Publications

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isolation of dengue viruses in mosquito cell cultures under field conditions. 197874531
arboviruses in the caribbean islands. 19684886890
dengue type 3 virus isolated from an antiguan patient during the 1963-64 caribbean epidemic. 19694978599
comparison of dengue-2 and dengue-3 virus strains by neutralization tests and identification of a subtype of dengue-3. 19725061690
observations related to the pathogenesis of dengue hemorrhagic fever. ii. antigenic and biologic properties of dengue viruses and their association with disease response in the host. 19705464392
natural transovarial transmission of dengue 4 virus in aedes aegypti in trinidad.the isolation of dengue 4 virus from adult aedes aegypti, reared from eggs collected in nature, is reported for the first time. from the locality where the isolate was made, 25 pools consisting of 1,848 ae. aegypti reared from eggs were processed. in this study, 10 different localities were sampled and a total of 10,957 ae. aegypti adults, collected as eggs or larvae in nature, were processed for virus isolation. from a total of 158 mosquito pools tested, one recovery of dengue 4 virus was made. ...19846542323
congenital yellow fever virus infection after immunization in pregnancy.to determine whether yellow fever (yf) vaccine administered in pregnancy causes fetal infection, women who were vaccinated during unrecognized pregnancy in a mass campaign in trinidad were studied retrospectively. maternal and cord or infant blood were tested for igm and neutralizing antibodies to yf and dengue viruses. one of 41 infants had igm and elevated neutralizing antibodies to yf virus, indicating congenital infection. the infant, the first reported case of yf virus infection after immun ...19938245539
dengue haemorrhagic fever/dengue shock syndrome. an unwelcome arrival in trinidad.this is the first report of dengue haemorrhagic fever and dengue shock syndrome in trinidad. dengue infection was confirmed serologically or by viral isolation in five patients, aged 15 to 53 years, who presented with fever, thrombocytopenia and haemoconcentration. three patients developed dengue shock syndrome, which was fatal; although there was no haemorrhagic tendency among these patients, bleeding occurred shortly before death in one of them. two patients who had dengue haemorrhagic fever s ...19979260532
transmission thresholds for dengue in terms of aedes aegypti pupae per person with discussion of their utility in source reduction efforts.the expense and ineffectiveness of drift-based insecticide aerosols to control dengue epidemics has led to suppression strategies based on eliminating larval breeding sites. with the notable but short-lived exceptions of cuba and singapore, these source reduction efforts have met with little documented success; failure has chiefly been attributed to inadequate participation of the communities involved. the present work attempts to estimate transmission thresholds for dengue based on an easily-de ...200010761719
surveillance for the dengue vector aedes aegypti in tobago, west indies.an island-wide house survey was conducted in january 2002 to determine the geographic distribution, container profile, and population density of the aedes aegypti in tobago, west indies. the results showed the ae. aegypti infestation levels were significantly different (p > 0.01) among the 4 districts, with greater infestation levels (p > 0.01) observed in the northern and windward districts than in the central and leeward districts. from the 50 towns in tobago, houses were found positive in del ...200314524540
seroprevalence of dengue in trinidad using rapid test kits: a cord blood survey.a cross-sectional sero-epidemiological study was conducted to determine the prevalence of dengue in trinidad. two commercial rapid test kits, panbio dengue duo igm and igg rapid strip test and the bio-check plus dengue g/m cassette test (brittney) were used. the immunosorbent assay (elisa) (focus technologies, california) was used as the control. one hundred and twenty five cord blood samples were collected (46 from mt. hope women's hospital (mh) and 79 from the san fernando general hospital (sf ...200717303060
improved serotype-specific dengue virus detection in trinidad and tobago using a multiplex, real-time rt-pcr.dengue virus (denv) transmission occurs throughout the caribbean, though laboratory confirmation and epidemiologic surveillance are limited by the availability of serotype-specific molecular diagnostics. in this study, we show that a serotype-specific denv multiplex, real-time reverse transcriptase-pcr (rt-pcr) detected denv rna in significantly more samples (82/182) than a reference hemi-nested rt-pcr (57/182; p=0.01).201425533614
dengue hemorrhagic fever in trinidad and tobago: a case for a conservative approach to platelet transfusion.dengue fever is endemic to trinidad and tobago. a retrospective analysis of all adult admissions at a tertiary hospital in trinidad treated for dengue during january 1-december 31, 2008 was performed. a total of 186 patients were treated during this period: 98.9% (184) of the patients were thrombocytopenic; 45.2% were severely thrombocytopenic; 13 patients showed development of minor hemorrhage and only one case of major hemorrhage; platelet transfusion was given for 7% (13) of the cases; and 6 ...022403331
molecular characterisation of chikungunya virus infections in trinidad and comparison of clinical and laboratory features with dengue and other acute febrile cases.local transmission of chikungunya virus (chikv) was first documented in trinidad and tobago (t&t) in july 2014 preceding a large epidemic. at initial presentation, it is difficult to distinguish chikungunya fever (chikf) from other acute undifferentiated febrile illnesses (aufis), including life-threatening dengue disease. we characterised and compared dengue virus (denv) and chikv infections in 158 patients presenting with suspected dengue fever (df) and chikf at a major hospital in t&t, and pe ...201526580074
dengue in costa rica: the gap in local scientific research. 017316494
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