| serologic abnormalities in spontaneous and drug-induced systemic lupus erythematosus. | extensive serologic changes occur in systemic lupus erythematosus (sle) which are probably secondary to unknow primary cause(s). the new zealand hybrid mouse model most likely has a viral-induced disease and does not show many of the clinical features of the human disease. the best example of human sle which provides a clue to etiology is the drug-induced type, particularly that due to procainamide. in these patients it is possible to study the development of serologic changes prior to the onset ... | 1975 | 50452 |
| naturally occurring murine leukemia viruses in wild mice: characterization of a new "amphotropic" class. | a new class of murine leukemia viruses, isolated from wild mus musculus trapped in california, is described. these viruses, designated "amphotropic," replicate in mouse, rabbit, mink, human, guinea pig, and rat cells, but not in hamster, quail, or duck cells. they show n-tropism for mouse cells, and do not trigger the xc cell response. they are distinct by interference and virus neutralization testing from the previously recognized mouse-tropic and xenotropic mulv classes. mouse-tropic viruses o ... | 1976 | 59816 |
| inhalation anthrax in a home craftsman. | inhalation anthrax with complicating subarachnoid hemorrhage due to simultaneous infection with two capsular biotypes of bacillus anthracis of different virulence for the mouse is reported. the patient, a home craftsman, acquired his infection from imported animal-origin yarn. | 1978 | 101438 |
| amphotropic host range of naturally occuring wild mouse leukemia viruses. | seven murine leukemia virus field isolates (uncloned) from wild mice (musmusculus) of four widely separated areas in southern california show an unusually wide in vitro host range. they replicate well in human, feline, canine, guinea pig, rabbit, rat, and mouse cells, whereas bovine, hamster, and avian cells are resistant. since this host range includes that of both mouse tropic (ecotropic) and xenotropic murine leukemia viruses, they are designated as "amphotropic". no purely xenotropic virus c ... | 1976 | 181592 |
| prevalence of murine mammary tumor virus antibody and antigens in normal and tumor-bearing feral mice. | approximately 20% of normal male and female feral mice (mus musculus) from areas with populations having either high [lake casitas (lc) and la puente] or low (bouquet canyon) spontaneous lymphoma incidence expressed murine mammary tumor virus (mumtv) gp52 in specific tissues. sera from a low percentage (6%) of mice from the same trapping areas contained precipitating antibody specific for mumtv. although moderate to high levels of mumtv gp52 were expressed in mammary tumor tissues of 3 of 7 lc m ... | 1978 | 210292 |
| ecology of california encephalitis viruses on the del mar va peninsula. i. virus isolations from mosquitoes. | the ecology of california encephalitis viruses was studied on the del mar va peninsula. adult mosquitoes were collected weekly from may to october of 1971 and monthly from may to october of 1972, using cdc miniature light traps with dry ice. floodwater mosquitoes were assayed for virus in suckling mice or cell cultures. in 1971 over 77,000 mosquitoes were processed, resulting in 33 virus isolations. in 1972, over 106,000 were processed and 63 virus strains were recovered. of the 1971 strains, al ... | 1975 | 234205 |
| cryptococcosis in columbiformes at the san diego zoo. | two cases of cryptococcosis in columbiformes exhibited at the san diego zoo are described. the organism isolated from the first case had morphological, chemical and temperature growth characteristics of c. neoformans. the culture from case 2 died before it could be examined biochemically or by mouse inoculation. | 1978 | 357757 |
| prevalence of toxoplasma gondii antibodies in wild and domestic animals in northern california. | wild and domestic animals from 3 geographic-climatologic areas in northern california were tested for antibodies against toxoplasma gondii. a total of 2,796 serum samples representing 37 species of wild mammals, 35 species of wild birds, and 5 species of domestic animals were tested by the indirect hemagglutination test. of 1,174 wild mammal serums tested, 10.8% were positive, which compared with 14.7% of the 1,221 domestic mammal serums. of 229 wild carnivores tested, 45% were seropositive, inc ... | 1976 | 977457 |
| the bcg for measuring cardiac output in a california gray whale. | resting cardiac output can be predicted reasonably accurately from body mass in man and other mammals. we measured the stroke volume of a 4,500-kg whale and found that iberall's formula holds true even when body mass is very large. in addition, the bcg acceleration trace and cardiac indices were remarkably similar to those of 20-gram and 70-kg mammals, mouse and man. | 1976 | 985341 |
| eimerians in harvest mice, reithrodontomys spp., from mexico, california and new mexico, and phenotypic plasticity in oocysts of eimeria arizonensis. | between may 1979 and august 1991, 48.7% (57/117) of the harvest mice (reithrodontomys spp.) examined from 10 localities in mexico, california and new mexico had coccidian oocysts in their feces. a total of 46.7% (49/105) of the reithrodontomys megalotis examined were positive for coccidian oocysts; this included samples from five states in mexico (47.1%, 8/17), three counties in california (66.7%, 4/6) and two counties in new mexico (45.1%, 37/82); 66.7% (8/12) of the reithrodontomys montanus fr ... | 1992 | 1522549 |
| uptake of environmental contaminants by small mammals in pickleweed habitats at san francisco bay, california. | small mammals were live-trapped in pickleweed (salicornia virginica) habitats near san francisco bay, california in order to measure the uptake of several contaminants and to evaluate the potential effects of these contaminants on the endangered salt marsh harvest mouse (reithrodontomys raviventris). tissues of house mice (mus musculus), deer mice (peromyscus maniculatus), and california voles (microtus californicus) from nine sites were analyzed for chemical contaminants including mercury, sele ... | 1992 | 1586203 |
