| outbreak of central nervous system disease associated with hand, foot, and mouth disease in japan during the summer of 2000: detection and molecular epidemiology of enterovirus 71. | few outbreaks of the serious enterovirus 71 (ev71) infections, which affect the central nervous system (cns), had been reported in japan before 2000. during june through august 2000, a patient died of pulmonary edema caused by brainstem encephalitis accompanied by ev71-induced hand, foot, and mouth disease (hfmd), and many patients complicated by serious cns disease, including paralysis, were hospitalized in a restricted area in hyogo prefecture, japan (k-area). during the same period, endemics ... | 2002 | 12437029 |