Publications

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cystic echinococcosis in the xinjiang/uygur autonomous region, people's republic of china. i. demographic and epidemiologic data.demographic and epidemiologic data on those factors potentially related to the prevalence and transmission of hydatid disease caused by echinococcus granulosus were collected in 1987 from each household in 85 villages in the two communities of yuanhucun and ershilidian within hutubi county in the xinjiang/uygur autonomous region, prc, with additional questionnaire data collected from approximately 40 households randomly selected from each of 16 villages within those communities. yuanhucun and er ...19902382094
genotypes of echinococcus granulosus in animals from yushu, northeastern china.echinococcus granulosus is the causative agent of cystic echinococcosis with medical and veterinary importance worldwide. the aim of this study was to determine the genotype distribution of e. granulosus in animals in yushu, qinghai province, northeastern china. the mitochondrial nicotinamide adenine dinucleotide+hydrogen (nadh) dehydrogenase subunit 1 (nad1) and cytochrome c oxidase subunit 1 (cox1) genes from 30 echinococcosis isolates were analyzed by sequence alignment, generating two unique ...201323289393
independent evaluation of a canine echinococcosis control programme in hobukesar county, xinjiang, china.the xinjiang uyghur autonomous region in northwest china is one of the world's most important foci for cystic echinococcosis. domestic dogs are the main source for human infection, and previous studies in xinjiang have found a canine echinococcus spp. coproelisa prevalence of between 36% and 41%. in 2010 the chinese national echinococcosis control programme was implemented in xinjiang, and includes regular dosing of domestic dogs with praziquantel. six communities in hobukesar county, northwest ...201525661801
epidemiological studies on cystic echinococcosis in china--a review.in the four decades from 1951 to 1990, the six provinces or autonomous regions (xinjiang, gansu, qinghai, ningxia, xizang and nei monggol) reported a total of 26,065 surgical cases of hydatid disease, most of which were reported in the recent decade. about one third of the patients was children and adolescents under 15 years old. so far, cystic hydatid infections of local origin have been confirmed in 22 provinces, autonomous regions and municipalities in the whole nation. findings of x-ray exam ...19957546341
cystic echinococcosis in the xinjiang/uygur autonomous region, people's republic of china. ii. comparison of three levels of a local preventive and control program.a project to compare different levels of a hydatid disease control program was instigated and evaluated in 16 randomly selected villages in the xinjiang/uygur autonomous region, prc (china). factors tested included the effect of: 1) the role of a village hydatid disease control officer, 2) the use of praziquantel-medicated "bait" tablets for treatment of echinococcus granulosus tapeworms in dogs, and 3) the use of educational materials for children and adults. evaluation of contrasting treatment ...19912052848
a pilot study for control of hyperendemic cystic hydatid disease in china.cystic hydatid disease (chd) is a global parasitic zoonosis caused by the dog tapeworm, echinococcus granulosus. the disease is hyperendemic in western china because of poor economic development; limited community knowledge of chd; widespread, small-scale household animal production; home killing of livestock; and the feeding of dogs with uncooked offal.200919859535
genotyping of human cystic echinococcosis in xinjiang, pr china.the xinjiang uygur autonomous region, multi-ethnic province in northwestern china, is one of the most important foci of human cystic echinococcosis (ce) in the world. two echinococcus granulosus genotypes (g1 and g6) are known to infect the intermediate hosts in this area but, to date, the source of the human infection remains unclear. the current study aimed to genetically analyse 67 hydatid cysts removed from 47 ce patients for which epidemiological, clinical and serological data were also rec ...200616836793
prevalence of cystic echinococcosis in slaughtered sheep as an indicator to assess control progress in emin county, xinjiang, china.hydatid disease imposing serious threat on human health and great loss in live¬stock pastoralism remains a major public health problem in western china. to assess and monitor the effect of control program on transmission dynamics, we used the prevalence of cystic echinococcosis in slaughtered sheep at slaughterhouse as an indicator during the period of 2007 to 2013 in emin county, xinjiang uygur autonomous region, china. the results showed a significant decline trend of prevalence in all age gro ...201526174832
genetic polymorphisms of echinococcus tapeworms in china as determined by mitochondrial and nuclear dna sequences.the genetic polymorphisms of echinococcus spp. in the eastern tibetan plateau and the xinjiang uyghur autonomous region were evaluated by dna sequencing analyses of genes for mitochondrial cytochrome c oxidase subunit 1 (cox1) and nuclear elongation factor-1 alpha (ef1a). we collected 68 isolates of echinococcus granulosus sensu stricto (s.s.) from xinjiang and 113 isolates of e. granulosus s. s., 49 isolates of echinococcus multilocularis and 34 isolates of echinococcus shiquicus from the tibet ...201019800346