| toxicity of adductor muscles from the purple hinge rock scallop (crassadoma gigantea) along the pacific coast of north america. | mouse bioassay results of rock scallops occasionally monitored by official agencies of british columbia, washington and california before and/or after algal blooms from 1980-1990 revealed that 24%, 38% and 87% of adductor muscles, whole body and viscera, respectively, were unsafe (greater than or equal to 80 micrograms saxitoxin equivalents/100 g tissue) for human consumption. the safety of adductor muscles could not be predicted from corresponding toxicity levels of the viscera but the absence ... | 1991 | 1926187 |
| lyme disease in california: interrelationship of ixodid ticks (acari), rodents, and borrelia burgdorferi. | the association of immature ixodid ticks, several species of rodents, and the lyme disease spirochete, borrelia burgdorferi johnson, schmid, hyde, steigerwalt & brenner, was studied in two habitats in northern california in spring and summer 1985 and year-round in 1986. a total of 428 rodents were collected from ecotonal chaparral and a woodland-grass-rock outcrop; the former habitat yielded six species, the latter three species. the deer mouse, peromyscus maniculatus (wagner), and the piñon mou ... | 1991 | 1941942 |
| comparative studies on clostridium botulinum type a strains associated with infant botulism in japan and in california, usa. | twenty strains of clostridium botulinum type a associated with infant botulism cases, six in japan and 14 in california, usa, were compared in their characters. all six japanese strains produced medium-sized progenitor toxin (m toxin; mr 300 k) but no hemagglutinin and showed lower 50% infective doses (id50) in the infant mouse test; whereas most american strains produced large-sized progenitor toxin (l + ll toxins; mr 500 k and 900 k) and hemagglutinin in addition to m toxin and showed higher i ... | 1990 | 2129272 |
| primary dapsone-resistant hansen's disease in california. experience with over 100 mycobacterium leprae isolates. | we found that in the years 1978 through 1981 only one of 54 previously untreated patients with hansen's disease was found to harbor dapsone-resistant mycobacterium leprae. that single strain was only partially resistant, ie, it was resistant to 0.0001% dapsone in a mouse diet but not to higher concentrations. during the years 1983 through 1988, m leprae from 47 previously untreated patients presenting to clinics in san francisco, calif, and los angeles, calif, grew in mice. none of these strains ... | 1990 | 2256685 |
| the lesion game: a special communication. | the lesion game is a personal computer program that allows the user to view and study muscle innervations and nerve lesions of the brachial plexus. the core of the program is a table that consists of 44 brachial plexus lesions, 50 muscles, and 2 sensations (for brachium and forearm) of the upper extremity, which are innervated by the brachial plexus. after the program randomly selects a lesion, the user attempts to find the lesion in as few guesses (manual muscle tests) as possible. as muscles a ... | 1989 | 2550973 |
| annual cyclicity of gall stone prevalence in deer mice (peromyscus maniculatus gambelii). | the prevalence of gall stones (100% cholesterol) in a deer mouse (peromyscus maniculatus) population located in siskiyou county, california (usa) was studied on a monthly basis from february 1985 through january 1988. during each year we documented a pronounced annual cyclicity with peak prevalence (31 to 53%) during the winter and low prevalence (2 to 3%) during late summer. gall stone prevalence was not related to sex or age of the animal. the earliest onset of gall stone production and the ma ... | 1989 | 2810546 |
| california serogroup virus infections in wisconsin domestic animals. | a serologic survey and experimental virus transmission studies were done to assess the role of domestic animals as amplifier hosts of la crosse (lacv) and jamestown canyon (jcv) viruses. serum from 319 cows, 88 dogs, 122 equines, 47 swine, 10 goats, and 4 cats were tested for neutralizing antibody to lacv, jcv, trivittatus (tvtv), and snowshoe hare (sshv) viruses. antibody prevalences of lacv, tvtv, and sshv were less than 10% in all species. antibody to jcv was detected in all species except ca ... | 1988 | 3189702 |
| incidence of vibrio cholerae from estuaries of the united states west coast. | the incidence of vibrio cholerae in shellfish, sediment, and waters of california, oregon, and washington was determined during the summer of 1984. samples from 24 distinct estuaries were analyzed qualitatively. v. cholerae non-o1 was found in 23 estuaries and in 44.6% of the 529 samples examined. v. cholerae o1 inaba was isolated from water samples in morro bay, calif. vibrio mimicus was found in 2.3% of the samples. cholera enterotoxin was not found in cell-free filtrates of the 100 isolates t ... | 1987 | 3606111 |
| hemolytic-uremic syndrome--an outbreak in sacramento, california. | between july and november 1982, 14 cases of the hemolytic-uremic syndrome occurred in the sacramento, california, metropolitan area; 9 of the 14 patients lived within a 7.5-mile radius in northeast sacramento, 10 were female, 12 were white non-hispanic and 13 were children with a mean age of 3.6 years. of the 14 patients, 13 were admitted to hospital; 7 required peritoneal dialysis. the 14th child, a 3-month-old white female infant, was found dead in her crib and had renal histopathologic findin ... | 1986 | 3953085 |
| an epidemiologic study of breast cancer. | | 1974 | 4369771 |
| transformation of rat and mouse embryo cells by a new class of carcinogenic compounds isolated from particles in city air. | | 1973 | 4790706 |
| a complex system of chromosomal variation in the pocket mouse, perognathus baileyi merriam. | | 1972 | 5025664 |
| neuropathologic and virus assay studies of experimental california virus encephalitis in the mouse. | | 1971 | 5542544 |
| action of plant extracts on transplanted mouse tumors. screening data. 3. | | 1964 | 5878216 |
| prevalence and distribution of murine mammary tumor virus antigen detectable by immunocytochemistry in spontaneous breast tumors of wild mice. | mouse mammary tumor virus (mumtv) antigens were detected by immunoperoxidase cytochemistry in spontaneous breast tumors of wild mice from two widely separated areas of southern california. eleven of 25 (44%) tumors from lake casitas (lc) mice and 4 of 5 tumors from bouquet canyon mice were positive. included among the tumors lacking detectable mumtv antigen were well-differentiated type a and type b carcinomas as well as tumors with an atypical pattern. in the antigen-positive tumors the distrib ... | 1980 | 6245303 |
