| [dna sequence of surface antigen gene gp195 of two chinese isolates of plasmodium falciparum from hainan]. | amplification of dna sequence of surface antigen gene, block ii of gp195 from 2 chinese isolates of plasmodium falciparum fcc 7801/hn b3 and fcc m21/hn from hainan, china, was established by using the polymerase chain reaction. a comparison of the 154 peptide sequences of the 2 chinese isolates showed that they were identical, but there was a difference of 10 peptides among the established 154 peptides between the two chinese isolates and mad 20 (a papua new guinea isolate). the need to determin ... | 1992 | 1394915 |
| a 5-year surveillance of sensitivity in vivo of plasmodium falciparum to pyronaridine/sulfadoxine/pyrimethamine in diaoluo area, hainan province. | the surveillance of sensitivity of p. falciparum to pyronaridine/sulfadoxine/pyrimethamine has been carried out in diaoluo area in hainan province where chloroquine-resistant falciparum malaria is endemic, covering an area of 406 square kilometers, with a population of 3745 in 1986. from 1986 all outpatients diagnosed as falciparum malaria were administered with pnd/s/p as the only antimalarial. in vivo sensitivity of p. falciparum was measured in some patients who were treated in hospital. it w ... | 1991 | 1948261 |
| [in vivo sensitivity of plasmodium falciparum to piperaquine phosphate assayed in linshui and baisha counties, hainan province]. | fifty-three cases of falciparum malaria in linshui county, baisha county and sanya municipality were treated with piperaquine phosphate at a total dose of 1.5g base over 3 days in july to december, 1986. the mean defervescence time was 36 +/- 20.7h; the mean asexual parasite clearance time was 69.7 +/- 20.9h. at 14-28d follow-up recrudescence was observed with asexual parasitemia in 7 of the 47 cases, showing ri resistance to piperaquine. gametocytemia was positive in 35 cases (74.5%) during the ... | 1989 | 2686856 |
| a field trial of a fluorometric in vitro drug sensitivity test for plasmodium falciparum in hainan island. | | 1989 | 2692223 |
| [malaria situation in china, 1988. advisory committee on parasitic diseases]. | in 1988, the number of malaria cases reported was 134.2 thousand (taiwan province not included). comparing with 210.6 thousand cases reported in 1987, a decrease of 36.3% was noted. based on data reported by each county in the country, about 950.7 million people in 2,541 counties/cities were living in areas where malaria incidence was less than 0.1 per 1,000 (including originally malaria-free areas as well as areas free from the disease); 96.6 million people in 207 counties/cities with an incide ... | 1989 | 2699279 |
| [chloroquine-resistant malignant malaria in hainan island: report of 10 years' study]. | | 1986 | 3527436 |
| [a successive survey on the sensitivity of p. falciparum patients to chloroquine by in vitro microtechnic and in vivo test on hainan island]. | | 1985 | 3902404 |
| [sensitivity of plasmodium falciparum to piperaquine in baoting county, hainan island]. | | 1985 | 3915732 |
| [resistance to piperaquine phosphate in hainan islanders with pernicious malaria]. | | 1985 | 3931880 |
| randomised comparative study of mefloquine, qinghaosu, and pyrimethamine-sulfadoxine in patients with falciparum malaria. | a prospective trial in 80 patients randomly allocated to four antimalarial treatment regimens--mefloquine plus pyrimethamine-sulfadoxine ('fansidar'); mefloquine plus qinghaosu; mefloquine, fansidar, and qinghaosu; and qinghaosu alone--was carried out on hainan island, china, in patients with chloroquine-resistant falciparum malaria. a radical cure with slight side-effects was obtained with mefloquine plus fansidar; the addition of qinghaosu greatly increased the rate of parasite clearance with ... | 1984 | 6150365 |
| infectivity of a strain of plasmodium falciparum from hainan, people's republic of china, to different anophelines. | | 1981 | 7020446 |
| [investigation on the sensitivity of plasmodium falciparum to chloroquine at qianjia, hainan island (author's transl)]. | | 1982 | 7047100 |
