| susceptibility of macaca fascicularis monkeys from mauritius to different species of plasmodium. | macaca fascicularis monkeys from mauritius were shown to be susceptible via sporozoite inoculation to 7 species of plasmodium (p. fragile, p. coatneyi, p. gonderi, p. inui, p. cynomolgi, p. knowlesi, and p. fieldi), indigenous to macaques in southeastern asia. four monkeys were sequentially infected with different species of plasmodium to determine maximum and course of parasitemia. in 2 nonsplenectomized monkeys, p. fragile developed maximum parasite counts of only 134 and 155/microliters. for ... | 1992 | 1597796 |
| mitochondrial dna of the mauritian macaques (macaca fascicularis): an example of the founder effect. | macaque monkeys (macaca fascicularis) were introduced to the island of mauritius approximately 400 years ago. this study compares the mitochondrial dna of macaques on mauritius with those from indonesia and the philippines. the goal is to measure the amount of evolutionary change that has occurred in this isolated population over 400 years, and to address questions regarding the origin of the mauritian founders. amplification of the control region of the mitochondrial genome via the polymerase c ... | 1995 | 7755104 |
| tuberculosis in imported nonhuman primates--united states, june 1990-may 1993. | nonhuman primates (nhps) shipped to the united states must be quarantined and monitored for evidence of infectious diseases transmissible to humans. during may-october 1992, cdc investigated reports from nhp importers of mycobacterial infections in nhps recently imported from mauritius. this report describes a review of tuberculosis (tb) in all 249 imported shipments of cdc-permitted nhp species in the united states from june 1990 through may 1993 and updates recommendations regarding the identi ... | 1993 | 8332115 |
| the origin of cynomolgus monkey affects the outcome of kidney allografts under neoral immunosuppression. | | 2002 | 12431645 |
| aeromonas simiae sp. nov., isolated from monkey faeces. | two aeromonas strains, ibs s6874(t) and ibs s6652, were isolated from the faeces of two healthy monkeys (macaca fascicularis) from mauritius that were kept in quarantine in the centre for primatology, strasbourg, france. phylogenetic analysis based on 16s rrna gene sequences showed that the two isolates formed an unknown genetic lineage within the genus aeromonas. the two isolates had nearly identical sequences (0.1 % nucleotide substitution) that were related closely to those of recognized aero ... | 2004 | 15023964 |
| expression of human il-1alpha after intramarrow gene transfer into healthy non-human primate by adenoviral vector. | interleukin-1alpha (il-1alpha) is a multifunctional cytokine that stimulates myelopoiesis in macaque. however, daily systemic injections of il-1alpha are associated with severe side effects. we therefore investigated the feasibility of a gene therapy strategy aimed at increasing the il-1alpha local production in bone marrow with limited release of the vector into the blood circulation. intra-medullar administration of adenoviral vector containing human il-1alpha (huil-1alpha) gene resulted in en ... | 2005 | 15667338 |
| unusually high frequency mhc class i alleles in mauritian origin cynomolgus macaques. | acute shortages of indian origin rhesus macaques significantly hinder hiv/aids research. cellular immune responses are particularly difficult to study because only a subset of animals possess mhc class i (mhc i) alleles with defined peptide-binding specificities. to expand the pool of nonhuman primates suitable for studies of cellular immunity, we defined 66 mhc i alleles in cynomolgus macaques (macaca fascicularis) of chinese, vietnamese, and mauritian origin. most mhc i alleles were found only ... | 2005 | 16210628 |
| simian immunodeficiency virus sivmac239 infection of major histocompatibility complex-identical cynomolgus macaques from mauritius. | nonhuman primates are widely used to study correlates of protective immunity in aids research. successful cellular immune responses have been difficult to identify because heterogeneity within macaque major histocompatibility complex (mhc) genes results in quantitative and qualitative differences in immune responses. here we use microsatellite analysis to show that simian immunodeficiency virus (siv)-susceptible cynomolgus macaques (macaca fascicularis) from the indian ocean island of mauritius ... | 2007 | 17035320 |
| seroprevalence of sv40-like polyomavirus infections in captive and free-ranging macaque species. | to investigate the seroprevalence of polyomavirus infections in macaques, we analyzed 1579 sera from nine different species for antibodies cross-reactive with simian virus 40 (sv40) in an enzyme-linked immunosorbent assay. most samples were collected from captive animals, but we also investigated a colony of free-ranging barbary macaques (macaca sylvanus). | 2008 | 18194222 |
| genetic diversity of longtail macaques (macaca fascicularis) on the island of mauritius: an assessment of nuclear and mitochondrial dna polymorphisms. | individuals from an introduced population of longtail macaques on mauritius have been extensively used in recent research. this population has low mhc gene diversity, and is thus regarded as a valuable resource for research. | 2008 | 18199072 |
| origin and number of founders in an introduced insular primate: estimation from nuclear genetic data. | cynomolgus macaques (macaca fascicularis) were introduced on the island of mauritius between 400 and 500 years ago and underwent a strong population expansion after a probable initial founding event. however, in practice, little is known of the geographical origin of the individuals that colonized the island, on how many individuals were introduced, and of whether the following demographic expansion erased any signal of this putative bottleneck. in this study, we asked whether the current nuclea ... | 2008 | 18261045 |