| primary dapsone-resistant leprosy in san francisco. | the dapsone sensitivity of strains of mycobacterium leprae from 54 multibacilliferous untreated leprosy patients presenting to the united states public health service hospital in san francisco, california, u.s.a., from 1978 to 1981 was studied by mouse foot pad inoculation. m. leprae from 53 patients were found fully sensitive to dapsone. m. leprae from one patient were resistant to only the lowest dietary level of dapsone, 0.0001%, since growth of the bacilli was inhibited by higher and clinica ... | 1984 | 6399067 |
| survey for evidence of colorado tick fever virus outside of the known endemic area in california. | a virus very similar or identical to colorado tick fever (ctf) virus was recovered from the blood clot of one of 104 black-tailed jack rabbits (lepus californicus) examined during a survey for various zoonotic agents in mammals and ticks from the university of california, hopland field station, mendocino county, california, 1974--79. this is the first reported isolation of a ctf-like virus from l. californicus, and only the second time such a virus has been found in northwestern california. mend ... | 1982 | 7102919 |
| analyses of cytogenetic damage in rodents following exposure to simulated groundwater contaminated with pesticides and a fertilizer. | male fischer 344 rats and female b6c3f1 mice were each exposed through their drinking water to a mixture of pesticides and ammonium nitrate that simulated contaminated groundwater in california (california chemical mixture [ccm]). exposures were for 71 or 91 days, respectively. in addition, b6c3f1 female mice were exposed for 91 days to another pesticide and ammonium nitrate mixture (iowa chemical mixture [icm]) through their drinking water. the spleens were removed from the animals, and the spl ... | 1993 | 7685493 |
| malaria vaccine research. | in our report "activation of raf as a result of recruitment to the plasma membrane" (3 june, p. 1463) (1), panels e and f of figure 1 on page 1464 were incorrect. the correct photographs appear below. in addition, the [see figure in the pdf file] second sentence of the legend to figure 1 should have read, "the raf constructs were tagged at the cooh-terminus with a glu-glu epitope (meympme) (24) for c-raf, or at the nh(2)-terminus with both the glu-glu and the myc (meqkliseedl) (23) epitopes for ... | 1994 | 7864993 |
| verification of causal relationships between listeria monocytogenes isolates implicated in food-borne outbreaks of listeriosis by randomly amplified polymorphic dna patterns. | food and clinical isolates of listeria monocytogenes recovered from four different outbreaks of listeriosis were analyzed by their pcr-based randomly amplified polymorphic dna (rapd) patterns to verify their causal relationships. the generation of dna fingerprints by pcr-based rapd analysis is a fast and sensitive method for the epidemiological tracking and identification of bacteria implicated in food poisoning outbreaks. the l. monocytogenes strains used in the study were obtained from the fol ... | 1994 | 8051257 |
| genetic control of retroviral disease in aging wild mice. | different populations of wild mice (mus musculus domesticus) in los angeles and ventura counties were observed over their lifespan in captivity for expression of infectious murine leukemia virus (mulv) and murine mammary tumor virus (mmtv) and for the occurrence of cancer and other diseases. in most populations of feral mice these indigenous retroviruses were infrequently expressed and cancer seldom occurred until later in life (> 2 years old). mmtv was found in the milk of about 50% of wild mic ... | 1993 | 8125269 |
| mouse pathogenicity studies of nocardia asteroides complex species and clinical correlation with human isolates. | nocardia asteroides complex organisms derived from human specimens between 1979 and 1992 were identified to the species level. of 117 n. asteroides complex organisms, 34 (29%) were n. farcinica, 28 (24%) were n. nova, and 55 (47%) were n. asteroides sensu stricto. an analysis of the specimen sites from which the organisms were derived showed that isolates derived from blood, brain, or bone marrow were more likely to be n. farcinica than the other two species. a study of the virulence of ten stra ... | 1993 | 8354460 |
| reservoir competence of four chaparral-dwelling rodents for borrelia burgdorferi in california. | aspects of the reservoir competence of four rodents for the lyme disease spirochete, borrelia burgdorferi, were evaluated in california. rodents were live-trapped and ear-punch biopsies were cultured during each season. a second set of biopsies was cultured from representative individuals after 2-3 weeks of captivity and the results of culturing biopsies taken on both dates were compared with the results of feeding ixodes pacificus larvae on hosts xenodiagnostically. the prevalence of infections ... | 1996 | 8651378 |
| prevalence of antibodies to arenaviruses in rodents from the southern and western united states: evidence for an arenavirus associated with the genus neotoma. | the objectives of this study were to extend our knowledge of the geographic distribution and rodent host range of arenaviruses in north america. sera from wild rodents collected from the southern and western united states were tested for antibody against tamiami, pichinde, junin, and lymphocytic choriomeningitis viruses, using an indirect fluorescent antibody test. antibody to at least one arenavirus was found in 220 (3.1%) of 7,106 rodents tested. the antibody-positive animals included mus musc ... | 1996 | 8686773 |
| coat color genetics of peromyscus: v. california blonde, a new recessive mutation in the deer mouse. | california blonde is a coat color mutation in the deer mouse (peromyscus maniculatus) discovered among descendants of wild-type animals collected on santa cruz island, california. the phenotype is produced by the presence of brown, rather than black, eumelanin in the pelage and skin. retinal pigmentation is also reduced. the condition is inherited as an autosomal recessive trait. the california blonde gene is nonallelic with the brown (b), blonde (bln), and platinum (plt) mutant genes in this sp ... | 1996 | 8904838 |
