Publications

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the influence of organizational jurisdiction, organizational attributes, and training measures on perceptions of public health preparedness in alberta.objectives: recent international events including the h1n1 influenza pandemic and the rising incidence of west nile virus throughout north america have brought critical attention to the canadian public health system and how prepared the system is to respond to various types of contemporary public health threats. the current work assessed the association of organizational jurisdiction, organizational attributes, and training opportunities with three different measures of public health preparednes ...201121541784
west nile virus finally debuts in british columbia 10 years after its introduction to north america.abstract since its first detection in new york (1999), west nile virus (wnv) has spread across the united states and canada with the first activity reported in canada in 2001. by 2004, wnv had been detected almost in every province of canada and the contiguous regions of the united states with the exception of british columbia (bc), this despite being detected in alberta in 2003 and washington as early as 2002. in august 2009, two human cases were serologically found to have wnv infection. they ...201021028958
screening of organ and tissue donors for west nile virus by nucleic acid amplification--a three year experience in alberta.west nile virus (wnv)-specific nucleic acid amplification testing (naat) of organ and tissue donors remains controversial. we report three years of wnv donor screening in alberta canada using naat. between 2003 and 2005, 1549 initial specimens were received. a valid negative result was issued within the specified turnaround time on 1531 (98.8%). the initial naat was successful for 1393 samples (90%), while repeat testing using an alternate naat resolved a further 126 samples. for 12 of 14 donors ...200818727691
modelling geographic variations in west nile virus.this paper applies a method for modelling the spatial variation of west nile virus (wnv) in humans using bird, environmental and human testing data.200617120875
clinical utility of commercial enzyme immunoassays during the inaugural season of west nile virus activity, alberta, canada.west nile virus (wnv) has spread rapidly across north america, creating a need for rapid and accurate laboratory diagnosis on a large scale. immunoglobulin m (igm) capture enzyme immunoassays (eia) became commercially available in the summer of 2003, but limited data are available on their clinical performance. consolidated human wnv diagnostic testing for the province of alberta, canada, at the public health laboratory permitted a large-scale evaluation of the assays, covering a wide clinical s ...200516145128
nucleic acid testing for west nile virus rna in plasma enhances rapid diagnosis of acute infection in symptomatic patients.although nucleic acid amplification testing (naat) for west nile virus (wnv) is useful in screening blood donors, such methods have not been studied in symptomatic patients. for diagnosis of wnv infection, 1.0 ml of plasma was tested by naat, and wnv-specific immunoglobulin m was assayed. of 276 wnv cases, 191 were tested by both serology and naat. of these, 86 (45.0%), 111 (58.1%), and 180 (94.2%) were detected by naat, serology, and combined naat and serology, respectively. naat-based screenin ...200616619182
public health preparedness in alberta: a systems-level study.recent international and national events have brought critical attention to the canadian public health system and how prepared the system is to respond to various types of contemporary public health threats. this article describes the study design and methods being used to conduct a systems-level analysis of public health preparedness in the province of alberta, canada. the project is being funded under the health research fund, alberta heritage foundation for medical research.200617194305
maculopapular rash and tremor are associated with west nile fever and neurological syndromes.the clinical features associated with west nile virus (wnv) infections are described based on data collected from history forms submitted with samples during a province-wide wnv testing programme. age 40-59 years (or 1.7, p<0.008), residence in the southeast of alberta (or 4.2, p<0.001), maculopapular rash (or 8.6, p<0.001) or tremor (or 3.6, p<0.001) were independently associated with wnv infection.200717435190
the rash of west nile virus infection. 200515911857
ecological determinants of avian influenza virus, west nile virus, and avian paramyxovirus infection and antibody status in blue-winged teal (anas discors) in the canadian prairies.the canadian prairies are one of the most important breeding and staging areas for migratory waterfowl in north america. hundreds of thousands of waterfowl of numerous species from multiple flyways converge in and disperse from this region annually; therefore this region may be a key area for potential intra- and interspecific spread of infectious pathogens among migratory waterfowl in the americas. using blue-winged teal (anas discors, bwte), which have the most extensive migratory range among ...201626540179
climate change and west nile virus in a highly endemic region of north america.the canadian prairie provinces of manitoba, saskatchewan, and alberta have reported the highest human incidence of clinical cases of west nile virus (wnv) infection in canada. the primary vector for wvn in this region is the mosquito culex tarsalis. this study used constructed models and biological thresholds to predict the spatial and temporal distribution of cx. tarsalis and wnv infection rate in the prairie provinces under a range of potential future climate and habitat conditions. we selecte ...201323880729
modeling monthly variation of culex tarsalis (diptera: culicidae) abundance and west nile virus infection rate in the canadian prairies.the canadian prairie provinces of alberta, saskatchewan, and manitoba have generally reported the highest human incidence of west nile virus (wnv) in canada. in this study, environmental and biotic factors were used to predict numbers of culex tarsalis coquillett, which is the primary mosquito vector of wnv in this region, and prevalence of wnv infection in cx. tarsalis in the canadian prairies. the results showed that higher mean temperature and elevated time lagged mean temperature were associ ...201323880728
laboratory confirmed positive cases of equine west nile virus in alberta in 2003. 200515825514
calgary experience with west nile virus neurological syndrome during the late summer of 2003.between august 25 and september 25, 2003 seven patients with west nile virus neurological manifestations were identified through the hospital neurology consultation services in calgary, alberta, canada. three of the seven patients were treated with interferon alpha-2b (ifn alpha-2b). in this report we document the clinical characteristics of these seven cases.200415198443
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