epidemiological evaluations of the efficacy of slow-released praziquantel-medicated bars for dogs in the prevention and control of cystic echinococcosis in man and animals.to assess the epidemiological efficacy of type srp iii slow-released praziquantel-medicated bars for dogs in the prevention and control of cystic echinococcosis in man and livestock, praziquantel-medicated bars were implanted subcutaneously in over 90% of dogs in villages in north xinjiang, china, where cystic echinococcosis is highly endemic. after implantation, infection rate of echinococcus granulosus in dogs, specific antibodies in children and prevalence of echinococcosis in one-year-old la ...200516231860
frequency distribution of echinococcus granulosus hydatid cysts in sheep populations in the xinjiang uygur autonomous region, china.age-prevalence and age-intensity data of echinococcus granulosus hydatid cysts in sheep populations were collected in an abattoir in the xinjiang uygur autonomous region, people's republic of china. the frequency distribution of the larval cysts per sheep was empirically described by the negative binomial model, with parameter k being 0.5273. a mathematical model for the life cycle of e. granulosus was applied to the collected data and the results show that the infection pressure on sheep was 0. ...19921441193
short report: echinococcus granulosus from xinjiang, pr china: cdnas encoding the eg95 vaccine antigen are expressed in different life cycle stages and are conserved in the oncosphere.the eg95-based vaccine protects sheep from infection with the dog tapeworm echinococcus granulosus. the eg95 encoding gene is a member of a multigene family, several members of which are expressed in the oncosphere, believed to be the target of immunity induced by the vaccine. e. granulosus exhibits extensive intraspecific (strain) variation, and variability of the eg95 gene in different isolates of e. granulosus may directly impact the effectiveness of the eg95-based vaccine. we analyzed the eg ...200312556145
morphological and molecular characteristics of echinococcus multilocularis and echinococcus granulosus mixed infection in a dog from xinjiang, china.the xinjiang plateau of western china has been shown to have a high prevalence for human cystic echinococcosis (ce) caused by echinococcus granulosus, and human alveolar echinococcosis (ae) caused by echinococcus multilocularis. the domestic dog is suspected to be the primary definitive host for the transmission of both e. granulosus and e. multilocularis to humans in this locality. seventeen of 30 stray dogs from hejing county of xinjiang were found positive for e. granulosus post mortem, and o ...200616616990
cloning, homological analysis and construction of eg95 xinjiang strain dna vaccine.to study the structure specificity of echinococcus granulosus 95 (eg95) gene and the open reading frame (orf) of the full-length cdna sequence in xinjiang, northwestern china and construct eg95 xinjiang strain dna vaccine.200314627516
frequency distribution of echinococcus granulosus in dog populations in the xinjiang uygur autonomous region, china.age-prevalence and age-intensity data of echinococcus granulosus in dog populations were collected in four counties in the xinjiang uygur autonomous region, people's republic of china. the frequency distribution of the parasite per dog was adequately described by the negative binomial model, with parameter k being 0.0571. the mathematical model of the life cycle of e. granulosus constructed by roberts et al. (1986--parasitology, vol. 92, pages 621-641) was used to estimate the epidemiologic para ...19921413455
[monthly deworming in dogs for echinococcosis control in two counties of xinjiang uygur autonomous region].to verify the application and effectiveness of monthly deworming for all dogs in the control of echinococcus granulosus infection.200824818364
[rflp analysis of dna from echinococcus granulosus collected from four provinces/autonomous region in china].a fragment of the ribosomal rna gene of schistosoma mansoni psm889 and two dna fragments specific to echinococcus granulosus phd5 and peg18 have been used as dna probes to assess the extent of genetic variability within e. granulosus. the dna analysis, including restriction endonuclease digestion and southern blot hybridization with the probes, did not demonstrate any genetic variation among e. granulosus collected from sheep in xinjiang, qinghai, gansu and ninxia. similarly, there was no geneti ...19937909504
mitochondrial genomic markers confirm the presence of the camel strain (g6 genotype) of echinococcus granulosus in north-western china.twenty-eight isolates of e. granulosus, collected from humans at surgery, and a range of intermediate hosts, including sheep, cattle and camels from abattoirs in north and south xinjiang uygur autonomous region, people's republic of china, were analysed for dna sequence variation within regions of the mitochondrial cytochrome c oxidase i (coi) and nadh dehydrogenase subunit i (ndi) genes. the isolates were categorized into 2 distinct and uniform genotypic groupings, based on the sequences obtain ...19989481771
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