| population dynamics of the deer mouse (peromyscus maniculatus) and sin nombre virus, california channel islands. | hantavirus pulmonary syndrome, first documented in 1993, is caused by sin nombre virus (snv), which is carried by the peromyscus species. in 1994, high snv antibody prevalence was identified in deer mice from two california channel islands. we sampled two locations on three islands to estimate mouse population density and snv prevalence. population flux and snv prevalence appear to vary independently. | 1997 | 9284383 |
| mouse and baby chicken virulence of enzootic strains of western equine encephalomyelitis virus from california. | eight enzootic strains of western equine encephalomyelitis (wee) virus isolated from culex tarsalis or aedes melanimon collected in several geographic areas of california were evaluated for their virulence in suckling mice, adult mice, and one-day-old baby chickens. the epidemic fleming strain and the cloned b628(cl 15) variant were used as virulent and avirulent control viruses, respectively, in adult mice. enzootic strains of wee virus were grouped into three phenotypes on the basis of their n ... | 1997 | 9288823 |
| genetic reassortment among viruses causing hantavirus pulmonary syndrome. | in order to determine the frequency and characteristics of reassortment among viruses causing hantavirus pulmonary syndrome (hps), mixed infections were initiated in tissue culture by using two closely related strains of sin nombre virus, cc107 (from eastern california) and nmr11 (from new mexico), which share the same species of rodent host in nature, the deer mouse (peromyscus maniculatus). potential reassortant virus plaques were screened by multiplex rt-pcr, using primers specific for indivi ... | 1998 | 9501041 |
| serologic evidence of infection with ehrlichia spp. in wild rodents (muridae: sigmodontinae) in the united states. | rodent (muridae: sigmodontinae) blood and sera collected from 14 states were tested for seroreactivity to a cultured isolate of the human granulocytic ehrlichiosis (hge) agent by using an indirect immunofluorescence assay. of the 1,240 samples tested, 136 (11%) were found to be reactive at titers of > or = 32. rodents with hge agent-specific antibodies were found in new york (23% of 491 samples; geometric mean endpoint titer [gmt] = 441), connecticut (11% of 100 samples; gmt = 481), california ( ... | 1998 | 9508298 |
| [natural hybridization between two subspecies of the house mouse, mus musculus domesticus and mus musculus castaneus, near lake casitas, california]. | the house mouse mus musculus is a polytypic species, distributed worldwide, with three main subspecies: m. m. musculus in the north-east of eurasia, m. m. castaneus in south-east asia, and m. m. domesticus in europe, the near-east, and africa. this last subspecies may also be found in australia and the americas, where it was brought by european colonization. previous studies, however, have shown the presence of specific antiviral determinants of asian origin in a mouse population at lake casitas ... | 1998 | 9549063 |
| a pax3 polymorphism (t315k) in a family exhibiting waardenburg syndrome type 2. | waardenburg syndrome (ws) is an autosomal-dominant disorder phenotypically characterized by sensorineural hearing loss and pigmentary disturbances. presence of dystopia canthorum is indicative of ws type 1 and results from defects in the pax3 gene, whereas normally located medial canthi is characteristic of type 2 ws (ws2) and is associated with defects in the microphthalmia-associated transcription factor (mift) gene. here a neutral polymorphism is reported in the pax3 gene (t315k) in a family ... | 1998 | 9584079 |
| association of an x-chromosome dodecamer insertional variant allele with mental retardation. | mental retardation is a prominent feature of many neurodevelopmental syndromes. in an attempt to identify genetic components of these illnesses, we isolated and sequenced a large number of human genomic cosmid inserts containing large trinucleotide repeats. one of these cosmids, cos-4, maps to the x-chromosome and contains the sequence of a 7.3-kb mrna. initial polymorphism analysis across a region of repetitive dna in this gene revealed a rare 12-bp exonic variation (<< 1% in non-iii males) hav ... | 1998 | 9702738 |
| ecology and demographics of hantavirus infections in rodent populations in the walker river basin of nevada and california. | to study the ecologic correlates of hantavirus in deer mice (peromyscus maniculatus), we sampled 114 sites in the walker river basin of nevada and california in 1995-1996. blood samples were tested for antibody to hantavirus, and a subset of samples was also tested for virus rna by reverse transcription-polymerase chain reaction. average prevalence of antibody-positive mice was 17%, with heavier males the most likely to be infected. antibody prevalence varied within repeatedly sampled sites from ... | 1998 | 9749642 |
| analysis of select folate pathway genes, pax3, and human t in a midwestern neural tube defect population. | neural tube defects (ntds) are a common birth defect, seen in approximately 1/1,000 births in the united states. ntds are considered a complex trait where several genes, interacting with environmental factors, create the phenotype. using a midwestern ntd population consisting of probands, parents, and siblings from iowa, minnesota, and nebraska, we analyzed a range of candidate genes, including 5,10-methylenetetrahydrofolate reductase (mthfr), folate receptors-alpha (folr1; hereafter abbreviated ... | 1999 | 10332959 |
| desert bighorn sheep mortality due to presumptive type c botulism in california. | during a routine telemetry flight of the mojave desert (california, usa) in august 1995, mortality signals were detected from two of 12 radio-collared female desert bighorn sheep (ovis canadensis) in the vicinity of old dad peak in san bernardino county (california). a series of field investigations determined that at least 45 bighorn sheep had died near two artificial water catchments (guzzlers), including 13 bighorn sheep which had presumably drowned in a guzzler tank. samples from water conta ... | 2000 | 10682765 |
