| geographic diversity of adult t-cell leukemia/lymphoma in brazil. the brazilian atll study group. | we describe 195 cases of adult t-cell leukemia/lymphoma (atll) reported to the national registry of t-cell malignancies in brazil between 1994 and 1998. we compared the effect of demographic differences and clinical features of 150 consecutive atll cases in different regions of this diverse country. at diagnosis, the predominant clinical sub-type was the acute type (60%), followed by lymphoma (22%), chronic (10%) and smoldering (8%) types. although we expected that different sub-types would be p ... | 1999 | 10495418 |
| human t lymphotropic virus type i (htlv-i) infection in neurological patients in salvador, bahia, brazil. | htlv-i infection represents a major health concern in endemic areas throughout the world, such as salvador, the main city of bahia state, with socio-demographic characteristics similar to sub-saharan african cities, located in the northeast of brazil. in order to provide an estimate of the frequency distribution, and range of neurological manifestations potentially related to htlv-i infection in this city, we conducted a cross-sectional clinical-epidemiological study to determine the prevalence ... | 1999 | 10426153 |
| risk factors for human t cell lymphotropic virus type i among injecting drug users in northeast brazil: possibly greater efficiency of male to female transmission. | it was observed in the city of salvador, state of bahia, the highest seroprevalence of human t cell lymphotropic virus type 1 (htlv-i) infection in brazil as demonstrated by national wide blood bank surveys. in this paper, we report results of an investigation of drug use and sexual behavior associated with htlv-i infection among male and female injecting drug users (idus) in salvador. a cross sectional study was conducted in the historical district of salvador from 1994-1996 (projeto brasil-sal ... | 1999 | 10029907 |
| vertical transmission of htlv-i/ii: a review. | the vertical transmission of the human t-cell lymphotropic virus type i (htlv-i) occurs predominantly through breast-feeding. since some bottle-fed children born to carrier mothers still remain seropositive with a frequency that varies from 3.3% to 12.8%, an alternative pathway of vertical transmission must be considered. the prevalence rate of vertical transmission observed in japan varied from 15% to 25% in different surveys. in brazil there is no evaluation of this form of transmission until ... | 1998 | 9876439 |
| adult t-cell leukemia/lymphoma in northeastern brazil: a clinical, histopathologic, and molecular study. | the state of bahia in the northeastern coast of brazil is a region in which htlv-i infection is endemic. this study investigated the characteristics of 28 htlv-i-associated lymphomas/leukemias in this region. htlv-i-infection diagnosis was based on serologic study, southern blot analysis, and polymerase chain reaction (pcr) in neoplastic tissue. the main clinical differences between these lymphomas and adult t-cell leukemia (atl) cases from other endemic areas were as follows. the mean age was 4 ... | 1999 | 10235516 |
| [infection and disease caused by the human t cell lymphotropic viruses type i and ii in brazil]. | htlv-i/ii infection is present in all regions of brazil, but its prevalence varies according to the geographical area, being higher in bahia, pernambuco and pará. it has been estimated that brazil has the highest absolute number of infected individuals in the world. blood donors screening and research conducted with special groups (indigenous population of brazil, iv drug users and pregnant women) are the major sources of information about these viruses in our country. htlv-i causes adult t cell ... | 2002 | 12621671 |
| seroepidemiology of human t-cell lymphotropic virus type i/ii in northeastern brazil. | we investigated the prevalence of human t-lymphotropic virus i/ii (htlv-i/ii) infection in bahia, a state in northeastern brazil. healthy individuals (n = 327) and patients (n = 337) with a variety of diseases were screened for antibodies to htlv-i/ii using an enzyme immunoassay and western blot. the overall prevalence among healthy subjects was 1.8% (six of 327); among patients it was 18.4% (62 of 337). patients with aids had the highest prevalence of htlv-i/ii infection, 22.7% (20/88), followe ... | 1993 | 8315579 |