| changes in the resistance of plasmodium falciparum to chloroquine in hainan, china. | in 1979, in view of the widespread resistance of plasmodium falciparum to chloroquine in the island of hainan, china, it use as an antimalarial was suspended throughout the island. a longitudinal survey of the chloroquine-sensitivity of p. falciparum was carried out over the period 1981-91 to investigate whether its resistance had changed from the 1979 level. in-vitro assays were carried out every 2-3 years, while in-vivo tests were performed annually over the period 1981-83 and also in 1991. re ... | 1995 | 7554020 |
| [malaria situation in the people's republic of china in 1994. advisory committee on malaria, moph]. | according to case reporting system, the number of malaria cases amounted to 62,101 in the country (taiwan province not included) in 1994, showing a mean incidence of 5,292 per a hundred thousand, and 43 deaths were caused by the disease. an increase of 3,532 malaria cases was revealed while comparing with the data of 1993. a total of 1,083 billion population resided in areas where there were no reported malaria cases or the incidence was below 0.01%, 80 million in areas with incidence of 0.01-0. ... | 1995 | 8556787 |
| [cloning and sequence analysis of the gene encoding the second region of msa1 from three chinese isolates of plasmodium falciparum]. | gene encoding the second region of merozoite surface antigen (msa1-r2) of three chinese isolates of plasmodium falciparum from hainan, yunnan and anhui were amplified by pcr, cloned into m13 and sequenced. comparison among msa1-r2 sequences from different isolates of p. falciparum shows that there is no difference among the three chinese isolates. the sequence of msa1-r2 of the chinese isolates are highly homologous with that of wellcome from west africa. the sequence flanking the upstream of th ... | 1996 | 9388985 |
| sequence analysis and genotypes of glutamate rich protein of plasmodium falciparum isolates from different malaria endemic areas in china. | to sequence the gene encoding glutamate rich protein (glurp) and identify the genotypes of geographically different plasmodium falciparum (p. f) isolates from china. | 2002 | 12046543 |
| [changes in chloroquine resistance of plasmodium falciparum in hainan province]. | to observe the variation in resistance of plasmodium falciparum after the cessation of chloroquine medication. | 1999 | 12563813 |
| sequence analysis of the msp 1 gene of plasmodium falciparum isolates from hainan, china. | to obtain the complete sequence and analyze the diversity of the msp 1 molecule from the chinese isolates of plasmodium falciparum. | 1999 | 12563862 |
| [sequence analyzing and genotyping of the gene encoding glutamate rich protein of geographically different plasmodium falciparum isolates obtained from different malaria endemic areas]. | to sequence a gene encoding glurp and identify the genotypes of geographically different plasmodium falciparum isolates from yunnan and hainan provinces, china. | 2000 | 12567458 |
| [practicability of ifat using plasmodium cynomolgi and plasmodium falciparum antigens in different malarious areas]. | to compare the practicability of ifat in different malarious areas using plasmodium cynomolgi(p.c.) and plasmodium falciparum(p.f.) antigens. | 2000 | 12567477 |
| [malaria situation in the people's republic of china in 1999]. | although the middle and lower reaches of changjiang river were consecutively stricken by severe flood in 1998 and 1999, the transmission of malaria was not frequent and prevalence of the disease was basically stable with no reports of outbreaks in the above areas, which was attributed to the intensification of malaria surveillance, prompt implementation of integrated measures including mosquito control and chemoprophylaxis, as well as the zoophilous trend of anopheles sinensis, the vector in the ... | 2000 | 12567683 |
| [genotypes of merozoite surface protein 2 of plasmodium falciparum in different malaria endemic areas]. | to determine the genotypes and distribution of msp2 of plasmodium falciparum isolates in yunnan and hainan provinces, china. | 2001 | 12572012 |
| [gene typing of merozoite surface protein 1 of plasmodium falciparum isolates from hainan province]. | to identify the genotype of merozoite surface protein 1 (msp1) of plasmodium falciparum isolates from hainan province. | 2001 | 12572013 |
