Publications

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helicobacter pylori infection in the colombian andes: a population-based study of transmission pathways.in 1992, the authors studied helicobacter pylori infection and exposures relevant to person-to-person, waterborne, foodborne, and zoonotic transmission in a census sample of 684 2-9-year-old children in aldana, nariño, a rural community in the colombian andes. h. pylori prevalence, as determined by the 13c-urea breath test, was 69%, and prevalence increased from 53% in 2 year-olds to 87% in 9 year-olds. beginning at 3 years of age, a higher percentage of males compared with females were infected ...19968686698
virulence-associated genotypes of helicobacter pylori: do they explain the african enigma?the aim of this study was to compare the distribution of virulence-associated genotypes of helicobacter pylori in two colombian populations with contrasting gastric cancer risk but with similar h. pylori infection prevalence.200212425557
intestinal helminthiasis in colombian children promotes a th2 response to helicobacter pylori: possible implications for gastric carcinogenesis.colombians living in coastal tumaco have a lower incidence of helicobacter pylori-associated gastric cancer compared with residents of pasto in the high andes. considering the risk for h. pylori disease seems affected by features of bacterial virulence and host polymorphisms, other poorly understood influences, such as concurrent helminthiasis, may also be important.200515941957
a randomized clinical trial to determine the efficacy of regimens containing clarithromycin, metronidazole, and amoxicillin among histologic subgroups for helicobacter pylori eradication in a developing country.most treatments deemed effective for helicobacter pylori eradication in developed countries are less effective in developing countries. regimens containing clarithromycin, metronidazole, and amoxicillin seem efficacious despite antibiotic resistance, and may be a viable option in developing countries.200919298337
age at acquisition of helicobacter pylori infection: comparison of two areas with contrasting risk of gastric cancer.helicobacter pylori infection is usually acquired during childhood and is a known risk factor for the development of gastric malignancies in adulthood. it has been reported that early age at first infection may determine a neoplastic outcome in adults. the purpose of this study was to determine the prevalence of helicobacter pylori infection in children residing in areas with high (pasto) and low risk (tumaco) of gastric cancer in colombia to evaluate whether differences in the age of acquisitio ...200415165263
histopathology of gastritis in helicobacter pylori-infected children from populations at high and low gastric cancer risk.infection with helicobacter pylori has been recognized as a cause of gastric carcinoma. although the neoplasia is always detected in adults, the infection starts in childhood. it has been reported that early age at first infection is a determinant of gastric cancer risk. in this study, we examined the histopathology of the gastric mucosa in infected children from a population at high risk for gastric cancer (pasto, colombia) and compared it with that of a lower-risk population (new orleans, la). ...200312673553
lewis, secretor, and abo phenotypes, and sulfomucin expression in gastric intestinal metaplasia.the closely interrelated lewis, secretor, and abo phenotypes have long been linked to the risk of peptic ulcers and gastric cancer and may modulate the interaction between helicobacter pylori and the gastric surface epithelium. we explored the association between the expression of sulfomucins in gastric intestinal metaplasia, a known marker of preneoplastic progression, and the expression of lewis, secretor, and abo phenotypes, in 523 subjects from nariño, colombia, and 856 subjects from norther ...19979107434
helicobacter pylori and gastric carcinoma. serum antibody prevalence in populations with contrasting cancer risks.this investigation examined the correlation between helicobacter pylori (hp) infection, as reflected in immunoglobulin g serum antibodies, and the risk of gastric cancer. serum samples were obtained from populations with contrasting gastric cancer risks. the highest prevalence of hp infection, 93%, was observed in the adult population at highest gastric cancer risk, the residents of pasto, colombia. in the lower risk colombian city of cali, a 63% overall prevalence rate was found. both children ...19902249197
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