| htlv-i/ii as a common etiology of myelopathies in bahia, brazil. | infection by human t-cell lymphotrophic virus type i (htlv-i) is associated with a myelopathy known as tropical spastic paraparesis (tsp). the prevalence of htlv-i infection was found to be high in a pilot study in bahia, brazil. in the present study, among patients with myelopathy of unclear etiology, 27% (17/62) were immunoblot reactive to htlv-i/ii (serum and csf), but none of 40 consecutive patients seen at the neurological clinic and having a well-established neurological diagnosis had dete ... | 1996 | 9070387 |
| seroprevalence of hiv, htlv-i/ii and other perinatally-transmitted pathogens in salvador, bahia. | generation of epidemiological data on perinatally-transmitted infections is a fundamental tool for the formulation of health policies. in brazil, this information is scarce, particularly in northeast, the poorest region of the country. in order to gain some insights of the problem we studied the seroprevalence of some perinatally-transmitted infections in 1,024 low income pregnant women in salvador, bahia. the prevalences were as follow: hiv-1 (0.10%), htlv-i/ii (0.88%), t.cruzi (2.34%). t.palli ... | 1995 | 8599064 |
| characteristics of chronic pain and its impact on quality of life of patients with htlv-1-associated myelopathy/tropical spastic paraparesis (ham/tsp). | we describe the prevalence of chronic pain and their characteristics in 43 consecutive patients presenting with human t-lymphotropic virus type i (htlv-1) associated myelopathy (ham) /tropical spastic paraparesis in salvador, brazil. | 2011 | 20842011 |
| prevalence of human t-cell lymphotropic virus type 1 infection in hospitalized patients with tuberculosis. | reports have suggested that human t-cell lymphotropic virus type 1 (htlv-1) may influence immunological response and therefore the clinical course of tuberculosis (tb) in co-infected individuals. we wished to determine the prevalence of htlv-1 infection among hospitalized patients in salvador, brazil, a region endemic for both htlv-1 infection and latent tb infection. | 2009 | 19919770 |
| htlv-1 and myelopathy in salvador (northeastern brazil): a case control study. | the principal aim of the study was to determine the degree of association between cerebrospinal fluid (csf) that is positive for htlv-1 and myelopathy in salvador, brazil. from the same hospital, twenty-eight cases of myelopathy and twenty-eight cases showing no neurological disorder were studied using blind selection matched 1:1 by age and sex. the twenty-eight pairs underwent htlv-1 serology tests. in those with a positive result, anti-htlv-1 antibodies were investigated in the csf. the elisa ... | 1993 | 8147743 |
| correlation between polymorphisms at interleukin-6 but not at interleukin-10 promoter and the risk of human t lymphotropic virus type i-associated myelopathy/tropical spastic paraparesis in brazilian individuals. | htlv-1 is the etiologic agent of atl and ham/tsp. the majority of htlv-1-infected individuals remain asymptomatic, indicating that the infection alone is not sufficient to cause the diseases. it has been reported that cytokine gene polymorphisms, including polymorphisms at il-6 and il-10 gene, might be important. we analyzed snp in the promoter region of the il-6: -174, -572, -597, and -634 positions, and il-10: -592 position to evaluate the role of these polymorphisms in the ham/tsp pathogenesi ... | 2008 | 19040291 |
| phylogenetic and molecular analysis of htlv-1 isolates from a medium sized town in northern of brazil: tracing a common origin of the virus from the most endemic city in the country. | salvador-bahia has the highest prevalence of htlv-1 infection in brazil; about 2% of the population is infected. in this city, the prevalence of htlv in pregnant women is 1%. there is no data of the htlv-1 prevalence in others cities of the bahia's recôncavo, where the population has similar social and demography characteristics to those from salvador. our aim was to evaluate the seroprevalence of htlv in pregnant women in cruz das almas-bahia, a medium-sized city from the bahia's recôncavo. all ... | 2008 | 18814252 |
