparum (97.1%) infections. children between 5 and 14 ... | 2007 | 17896624 |
| sequence diversity and natural selection at domain i of the apical membrane antigen 1 among indian plasmodium falciparum populations. | the plasmodium falciparum apical membrane antigen 1 (ama1) is a leading malaria vaccine candidate antigen. the complete ama1 protein is comprised of three domains where domain i exhibits high sequence polymorphism and is thus named as the hyper-variable region (hvr). the present study describes the extent of genetic polymorphism and natural selection at domain i of the ama1 gene among indian p. falciparum isolates. | 2007 | 18031585 |
| therapeutic efficacy of artemether-lumefantrine in uncomplicated falciparum malaria in india. | artemisinin-based combination therapy (act) is the treatment of choice for uncomplicated falciparum malaria. artemether-lumefantrine (al), a fixed dose co-formulation, has recently been approved for marketing in india, although it is not included in the national drug policy for treatment of malaria. efficacy of short course regimen (4 x 4 tablets of 20 mg artemether plus 120 mg lumefantrine over 48 h) was demonstrated in india in the year 2000. however, low cure rates in thailand and better plas ... | 2009 | 19454000 |
| role of an. culicifacies as a vector of malaria in changing ecological scenario of northeastern states of india. | malaria has become endemic and subject of concern in most part of the india especially northeastern states of india. surveys before 2000 revealed that anopheles minimus was major vector responsible for transmission of malaria in this region followed by an. dirus and an. fluviatilis. however, recent studies indicate replacement of an. minimus vector by an. culicifacies due to different ecological changes and change in landuse pattern etc. the objective of present study was to explore the vectoria ... | 2017 | 27681550 |
| population genetic study of plasmodium falciparum parasites pertaining to dhps gene sequence in malaria endemic areas of assam. | plasmodium falciparum malaria parasite had developed resistance to almost all the currently used antimalarial drugs. the purpose of the study was to come across the genetic distances in p. falciparum dhps gene sequences circulating in assam. a partial fragment of p. falciparum dhps gene containing major single nucleotide polymorphisms associated with sulphadoxine resistance were amplified and sequenced. thereafter specific bioinformatics tools like bioedit v7.0.9, clustalw in mega 5, dnasp versi ... | 2015 | 26068343 |
| detection of point mutation in plasmodium falciparum atpase6 gene associated with artemisinin resistance from assam and arunachal pradesh. | resistance against partner drugs of artemisinin has been reported from different parts of india. the study aims to find out the single nucleotide polymorphisms in plasmodium falciparum atpase6 gene associated with artemisinin resistance. | 2014 | 25540959 |
| genetic polymorphisms associated with sulphadoxine-pyrimethamine drug resistance among plasmodium falciparum field isolates in malaria endemic areas of assam. | the emergence of antimalarial drug resistance malaria parasite is widespread in north eastern region of india. during january 2012-december 2013, we conducted active surveillance for detection of antifolate resistance-associated genetic polymorphisms in plasmodium falciparum malaria parasite from different malaria endemic areas of assam. | 2017 | 25511211 |
| genetic polymorphism and amino acid sequence variation in plasmodium falciparum glurp r2 repeat region in assam, india, at an interval of five years. | the r2 repeat region of glurp has been reported as a good genetic marker for plasmodium falciparum genotyping. proper knowledge of the extent and nature of p. falciparum genetic diversity using highly immunogenic r2 repeat region in malaria-endemic areas is a crucial element to understand various aspects related to immunity acquisition and disease pathogenesis. | 2014 | 25416405 |
| genotyping of chloroquine resistant plasmodium falciparum in wild caught anopheles minimus mosquitoes in a malaria endemic area of assam, india. | we validated the feasibility of using plasmodium falciparum, the human malaria parasite, dna present in wild caught vector mosquitoes for the characterization of chloroquine resistance status. house frequenting mosquitoes belonging to anopheles minimus complex were collected from human dwellings in a malaria endemic area of assam, northeast india and dna was extracted from the head-thorax region of individual mosquitoes. anopheles minimus complex mosquitoes were identified to species level and s ... | 2014 | 25382483 |
| correlation of molecular markers, pfmdr1-n86y and pfcrt-k76t, with in vitro chloroquine resistant plasmodium falciparum, isolated in the malaria endemic states of assam and arunachal pradesh, northeast india. | the mechanism of chloroquine (cq) resistance in plasmodium falciparum is not clearly understood. however, cq resistance has been shown to be associated with point mutations in pfcrt and pfmdr1. these genes encode for digestive vacuole transmembrane proteins pfcrt and pgh1, respectively. the present study was carried out to analyze the association of pfcrt-k76t and pfmdr1-n86y mutations with cq resistance in northeast indian p. falciparum isolates. 115 p. falciparum isolates were subjected to in ... | 2014 | 25105963 |
| the association of il-8-251t/a polymorphism with complicated malaria in karbi anglong district of assam. | amongst host genetic factors, cytokine gene polymorphism can be anticipated to be an important factor as qualitative, quantitative and time of secretion play an important role in disease outcome. we have investigated association of cytokine promoter snps with risk of plasmodium falciparum malaria and disease severity in a case control study in malaria endemic karbi anglong district of assam, india. frequency of il-8-251t/a (p=0.03 and p=0.01) and tgf-β1-509c/t (p=0.02 and p=0.03) was higher in m ... | 2014 | 24290435 |
| prioritizing areas for malaria control using geographical information system in sonitpur district, assam, india. | to identify the malaria hot spots at health subcentre level in an endemic district using a geographical information system (gis). the results will be useful for rapid retrieval of malaria information, and to prioritize malaria control efforts in identified hot spots. | 2013 | 23701814 |