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virulence attributes of helicobacter pylori isolates & their association with gastroduodenal disease.background & objectives : certain genotype(s) of helicobacter pylori strains may play important role in the development of gastric cancer (gc) and peptic ulcer disease (pud). this study was undertaken to investigate the association of caga, caga3 / region subtypes, baba2 and vaca genotypes of h. pylori with gc, pud and non-ulcer dyspepsia (nud) as there are no such studies from india. methods : a total of 348 consecutive adult patients (nud 241, pud 45, gc 62) undergoing upper gastrointestinal e ...201121623037
diversity in the cag pathogenicity island of helicobacter pylori isolates in populations from north and south india.the cag pathogenicity island (cagpai) has been reported to be the major virulence determinant in helicobacter pylori-related diseases. in the present study, the diversity of the caga gene and the integrity of the cagpai in 158 h. pylori strains from varanasi (north india) and hyderabad (south india) were studied by amplifying the caga gene (approximately 3.5 kb), followed by pcr-rflp analysis. the results revealed significant differences in the caga gene and the integrity of the cagpai between n ...201019815664
helicobacter pylori and pathogenesis of gallbladder cancer.gallbladder cancer (gbc) is a rare but leading cause of cancer-related deaths worldwide. the incidence of gbc is increasing at an alarming rate in the varanasi region, and its etiology remains obscure.201121261714
geographical difference in antimicrobial resistance pattern of helicobacter pylori clinical isolates from indian patients: multicentric study.to assess the pattern of antimicrobial resistance of helicobacter pylori isolates from peptic ulcer disease patients of chandigarh, delhi, lucknow, hyderabad and chennai in india, and to recommend an updated anti-h. pylori treatment regimen to be used in these areas.200314675265
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