| [malaria situation in the people's republic of china in 2002]. | this summary was made on the basis of the annual reports of malaria control from the professional institutions in the 21 provinces/municipality/autonomous region (p/m/a). the number of malaria cases reported in the country was 35,298 in the year 2002 and the incidence rate was 0.348/10,000, an increase of 68.2% than that of the last year and the largest increase since 1994. the total number of suspected cases was 136,902, and the death toll due to malaria was 42. based on the numbers of malaria ... | 2003 | 14628361 |
| decreased prevalence of the plasmodium falciparum chloroquine resistance transporter 76t marker associated with cessation of chloroquine use against p. falciparum malaria in hainan, people's republic of china. | the use of chloroquine treatment for plasmodium falciparum malaria was abandoned in china in 1979 because of widespread drug resistance. subsequent studies found decreases in the prevalence of chloroquine-resistant strains. to evaluate these decreases and assess the current status of chloroquine sensitivity in hainan, china, we determined the prevalence of the p. falciparum chloroquine resistance transporter (pfcrt) 76t marker in the dna of blood samples collected from 1978 to 2001. results show ... | 2005 | 15827277 |
| [malaria situation in the people's republic of china in 2003]. | total 40,681 malaria cases and 129,147 suspected cases with 52 deaths were reported by the case reporting system in 910 counties of 21 provinces/municipality/autonomous region (p/m/a) in 2003, and the annual incidence was 0.39/10000, an increase of 15.3% than that of the last year, which is the third year that malaria incidence consecutively increased since 2001. based on a baseline survey in the project funded by the global fund to fight aids, tuberculosis and malaria (gfatm), the estimated num ... | 2005 | 16566200 |
| [establishment of in vitro microtest for determining sensitivity of plasmodium falciparum to pyronaridine]. | to establish an in vitro microtest for determining the sensitivity of plasmodium falciparum to pyronaridine. | 2006 | 16862905 |
| [malaria situation in the people' s republic of china in 2004]. | in 2004, 38,972 malaria cases and 106,704 suspected cases with 31 deaths were reported by the annual case reporting system in 1,005 counties of 23 provinces/municipality/autonomous region (p/ m/a) and the annual incidence was 0.38/10 000, a decrease of 4.2% than that of the last year, which is the year that the disease was slightly rolled back after consecutively increased since 2001. as an important development of the case reporting system, the internet reporting system started in 2004, majorit ... | 2006 | 16866130 |
| no genetic bottleneck in plasmodium falciparum wild-type pfcrt alleles reemerging in hainan island, china, following high-level chloroquine resistance. | chloroquine-resistant plasmodium falciparum was highly prevalent in hainan, china, in the 1970s. twenty-five years after cessation of chloroquine therapy, the prevalence of p. falciparum wild-type pfcrt alleles has risen to 36% (95% confidence interval, 22.1 to 52.4%). the diverse origins of wild-type alleles indicate that there was no genetic bottleneck caused by high chloroquine resistance. | 2008 | 17954685 |
| [malaria situation in the people's republic of china in 2006]. | totally 64,178 malaria cases and 52,082 suspected cases with 38 deaths were reported by the annual case reporting system in 917 counties of 23 provinces/municipality/autonomous regions (p/m/a) in 2006, and the annual incidence was 0.50/10,000. through the internet reporting system 60,382 malaria cases were reported from 1,097 counties of 30 p/m/a. the number of malaria cases and the rank of p/m/a were basically in concordance in the two systems. among the 917 counties with reported malaria cases ... | 2007 | 18441886 |
| no pfatpase6 s769n mutation found in plasmodium falciparum isolates from china. | artemisinin and its derivatives have been used for falciparum malaria treatment in china since late 1970s. monotherapy and uncontrolled use of artemisinin drugs were common practices for a long period of time. in vitro tests showed that the susceptibility of plasmodium falciparum to artemisinins was declining in china. a concern was raised about the resistance to artemisinins of falciparum malaria in the country. it has been reported that in vitro artemisinin resistance was associated with the s ... | 2008 | 18606023 |