| international telemicroscopy with a 3 mv ultrahigh voltage electron microscope. | the ability for remote microscope operation via a network connection was added recently to the ultrahigh voltage electron microscope (uhvem) in osaka university, and used successfully for the observation of thick biological samples across the pacific ocean by researchers at the national center for microscopy and imaging research (ncmir) at the university of california san diego. high-quality images at video rate were transferred by a satellite link and control signals were transmitted by an isdn ... | 2000 | 10805395 |
| remote sensing and geographic information systems: charting sin nombre virus infections in deer mice. | we tested environmental data from remote sensing and geographic information system maps as indicators of sin nombre virus (snv) infections in deer mouse (peromyscus maniculatus) populations in the walker river basin, nevada and california. we determined by serologic testing the presence of snv infections in deer mice from 144 field sites. we used remote sensing and geographic information systems data to characterize the vegetation type and density, elevation, slope, and hydrologic features of ea ... | 2000 | 10827114 |
| pneumocystosis in wild small mammals from california. | cyst forms of the opportunistic fungal parasite pneumocystis carinii were found in the lungs of 34% of the desert shrew, notiosorex crawfordi (n = 59), 13% of the ornate shrew, sorex ornatus (n = 55), 6% of the dusky-footed wood rat, neotoma fuscipes (n = 16), 2.5% of the california meadow vole, microtus californicus (n = 40), and 50% of the california pocket mouse, chaetodipus californicus (n = 2) caught from southern california between february 1998 and february 2000. cysts were not found in a ... | 2001 | 11310900 |
| the search for lps: 1993-1998. | | 2000 | 11521047 |
| research activities at the loma linda university and proton treatment facility--an overview. | the loma linda university (llu) radiobiology program coordinates basic research and proton beam service activities for the university and extramural communities. the current focus of the program is on the biological and physical properties of protons and the operation of radiobiology facilities for nasa-sponsored projects. the current accelerator, supporting facilities and operations are described along with a brief review of extramural research projects supported by the program. these include s ... | 2001 | 11770533 |
| mhc class ii beta sequence diversity in the deer mouse (peromyscus maniculatus): implications for models of balancing selection. | we studied population polymorphism at a major histocompatibility complex (mhc) class ii beta gene in the deer mouse (peromyscus maniculatus). we found that: (i) a single population of p. maniculatus has significantly higher levels of dna and protein sequence diversity than worldwide samples from homologous genes in other taxa, including humans and mice; and (ii) the genealogy of allelic sequences in p. maniculatus deviates significantly from theoretical expectation under a model of symmetric bal ... | 2001 | 11903890 |
| a founder mutation in artemis, an snm1-like protein, causes scid in athabascan-speaking native americans. | athabascan scid (scida) is an autosomal recessive disorder found among athabascan-speaking native americans and is manifested by the absence of both t and b cells (t(-)b(-)nk(+) scid). we previously mapped the scida gene to a 6.5-cm interval on chromosome 10p. scida fibroblasts were found to have defective coding joint and reduced, but precise signal joint formation during v(d)j recombination. after excluding potential candidate genes, we conducted a combined positional candidate and positional ... | 2002 | 12055248 |
| bear canyon virus: an arenavirus naturally associated with the california mouse (peromyscus californicus). | thirty-four rodents captured in southern california were studied to increase our knowledge of the arenaviruses indigenous to the western united states. an infectious arenavirus was isolated from 5 of 27 california mice but none of the 7 other rodents. analyses of viral nucleocapsid protein gene sequence data indicated that the isolates from the california mice are strains of a novel tacaribe serocomplex virus (proposed name "bear canyon") that is phylogenetically most closely related to whitewat ... | 2002 | 12095441 |
| action of plant extracts on transplanted mouse tumors. screening data. iii. | | 1964 | 14106544 |
| detection and characterization of borrelia bissettii in rodents from the central california coast. | this is the first report of borrelia burgdorferi sensu lato in rodents from san luis obispo county, with most isolates obtained from a previously unreported host, neotoma lepida thomas. b. burgdorferi sensu lato was identified in seven rodent species, including the california vole, microtus californicus peale; dusky-footed woodrat, neotoma fuscipes baird; desert woodrat, neotoma lepida thomas; brush mouse, peromyscus boylii baird; california mouse, peromyscus californicus gambel; deer mouse, per ... | 2004 | 15311469 |
| habitat-related variation in infestation of lizards and rodents with ixodes ticks in dense woodlands in mendocino county, california. | during the spring and early summer of 2002, we examined the relative importance of borrelia-refractory lizards (sceloporus occidentalis, elgaria spp.) versus potential borrelia burgdorferi sensu lato (s.l.)-reservoirs (rodents) as hosts for ixodes pacificus immatures in 14 woodland areas (six oak, five mixed oak/douglas fir, and three redwood/tanoak areas) distributed throughout mendocino county, california. lizards were estimated to serve as hosts for 93-98% of all larvae and > or =99.6% of all ... | 2004 | 15347025 |
| assessment of hydraulic restoration of san pablo marsh, california. | inter-tidal marshes are dynamic diverse ecosystems at the transition zone between terrestrial and ocean environments. geomorphologically, inter-tidal salt marshes are vegetated land-forms at elevations slightly greater than mean tidal levels that have distributed channels formed under ebb (drainage) tidal flows that widen and deepen in the seaward direction. the drainage channels enable tidal flows to circulate sediments and nutrients through the marsh system during normal tidal events, while de ... | 2004 | 15473530 |