| htlv-i associated myelopathy in salvador (northeastern brazil). | recent studies of tropical spastic paraparesis have confirmed the existence of human t-cell leukemia virus type-1 (htlv-i) in several tropical areas of the world. in order to determine the role of htlv-i as an etiologic agent of myelopathies in salvador, we conducted a clinical and serological study in 43 patients with non-traumatic and non-tumoral myelopathies. we found 9 patients with htlv-i associated myelopathy (ham) which points to a new endemic area of ham. | 1992 | 1308389 |
| study of autoantibodies in patients with keratoconjunctivitis sicca infected by the human t cell lymphotropic virus type 1. | human t cell lymphotropic virus type 1 (htlv-1) is endemic in many regions of the world, including brazil, and has been associated to several immunological manifestations such as arthritis, uveitis, dermatitis and sjögren's syndrome. this study was intended to evaluate the frequency of autoantibodies in patients infected with htlv-1 and manifesting keratoconjunctivitis sicca (kcs). htlv-1 patients with kcs, enrolled in a reference ambulatory of the city of salvador, were tested for autoantibodie ... | 2010 | 19639323 |
| the close relationship between south african and latin american htlv type 1 strains corroborated in a molecular epidemiological study of the htlv type 1 isolates from a blood donor cohort. | it has been difficult to explain why all htlv-1 sequences in salvador, a city in the northeast of brazil, belong to the transcontinental (a) subgroup of the cosmopolitan (a) subtype, since according to historical data the vast majority of slaves brought to brazil (through salvador) came from west africa, where only the western african subgroup (c) has been found. to shed more light on this subject we conducted a phylogenetic analysis of 23 isolates from blood donors of salvador. dna was extracte ... | 2007 | 17506606 |
| [htlv-1 associated myelopathies in the city of salvador, bahia]. | chronic myelopathy associated with human t-lymphotropic virus type i (htlv-i) has been described in several endemic areas in brazil. in salvador, 102 patients with myelopathy were screened for htlv-i/ii by elisa and western blot assays. we found 36 patients with htlv-i/ii associated myelopathy confirming the high prevalence of ham in salvador. the initial complaint of our patients were urinary urgency, back pain and progressive unsteadiness on walking. on examination all of them had a spastic pa ... | 1994 | 7893204 |
| re-mapping the molecular features of the human immunodeficiency virus type 1 and human t-cell lymphotropic virus type 1 brazilian sequences using a bioinformatics unit established in salvador, bahia, brazil, to give support to the viral epidemiology studies. | the analysis of genetic data for human immunodeficiency virus type 1 (hiv-1) and human t-cell lymphotropic virus type 1 (htlv-1) is essential to improve treatment and public health strategies as well as to select strains for vaccine programs. however, the analysis of large quantities of genetic data requires collaborative efforts in bioinformatics, computer biology, molecular biology, evolution, and medical science. the objective of this study was to review and improve the molecular epidemiology ... | 2007 | 17426875 |
| htlv type 1 molecular study in brazilian villages with african characteristics giving support to the post-columbian introduction hypothesis. | we performed an htlv epidemiological study of 986 individuals from 17 villages from the same state of salvador, the city with the highest htlv-1 prevalence in brazil. the htlv-1 prevalence was 3.85%, 1.56%, and 1.23% in three villages. phylogenetic analysis of the ltr region demonstrated that all positive samples analyzed belonged to the transcontinental subgroup of the htlv-1 cosmopolitan subtype. three of the new htlv-1 sequences formed a well-supported clade within one of the latin american c ... | 2008 | 18462080 |
| prevalence and risk of blood-borne and sexually transmitted viral infections in incarcerated youth in salvador, brazil: opportunity and obligation for intervention. | to determine the prevalence of sexually transmitted and blood-borne infections among incarcerated adolescents in salvador, brazil, we interviewed 300 incarcerated youth aged 11-18 years to participate in a physical examination and to provide a blood sample to test for hiv-1, hepatitis b and c viruses exposure, human t-cells lymphotrophic virus, and syphilis. overall prevalence was anti-hiv, 0.34%; anti-hbc, 11.1%; hbsag, 2.4%; anti-hcv, 6.4%; htlv, 1.09%; and syphilis, 3.4%. the majority (86.3%) ... | 2008 | 18500658 |