| [efficacy of dihydroartemisinin-piperaquine and artemether-lumefantrine in the treatment of uncomplicated falciparum malaria in hainan, china]. | to assess the therapeutic efficacy of the combinations dihydroartemisinin-piperaquine and artemether-lumefantrine in treating uncomplicated falciparum malaria cases in an area with high level resistance of plasmodium falciparum to chloroquine in hainan province. | 2008 | 18637586 |
| [malaria situation in the people's republic of china in 2007]. | total 50148 malaria cases and 83551 suspected cases with 18 deaths were reported by the annual case reporting system in 1182 counties of 23 provinces/municipality/autonomous region (p/m/a) in 2007, and the annual incidence was 0.39/10000. through the internet reporting system 46,988 malaria cases were reported from 1097 counties of 31 p/m/a. the number of malaria cases and the rank of p/m/a were basically in concordance in two systems. among the 1182 counties with reported malaria cases, 26 coun ... | 2008 | 19288908 |
| molecular assessment of plasmodium falciparum resistance to antimalarial drugs in china. | in china, chloroquine (cq) and sulfadoxine-pyrimethamine (sp) were abandoned for the treatment of falciparum malaria 20 years ago due to resistance. subsequent field studies showed a trend of declining cq and sp resistance in the country. the main purpose of this study was to analyse the molecular markers of antimalarial resistance and thereby to assess the possibility of reintroduction of cq or sp for falciparum malaria treatment. | 2009 | 19772548 |
| diversity and prevalence of the c-terminal region of plasmodium falciparum merozoite surface protein 1 in china. | malaria continues to be a significant health concern for regions of southeastern asia. scientists have focused much effort on the development and regional testing of a vaccine against the most virulent of the pathogens that cause the disease, plasmodium falciparum. the 19kda cooh-terminal region of the merozoite surface protein 1 (pfmsp1-19) is considered to be a potentially important component of a malaria vaccine and yet, to date, there is little data from china with regard to pfmsp1-19 divers ... | 2010 | 20709011 |
| [malaria situation in the people's republic of china in 2009]. | totally 14,491 malaria cases and 59 741 suspected cases with 12 deaths were reported by the annual case reporting system in 1171 counties of 23 provinces/municipalities/autonomous regions (p/m/a) in 2009, and the annual incidence was 0.11/10,000. through the internet reporting system, 14,140 malaria cases were reported from 956 counties of 30 p/m/ a. the number of malaria cases and the rank of p/m/a were basically in concordance in the two systems. among the 1171 counties with reported malaria c ... | 2011 | 21823314 |
| analysis of var genes cloned from a plasmodium falciparum isolate in china. | to analyse the var gene repertoire and characterise the chondroitin sulphate a (csa)-binding activity of the duffy-binding like (dbl) domains encoded by the var2csa gene of a plasmodium falciparum (p. falciparum) isolate in hainan province, china. | 2012 | 22221747 |
| a cost-effectiveness analysis of plasmodium falciparum malaria elimination in hainan province, 2002-2012. | in hainan province, china, great achievements in elimination of falciparum malaria have been made since 2010. there have been no locally acquired falciparum malaria cases since that time. the cost-effectiveness of elimination of falciparum malaria has been analyzed in hainan province. there were 4,422 falciparum malaria cases reported from 2002 to 2012, more cases occurred in males than in females. from 2002 to 2012, a total of 98.5 disability-adjusted life years (dalys) were reported because of ... | 2015 | 26438030 |
| genetic diversity of plasmodium vivax population before elimination of malaria in hainan province, china. | hainan province is one of the most severe endemic regions with high transmission of plasmodium falciparum and plasmodium vivax in china. however, the incidence of p. falciparum and p. vivax has dropped dramatically since 2007 and a national elimination malaria programme (nemp) was launched after 2010. to better understand the genetic information on p. vivax population before elimination of malaria in hainan province, the extent of genetic diversity of p. vivax isolates in hainan province was inv ... | 2015 | 25888891 |