| the ucsc proteome browser. | the university of california santa cruz (ucsc) proteome browser provides a wealth of protein information presented in graphical images and with links to other protein-related internet sites. the proteome browser is tightly integrated with the ucsc genome browser. for the first time, genome browser users have both the genome and proteome worlds at their fingertips simultaneously. the proteome browser displays tracks of protein and genomic sequences, exon structure, polarity, hydrophobicity, locat ... | 2005 | 15608236 |
| rodent-flea-plague relationships at the higher elevations of san diego county, california. | rodent-flea-plague relationships were examined at sites located at higher elevations of san diego county during 1991-2002. the most frequently sampled rodents were the california ground squirrel, spermophilus beecheyi, and white-footed mice, peromyscus spp. higher seasonal mean dependent variables (prevalences of squirrels and indices of o. montana), higher mean amounts of seasonal rainfall, and lower seasonal mean ambient temperatures were found at sites during 1991--1993 compared with 2000--20 ... | 2004 | 15707283 |
| ants as first intermediate hosts of mesocestoides on san miguel island, usa. | this study tested the hypotheses that ants (formicidae) function as a first intermediate host of mesocestoides (cestoda: mesocestoididae) and that deer mice (peromyscus maniculatus) develop metacestode infections after ingesting cysticercoid or procercoid-infected ants. field studies were conducted at an island fox (urocyon littoralis littoralis) breeding facility located on san miguel island, california channel islands national park, usa, where > 40% of captive foxes were infected with adult me ... | 2005 | 15831116 |
| seasonal temperature fluctuations induces rapid inactivation of cryptosporidium parvum. | this study measured the inactivation rate of bovine genotype a cryptosporidium parvum oocysts attributable to diurnal oscillations of ambient temperature and solar radiation typical of california rangelands and dairies from spring through autumn. we first measured the relationship between air temperature and the internal temperature of bovine feces exposed to sunlight on commercial operations throughout california. once maximum air temperature exceeded the mid 20 degrees c, diurnal thermal regim ... | 2005 | 16047784 |
| genes encoding catalytic subunits of protein kinase a and risk of spina bifida. | prkaca and prkacb are genes encoding the camp-dependent protein kinase a (pka) catalytic subunits alpha and beta, respectively. pka is known to be involved in embryonic development, as it down-regulates the hedgehog (hh) signaling pathway, which is critical to normal pattern formation and morphogenesis. the pka-deficient mouse model, which has only a single catalytic subunit, provided intriguing evidence demonstrating a relationship between decreased pka activity and risk for posterior neural tu ... | 2005 | 16080189 |
| the snap25 gene as a susceptibility gene contributing to attention-deficit hyperactivity disorder. | the synaptosomal-associated protein of 25 kda gene (snap25) has been suggested as a genetic susceptibility factor in attention-deficit hyperactivity disorder (adhd) based on the mouse strain coloboma. this strain is hemizygous for the snap25 gene and displays hyperactivity that responds to dextroamphetamine, but not to methylphenidate. previously, we reported association of snap25 and adhd using two polymorphisms. to further investigate this gene, we screened the exons for dna variation and geno ... | 2005 | 16088329 |
| longitudinal monitoring of two commercial layer flocks and their environments for salmonella enterica serovar enteritidis and other salmonellae. | between august 20, 2001, and september 17, 2002, 1429 samples including drag swabs, egg belt or egg rollout swabs, fan-blade swabs, rodent organ and intestinal pools, beetle (alphitobius diaperinus) pools, housefly (musca domestica) pools, chicken organ and intestinal pools, and egg pools were obtained for salmonella culture from two flocks from two different commercial layer ranches. the two ranches were purposefully selected for the study based on their previous status of salmonella enteritidi ... | 2005 | 16094821 |
| inhalation of concentrated ambient particulate matter near a heavily trafficked road stimulates antigen-induced airway responses in mice. | the goal of this study was to test the following hypotheses: (1) exposure to mobile emissions from mobile sources close to a heavily trafficked roadway will exacerbate airway inflammation and allergic airway responses in a sensitized mouse model, and (2) the magnitude of allergic airway disease responses will decrease with increasing distance from the roadway. a particle concentrator and a mobile exposure facility were used to expose ovalbumin (ova)-sensitized balb/c mice to purified air and con ... | 2005 | 16259423 |
| small animal imaging center design: the facility at the ucla crump institute for molecular imaging. | the growing number of mouse and rat experiments, coupled with advances in small-animal imaging systems such as micropet, optical, microcat, micromr, ultrasound and microspect, has necessitated a common technical center for imaging small animals. | 2005 | 16261425 |
| the ucsc known genes. | the university of california santa cruz (ucsc) known genes dataset is constructed by a fully automated process, based on protein data from swiss-prot/trembl (uniprot) and the associated mrna data from genbank. the detailed steps of this process are described. extensive cross-references from this dataset to other genomic and proteomic data were constructed. for each known gene, a details page is provided containing rich information about the gene, together with extensive links to other relevant g ... | 2006 | 16500937 |
| absence of respiratory inflammatory reaction of elemental sulfur using the california pesticide illness database and a mouse model. | elemental sulfur, a natural substance, is used as a fungicide. elemental sulfur is the most heavily used agricultural chemical in california. in 2003, annual sulfur usage in california was about 34% of the total weight of pesticide active ingredient used in production agriculture. even though sulfur is mostly used in dust form, the respiratory health effects of elemental sulfur are not well documented. the purpose of this paper is to address the possible respiratory effect of elemental sulfur us ... | 2005 | 16537315 |
