Publications

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development of colombian isolates of leishmania (viannia) panamensis, le. (v.) guyanensis and le. (v.) braziliensis in the sandfly lutzomyia intermedia (lutz & neiva, 1912) under experimental conditions.the development of colombian leishmania species of the subgenus viannia in lutzomyia intermedia was similar to that observed with brazilian le. (v.) braziliensis: colonization of the pylorus by paramastigotes; promastigotes in the midgut and massive infection of stomodeal valve. difference was observed in the number of paramastigotes colonizing the pylorus, which was smaller in colombian leishmania species than brazilian le. braziliensis.19938139462
immunoblot analysis of leishmania panamensis antigens in sera of patients with american cutaneous leishmaniasis.sera from 86 colombian patients with parasitologically confirmed cutaneous leishmaniasis were studied by immunoblot analysis in order to identify a specific pattern for leishmania infection. a soluble extract of leishmania panamensis was used as the antigen. sera from patients with chagas' disease and sera from patients with no record of infection with trypanosomatids were also studied. the sera from patients with cutaneous leishmaniasis specifically recognized fractions of 120 kda (76.7%), 123 ...19979399491
intraspecific heterogeneity in the mini-exon gene localization of leishmania (viannia) panamensis and leishmania (viannia) guyanensis from colombia.intraspecific heterogeneity was demonstrated in the mini-exon gene localization from leishmania (viannia) panamensis and l. (viannia) guyanensis. different karyotypes were detected in human isolates circulating in endemic areas of colombia. the presence of mini-exon gene sequences on chromosomes of different sizes, ranging from 370 to 800 kb in l. (v.) panamensis and from 500 to 800 kb in l. (v.) guyanensis, was observed and was neither strain nor species specific. in some cases, hybridization w ...200011191900
susceptibility of spiny rats (proechimys semispinosus) to leishmania (viannia) panamensis and leishmania (leishmania) chagasi.the role of proechimys semispinosus as reservoir of leishmania (viannia) panamensis on the colombian pacific coast was experimentally evaluated. the susceptibility to l. chagasi also was assessed to determine the utility of this rodent as a model for studying reservoir characteristics in the laboratory. wild-caught animals were screened for natural trypanosomatid infections, and negative individuals were inoculated intradermally (id) in the snout or feet with 10(7) promastigotes of l. panamensis ...200212386716
noninferiority of miltefosine versus meglumine antimoniate for cutaneous leishmaniasis in children.background. children have a lower response rate to antimonial drugs and higher elimination rate of antimony (sb) than adults. oral miltefosine has not been evaluated for pediatric cutaneous leishmaniasis. methods. a randomized, noninferiority clinical trial with masked evaluation was conducted at 3 locations in colombia where leishmania panamensis and leishmania guyanensis predominated. one hundred sixteen children aged 2-12 years with parasitologically confirmed cutaneous leishmaniasis were ran ...201222238470
cd4 t cell activation by b cells in human leishmania (viannia) infection.an effective adaptive immune response requires activation of specific cd4 t cells. the capacity of b cells to activate cd4 t cells in human cutaneous leishmaniasis caused by leishmania (viannia) has not been evaluated.201424568275
an epidemic outbreak of canine cutaneous leishmaniasis in colombia caused by leishmania braziliensis and leishmania panamensis.the largest recorded outbreak of cutaneous leishmaniasis in colombia's history occurred during 2005-2009 in soldiers of the colombian army, with ~40,000 cases. this outbreak was caused by the influx of military personnel into the jungle with the mission of combat illicit crops and the guerrilla. the soldiers remain for long periods within the rainforest and are exposed to the bite of infected sand flies. during the military activities, soldiers work with dogs specially trained to detect landmine ...022556078
coumarins from galipea panamensis and their activity against leishmania panamensis.two new coumarin compounds (1 and 2), phebalosin (3), its derived artifact murralongin (4), and murrangatin acetonide (5) were isolated from the leaves of galipea panamensis. the structures of 1 and 2 were assigned as 7-{[(2r*)-3,3-dimethyloxiran-2-yl]methoxy}-8-[(2r*,3r*)-3-isopropenyloxiran-2-yl]-2h-chromen-2-one and 7-methoxy-8-(4-methyl-3-furyl)-2h-chromen-2-one, respectively, on the basis of their spectroscopic data (primarily nmr and ms). compounds 1-3 were tested against axenic amastigote ...201020423106
mucosal leishmaniasis due to leishmania (viannia) panamensis in colombia: clinical characteristics.the leishmaniases are a group of diseases whose clinical presentation is in part determined by the infecting species. until recently, mucosal leishmaniasis was attributed exclusively to leishmania (viannia) braziliensis; however, the capacity of other species of the subgenus viannia to invade mucosal tissue has been documented. this report examines the clinical characteristics of 23 parasitologically diagnosed patients with mucosal leishmaniasis due to l. (v.) panamensis from the pacific coast o ...19989684627
epidemiology of cutaneous leishmaniasis in colombia: environmental and behavioral risk factors for infection, clinical manifestations, and pathogenicity.through a longitudinal, active surveillance for leishmania (viannia) braziliensis and leishmania (viannia) panamensis infection and lesions on the pacific coast of colombia, risk factors for infection (leishmanin skin test conversion), leishmanial lesions, and pathogenicity were examined. risk factor information was obtained prior to and independently of case ascertainment. similar factors were associated with acquisition of infection and of leishmaniasis, including male sex, age > 10 years, and ...19938354913
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