| eliminating plasmodium falciparum in hainan, china: a study on the use of behavioural change communication intervention to promote malaria prevention in mountain worker populations. | in the island of hainan, the great majority of malaria cases occur in mountain worker populations. using the behavioral change communication (bcc) strategy, an interventional study was conducted to promote mountain worker malaria prevention at a test site. this study found the methods and measures that are suitable for malaria prevention among mountain worker populations. | 2014 | 25017319 |
| epidemic distribution and variation of plasmodium falciparum and plasmodium vivax malaria in hainan, china during 1995-2008. | hainan province is the main area threatened by malaria in china. however, the epidemiologic patterns of malaria in this region are not yet defined. in this study, we determined the spatio-temporal distribution and variation of plasmodium falciparum and plasmodium vivax malaria in hainan during 1995-2008 by using wavelet and cluster quantitative approaches. the results indicated a decreasing secular trend and obvious seasonal fluctuation of malaria in hainan. in addition, the characteristic annua ... | 2012 | 22869636 |
| evaluation of the population structure and genetic diversity of plasmodium falciparum in southern china. | yunnan and hainan provinces are the two major endemic regions for plasmodium falciparum malaria in china. however, few studies have investigated the characteristics of this parasite. therefore, this study aimed to evaluate the genetic diversity and population structure of p. falciparum to predict the geographic origin of falciparum malaria. | 2015 | 26194795 |
| sensitivity of plasmodium falciparum to antimalarial drugs in hainan island, china. | pyronaridine and artesunate have been shown to be effective in falciparum malaria treatment. however, pyronaridine is rarely used in hainan island clinically, and artesunate is not widely used as a therapeutic agent. instead, conventional antimalarial drugs, chloroquine and piperaquine, are used, explaining the emergence of chloroquine-resistant plasmodium falciparum. in this article, we investigated the sensitivity of p. falciparum to antimalarial drugs used in hainan island for rational drug t ... | 2015 | 25748707 |
| lessons from malaria control to elimination: case study in hainan and yunnan provinces. | reduction patterns of plasmodium falciparum and p. vivax malaria transmission and the role of an integrated strategy of case management and vector control are compared between different ecological zones. the epidemiology of malaria in hainan and yunnan provinces was disparate, even though distinct malaria control strategies have been adapted to different situations based on risk group, vector behaviours, local health infrastructure, and environmental conditions. the island hainan appears to be v ... | 2014 | 25476881 |
| distinctive origin and spread route of pyrimethamine-resistant plasmodium falciparum in southern china. | southeast asia (the thailand-cambodia border) has been considered the primal epicenter for most antimalarial drug resistance; however, numerous molecular epidemiological studies have successively reported multiple independent origins of sulfadoxine-pyrimethamine (sp) resistance-associated plasmodium falciparum dhfr (pfdhfr) and pfdhps alleles in other areas. to better understand the origin and evolutionary pathway of the sp resistance in southeast asia, a total of 374 p. falciparum field isolate ... | 2014 | 24145550 |
| [malaria situation in the people's republic of china in 2010]. | totally 7,855 malaria cases and 34,082 suspected cases with 19 deaths were reported by the annual case reporting system in 1,191 counties of 23 provinces/municipalities/autonomous regions (p/m/a) in 2010 and the annual incidence was 0.06/10000. through the internet reporting system 7433 malaria cases were reported from 974 counties of 31 p/m/a. the number of malaria cases and the ranking of p/m/a were basically in concordance between the two systems. among the 1,191 counties with reported malari ... | 2011 | 24822335 |