| chka and pcyt1a gene polymorphisms, choline intake and spina bifida risk in a california population. | neural tube defects (ntds) are among the most common of all human congenital defects. over the last two decades, accumulating evidence has made it clear that periconceptional intake of folic acid can significantly reduce the risk of ntd affected pregnancies. this beneficial effect may be related to the ability of folates to donate methyl groups for critical physiological reactions. choline is an essential nutrient and it is also a methyl donor critical for the maintenance of cell membrane integr ... | 2006 | 17184542 |
| nod2 variants and antibody response to microbial antigens in crohn's disease patients and their unaffected relatives. | the cdcs1 locus of the c3bir mouse confers severe colitis associated with a decrease in innate immune function and an increase in adaptive t-cell responses to commensal bacterial products. the aim of our study was to determine if defects in innate immunity are similarly associated with increased adaptive immune responses to microbial antigens in crohn's disease patients. | 2007 | 17258734 |
| ectoparasite diversity and exposure to vector-borne disease agents in wild rodents in central coastal california. | a survey of wild rodents was performed in the morro bay area of central coastal california to determine serological and polymerase chain reaction (pcr) prevalence of anaplasma phagocytophilum dumler, barbet, bekker, dasch, palmer, ray, rikihisa, and rurangirwa, borrelia burgdorferi johnson, schmidt, hyde, steigerwalt, and brenner, francisella tularensis mccoy, and yersinia pestis yersin; to describe the ectoparasitic fauna on important vector-borne disease hosts; and to determine whether pathoge ... | 2007 | 17427705 |
| prevalence of factor h-binding protein variants and nada among meningococcal group b isolates from the united states: implications for the development of a multicomponent group b vaccine. | two promising recombinant meningococcal protein vaccines are in development. one contains factor h-binding protein (fhbp) variants (v.) 1 and 2, whereas the other contains v.1 and 4 other antigens discovered by genome mining (5 component [5c]). antibodies against fhbp are bactericidal against strains within a variant group. there are limited data on the prevalence of strains expressing different fhbp variants in the united states. | 2007 | 17436227 |
| a randomised controlled trial evaluating an alternative mouse and forearm support on upper body discomfort and musculoskeletal disorders among engineers. | the aim of this intervention study was to determine the effects of an alternative mouse and/or a forearm support board on the change in upper body discomfort scores and the development of incident musculoskeletal disorders. | 2008 | 17626135 |
| serologic evidence of a rickettsia akari-like infection among wild-caught rodents in orange county and humans in los angeles county, california. | we detected antibodies reactive with rickettsia akari, the etiologic agent of rickettsialpox in humans and in 83 of 359 (23%) rodents belonging to several species, collected in orange county, ca. reciprocal antibody titers >1:16 to r. akari were detected in native mice and rats (peromyscus maniculatus, p. eremicus, and neotoma fuscipes) and in old world mice and rats (mus musculus, rattus rattus, and r. norvegicus), representing the first time that antibodies reactive with this agent have been d ... | 2007 | 18260508 |
| bioportal: ontologies and data resources with the click of a mouse. | | 2008 | 18999306 |
| a randomized controlled trial evaluating an alternative mouse or forearm support on change in median and ulnar nerve motor latency at the wrist. | the purpose of this study was to determine the effects of an alternative mouse and/or a forearm support board on nerve function at the wrist among engineers. | 2009 | 19142961 |
| small mammals collected from a site with elevated selenium concentrations and three reference sites. | small mammals were trapped in july, august, and september 1999 at kesterson reservoir (merced county, ca), a site with elevated concentrations of selenium (se), and at three nearby reference sites. deer mice (peromyscus maniculatus) were the most frequently trapped species at all of the sites, and western harvest mice (reithrodontomys megalotis) and house mice (mus musculus) were also trapped frequently. about half the animals collected from the reference sites were in reproductive condition, co ... | 2009 | 19373506 |
| sensitivity of mouse bioassay in clinical wound botulism. | california has an ongoing epidemic of wound botulism (wb) among injection drug users (idus). we retrospectively studied a cohort of patients with wb and determined the sensitivity of the mouse bioassay-the gold standard laboratory test for confirmation of botulism-in verifying wb. | 2009 | 19435438 |
| california wildfires of 2008: coarse and fine particulate matter toxicity. | during the last week of june 2008, central and northern california experienced thousands of forest and brush fires, giving rise to a week of severe fire-related particulate air pollution throughout the region. california experienced pm(10-2.5) (particulate matter with mass median aerodynamic diameter > 2.5 mum to < 10 mum; coarse ) and pm(2.5) (particulate matter with mass median aerodynamic diameter < 2.5 mum; fine) concentrations greatly in excess of the air quality standards and among the hig ... | 2009 | 19590679 |
| modeling susceptible infective recovered dynamics and plague persistence in california rodent-flea communities. | plague persists as an enzootic in several very different rodent-flea communities around the world. in california, a diversity of rodent-flea communities maintains the disease, and a single-host reservoir seems unlikely. logistic regression of plague presence on climate and topographic variables predicts plague in many localities where it is absent. thus, a dynamic community-based analysis was needed. deterministic susceptible infective recovered (sir) models were adapted for plague and analyzed ... | 2010 | 20158333 |