| urinary symptoms associated with human t-cell lymphotropic virus type i infection: evidence of urinary manifestations in large group of htlv-i carriers. | to describe the frequency of urologic manifestations in human t-cell lymphotropic virus type i (htlv-i) seropositive individuals from salvador and other cities in bahia, brazil, with or without clinical htlv-i-associated myelopathy/tropical spastic paraparesis (ham/tsp). | 2007 | 17482910 |
| increased risk of tuberculosis with human t-lymphotropic virus-1 infection: a case-control study. | to investigate whether infection with human t-lymphotropic virus type 1 (htlv-1) increases the risk of tuberculosis. | 2005 | 16284541 |
| infective dermatitis associated with the human t cell lymphotropic virus type i in salvador, bahia, brazil. | infective dermatitis associated with human t cell lymphotropic virus type i (htlv-i) infection is a chronic, relapsing eczema of childhood. | 2005 | 15889351 |
| globin haplotypes of human t-cell lymphotropic virus type i-infected individuals in salvador, bahia, brazil, suggest a post-columbian african origin of this virus. | the city of salvador, bahia, brazil, has sociodemographic characteristics similar to some african cities. up to now, it has had the highest prevalence of human t-cell lymphotropic virus type i (htlv-i) infection (1.74%) in the country. to investigate which strains of htlv-i are circulating in salvador, we studied isolates from 82 patients infected with htlv-i: 19 from the general population, 21 from pregnant women, 16 from intravenous drug users, and 26 from patients and their family attending a ... | 2003 | 12869844 |
| erectile dysfunction and htlv-i infection: a silent problem. | the human t-lymphotropic virus type i (htlv-i) is a retrovirus associated with a chronic myelopathy known as htlv-i-associated myelopathy or tropical spastic paraparesis (ham/tsp). the main objective was to assess the frequency of erectile dysfunction (ed) in htlv-i-infected individuals from salvador and other cities from bahia, brazil, as well as to verify if sexual dysfunction correlates with urinary symptoms and overall neurological impairment. from january 2001 to april 2004, 218 htlv-i carr ... | 2005 | 15875060 |
| human t-cell lymphotropic virus type 1 infection among pregnant women in northeastern brazil. | an evaluation of human t-cell lymphotropic virus type 1 (htlv-1) infection among 6754 pregnant women in salvador, bahia, brazil using enzyme-linked immunosorbent assay, western blot analysis, and polymerase chain reaction assay found a rate of infection of 0.84% (57 of 6754 women). epidemiologic and obstetric data on the htlv-1-positive pregnant women were analyzed and compared with data on a control group of htlv-1-negative pregnant women. the mean age of the htlv-1-positive women was 26.2 year ... | 2001 | 11391171 |
| co-infection with htlv-1 is associated with a shorter survival time for hiv-1-infected patients in bahia, brazil. | co-infection with htlv-1 reaches 20% among patients infected by hiv-1 in bahia, brazil. to evaluate its impact on survival, we conducted a retrospective, case-control study involving 198 patients (63 cases). co-infection was associated with parenteral exposure (p = 0.0001) and female sex (p = 0.02). co-infected patients had a shorter mean survival (1849 days) than controls (2430 days, p = 0.001), regardless of sex or baseline cd4 cell count. in bahia, brazil, co-infection with hiv-1 and htlv-1 i ... | 2001 | 11600839 |
| human t cell lymphotropic virus type 1 (htlv-1) proviral load of htlv-associated myelopathy/tropical spastic paraparesis (ham/tsp) patients according to new diagnostic criteria of ham/tsp. | | 2011 | 21567429 |
| the impact of human t-cell lymphotropic virus i infection on clinical and immunologic outcomes in patients coinfected with hiv and hepatitis c virus. | hiv, hepatitis c (hcv), and human t-cell lymphotropic virus i (htlv-1) are associated with high global burdens of disease, notably in resource-poor locales. they share similar routes of transmission and cause chronic infections with associated morbidity. we performed a cross-sectional study to assess the impact of htlv-1 infection on clinical outcomes in hiv/hcv-coinfected patients. | 2011 | 21857319 |
| clinical manifestations in individuals with recent diagnosis of htlv type i infection. | human t-lymphotropic virus type 1 (htlv-1) is known to cause htlv-associated myelopathy (ham)/tropical spastic paraparesis and adult t cell leukemia. a growing body of evidence links htlv-1 infection with an increasing spectrum of disease, including uveitis, periodontal disease, arthropathy, sicca syndrome, and neurologic deficits. | 2011 | 21388871 |
| seroprevalence and molecular epidemiology of htlv-1 isolates from hiv-1 co-infected women in feira de santana, bahia, brazil. | htlv-1/hiv-1 co-infection is associated with severe clinical manifestations, marked immunodeficiency, and opportunistic pathogenic infections, as well as risk behavior. salvador, the capital of the state of bahia, brazil, has the highest htlv-1 prevalence (1.74%) found in brazil. few studies exist which describe this co-infection found in salvador and its surrounding areas, much less investigate how these viruses circulate or assess the relationship between them. to describe the epidemiological ... | 2010 | 20929351 |
| the association of infection and clinical severity in sickle cell anaemia patients. | sickle cell anaemia (sca) patients have a high risk of infection. we retrospectively investigated the prevalence of infection among sca patients from bahia, brazil. a total of 1415 sca patients were studied between 1995 and 2009: 190 (13.4%) had hepatitis c virus (hcv), 67 (4.7%) had human t-lymphotropic virus type i (htlv-i), 44 (3.1%) had hepatitis b virus (hbv), 40 (2.8%) had chagas' disease, 11 (0.8%) had human immunodeficiency virus (hiv), and 5 (0.4%) had syphilis. patients with hcv infect ... | 2011 | 21216418 |
| keratoconjunctivitis sicca of human t cell lymphotropic virus type 1 (htlv-1) infected individuals is associated with high levels of htlv-1 proviral load. | a high htlv-1 proviral load is found in htlv-1-associated diseases, mainly ham/tsp. however, the association between proviral load and keratoconjunctivitis sicca (kcs) has not been well established. | 2011 | 21868282 |
| analysis of cutaneous lymphomas in a medical center in bahia, brazil. | to evaluate the frequency of the different types of cutaneous lymphoma (cl) in 1 university hospital in brazil and compare this frequency with those observed in other countries. | 2013 | 23955453 |
| infective dermatitis associated with human t-cell lymphotropic virus type 1: evaluation of 42 cases observed in bahia, brazil. | infective dermatitis associated with human t-cell lymphotropic virus type 1 (htlv-1; idh) is a chronic recurrent eczema affecting htlv-1-infected children. the epidemiological and dermatological characteristics of idh are described, and their principal diagnostic criteria are reevaluated. | 2012 | 22467669 |
| Impact of depression on quality of life in people living with human T cell lymphotropic virus type 1 (HTLV-1) in Salvador, Brazil. | PURPOSE: A previous study found the prevalence of depression in HTLV-1-infected patients to be approximately 30%, but few studies have attempted to correlate depression with quality of life (QOL) in these patients. The present study investigates the association between depression and QOL in people living with HTLV-1. METHODS: A clinical-epidemiological questionnaire, the Mini International Neuropsychiatric Interv ... | 2011 | 22109110 |
| hepatitis c virus infection and spontaneous clearance in htlv-1 and hiv co-infected patients in salvador, bahia, brazil. | while 20-40% of patients with hepatitis c virus (hcv) monoinfection will spontaneously clear the virus, less is known regarding clearance with coinfections. hcv, human immunodeficiency virus (hiv), and human t-cell lymphotrophic virus 1 and 2 (htlv-1/2) coinfection occurs due to shared routes of transmission and is prevalent in brazil. | 2016 | 26254690 |
| prevalence and risk factors for human t-lymphotropic virus type 1 (htlv-1) among maintenance hemodialysis patients. | infection with the human t-cell lymphotropic virus type 1 (htlv-1), although asymptomatic in most cases, can lead to potentially grave consequences, such as adult t-cell leukemia-lymphoma and htlv-1-associated myelopathy / tropical spastic paraparesis. its prevalence varies widely across different populations and geographic regions. a population-based study in the city of salvador, located in the northeast region of brazil, showed an overall prevalence of htlv-1 seropositivity of 1.7%. blood bor ... | 2017 | 28202003 |