| lung antioxidant and cytokine responses to coarse and fine particulate matter from the great california wildfires of 2008. | the authors have previously demonstrated that wildfire-derived coarse or fine particulate matter (pm) intratracheally instilled into lungs of mice induce a strong inflammatory response. in the current study, the authors demonstrate that wildfire pm simultaneously cause major increases in oxidative stress in the mouse lungs as measured by decreased antioxidant content of the lung lavage supernatant fluid 6 and 24 h after pm administration. concentrations of neutrophil chemokines/cytokines and of ... | 2010 | 20388000 |
| transmission cycles of borrelia burgdorferi and b. bissettii in relation to habitat type in northwestern california. | this study was undertaken to determine which rodent species serve as primary reservoirs for the lyme disease spirochete borrelia burgdorferi in commonly occurring woodland types in inland areas of northwestern california, and to examine whether chaparral or grassland serve as source habitats for dispersal of b. burgdorferi- or b. bissettii-infected rodents into adjacent woodlands. the western gray squirrel (sciurus griseus) was commonly infected with b. burgdorferi in oak woodlands, whereas exam ... | 2009 | 20514140 |
| cranial shape varies along an elevation gradient in gambel's white-footed mouse (peromyscus maniculatus gambelii) in the grinnell resurvey yosemite transect. | environmental variation over a species's range creates differing pressures to which organisms must adjust in order to survive. taxa can respond to these pressures at population and individual levels, leading to localized phenotypic differentiation. assessing the spatial distribution of phenotypic variation can illuminate how dramatically varying environmental factors shape phenotypes and may forecast a taxon's ability to adapt should conditions change. we characterized morphological variation al ... | 2010 | 20623653 |
| effects of an invasive forest pathogen on abundance of ticks and their vertebrate hosts in a california lyme disease focus. | invasive species, including pathogens, can have important effects on local ecosystems, including indirect consequences on native species. this study focuses on the effects of an invasive plant pathogen on a vertebrate community and ixodes pacificus, the vector of the lyme disease pathogen (borrelia burgdorferi) in california. phytophthora ramorum, the causative agent of sudden oak death, is a non-native pathogen killing trees in california and oregon. we conducted a multi-year study using a grad ... | 2010 | 20941513 |
| cxcl5 plasma levels decrease in patients with chronic liver disease. | cxcl5 (chemokine [c-x-c motif] ligand 5, also known as epithelial neutrophil-activating peptide 78 [ena78]) belongs to the cxc chemokine family and has been shown to have promitotic effects on hepatocytes. the aim of our study was to assess cxcl5 plasma levels in patients with chronic liver disease. | 2011 | 21332547 |
| barrels xxiii: barrels by the shore. | the 23rd annual barrels meeting was held on the university of california, san diego campus and highlighted the latest advances in the whisker-to-barrel pathway and beyond. the annual meeting brought together investigators from a dozen countries to present their data in posters and short talks. the meeting focused on several themes, first the barrel system was used as a model to study the consequences that result from alterations in the normal pattern(s) of development. a second session focused o ... | 2011 | 21500988 |
| genetic impacts of anacapa deer mice reintroductions following rat eradication. | the anacapa deer mouse is an endemic subspecies that inhabits anacapa island, part of channel islands national park, california. we used mitochondrial dna cytochrome c oxidase subunit ii gene (coii) and 10 microsatellite loci to evaluate the levels of genetic differentiation and variation in ôê+1400 anacapa deer mice sampled before and for 4ôçâyears after a black rat (rattus rattus) eradication campaign that included trapping, captive holding and reintroduction of deer mice. both mitochondrial a ... | 2011 | 21711403 |
| phase i/ii clinical trial of 2-difluoromethyl-ornithine (dfmo) and a novel polyamine transport inhibitor (mqt 1426) for feline oral squamous cell carcinoma. | polyamines are essential for cell proliferation. their production is dysregulated in many cancers and polyamine depletion leads to tumour regression in mouse models of squamous cell carcinoma (scc). the purpose of this study was to determine the maximally tolerated dose of the polyamine transport inhibitor, mqt 1426, when combined with the ornithine decarboxylase (odc) inhibitor, dfmo, and to determine whether this therapy results in reduction in tumour polyamine levels. thirteen cats with oral ... | 2011 | 22077408 |
| Researcher who linked chronic fatigue syndrome to mouse virus is arrested. | | 2011 | 22108469 |
| activity of ultra-low doses of antibodies to gamma-interferon against lethal influenza a(h1n1)2009 virus infection in mice. | background: the influenza a virus is a highly infective agent that causes acute pulmonary diseases. in serious cases, it causes pneumonia which is particularly fatal in patients with cardiopulmonary diseases, obesity, young children and elderly people. the present study shows a protective effect of ultra-low doses of purified antibodies to gamma-interferon (anaferon for children®, ac®) against lethal influenza virus infection caused by pandemic influenza virus a(h1n1) in mice. methods: balb/c mi ... | 2011 | 22178245 |
| The fecal viral flora of wild rodents. | The frequent interactions of rodents with humans make them a common source of zoonotic infections. To obtain an initial unbiased measure of the viral diversity in the enteric tract of wild rodents we sequenced partially purified, randomly amplified viral RNA and DNA in the feces of 105 wild rodents (mouse, vole, and rat) collected in California and Virginia. We identified in decreasing frequency sequences related to the mammalian viruses families Circoviridae, Picobirnaviridae, Picornaviridae, A ... | 2011 | 21909269 |
| a knockout mouse resource for the biomedical research community. | the knockout mouse project (komp) repository archives and distributes vectors, embryonic stem cell clones, frozen germplasm, and live mutant mice for 8,500 knockout genes. here, we describe the creation and functions of the komp repository. | 2011 | 22211970 |