| mitochondrial dna sequence phylogeny of 4 populations of the widely distributed cynomolgus macaque (macaca fascicularis fascicularis). | we studied the mitochondrial dna (mtdna) polymorphism of 304 macaca fascicularis fascicularis (m. f. fascicularis) individuals, representative of 4 cynomolgus macaque populations (indochina, indonesia, philippines, and mauritius). by sequencing a 590-bp fragment in the hypervariable ii region of the d-loop region, we defined 70 haplotypes. the homologous region was also characterized in 22 chinese macaca mulatta and 2 macaca sylvanus. the phylogenetic analysis confirms the monophyly of m. f. fas ... | 2008 | 18334507 |
| mhc haplotype frequencies in a uk breeding colony of mauritian cynomolgus macaques mirror those found in a distinct population from the same geographic origin. | mauritian cynomolgus macaques have greatly restricted genetic diversity in the mhc region compared to other non-human primates; however, the frequency of common mhc haplotypes among captive-bred populations has not been reported. | 2009 | 19018947 |
| hematology and serum chemistry parameters in juvenile cynomolgus monkeys (macaca fascicularis) of mauritius origin: comparison between purpose-bred and captured animals. | the vast majority of non-human primates used for experimental activities are purpose-bred. however, in case of particular procedures or specific projects, it may still be necessary to use animals captured in the wild. | 2009 | 19236562 |
| study of cynomolgus monkey (macaca fascicularis) dra polymorphism in four populations. | to describe the polymorphism of the dra gene in macaca fascicularis, we have studied 141 animals either at cdna level (78 animals from mauritius, the philippines, and vietnam) or genomic level (63 animals from the philippines, indonesia, and vietnam). in total, we characterized 22 cdna dra alleles, 13 of which had not been described until now. in the mauritius population, we confirmed the presence of three dra alleles. in the philippine and vietnam populations, we observed 11 and 14 dra alleles, ... | 2010 | 20094710 |
| spontaneous findings in the heart of mauritian-origin cynomolgus macaques (macaca fascicularis). | the cynomolgus macaque is the most commonly used nonhuman primate in nonclinical toxicity testing, but the impact of the geographic source of cynomolgus macaque on differences in spontaneous pathology and response to xenobiotics has only recently been explored. previous work from the authors' facility has described spontaneous cardiac findings in predominantly indonesian-source animals; however, the authors have recently observed a novel spectrum of cardiac findings in mauritian-source animals. ... | 2010 | 20124493 |
| mhc heterozygote advantage in simian immunodeficiency virus-infected mauritian cynomolgus macaques. | the importance of a broad cd8 t lymphocyte (cd8-tl) immune response to hiv is unknown. ex vivo measurements of immunological activity directed at a limited number of defined epitopes provide an incomplete portrait of the actual immune response. we examined viral loads in simian immunodeficiency virus (siv)-infected major histocompatibility complex (mhc)-homozygous and mhc-heterozygous mauritian cynomolgus macaques. chronic viremia in mhc-homozygous macaques was 80 times that in mhc-heterozygous ... | 2010 | 20375000 |
| mhc haplotype m3 is associated with early control of shivsbg infection in mauritian cynomolgus macaques. | the restricted major histocompatibilty complex of mauritian cynomolgus macaques confers exceptional potential on this species in human immunodeficiency virus (hiv) vaccine development. however, knowledge of the effects of mhc genetics on commonly used simian immunodeficiency virus (siv) and simian/human immunodeficiency virus (shiv) stocks is incomplete. we determined the effect of mhc haplotypes on shivsbg replication kinetics in a cohort of 25 naïve cynomolgus macaques. haplotype m3 was associ ... | 2010 | 20403147 |
| variable prevalence and functional diversity of the antiretroviral restriction factor trimcyp in macaca fascicularis. | the retroviral restriction factor trimcyp, derived from the trim5 gene, blocks replication at a post-entry step. trimcyp has so far been found in four species of asian macaques, macaca fascicularis, m. mulatta, m. nemestrina, and m. leonina. m. fascicularis is commonly used as a model for aids research, but trimcyp has not been analyzed in detail in this species. we analyzed the prevalence of trimcyp in samples from indonesia, indochina, the philippines, and mauritius. we found that trimcyp is p ... | 2011 | 21795330 |
| Diversity of TRIM5a and TRIMCyp sequences in cynomolgus macaques from different geographical origins. | The TRIM5a restriction factor can protect some species of monkeys, but not humans, from HIV infection. It has also emerged that some monkeys have a cyclophilin A domain retrotransposed into the TRIM5 locus resulting in the expression of a TRIMCyp protein with anti-retroviral activity. A high degree of sequence variation in the primate TRIM5 gene has been reported that varies between populations of rhesus macaques, a widely used non-human primate model of HIV/AIDS, and recently shown to correlate ... | 2011 | 22124667 |
| early potent protection against heterologous sivsme660 challenge following live attenuated siv vaccination in mauritian cynomolgus macaques. | live attenuated simian immunodeficiency virus (siv) vaccines represent the most effective means of vaccinating macaques against pathogenic siv challenge. however, thus far, protection has been demonstrated to be more effective against homologous than heterologous strains. immune correlates of vaccine-induced protection have also been difficult to identify, particularly those measurable in the peripheral circulation. | 2011 | 21853072 |
| condylomatous genital lesions in cynomolgus macaques from mauritius. | genital condyloma-like lesions were observed on male and female cynomolgus macaque monkeys (macaca fascicularis) originating from the island of mauritius. cytobrush and/or biopsy samples were obtained from lesions of 57 affected macaques. primary histologic features included eosinophilic, neutrophilic, and lymphoplasmacytic penile and vulvar inflammation, epidermal hyperplasia with acanthosis, and increased collagenous stroma. polymerase chain reaction-based assays to amplify viral dna revealed ... | 2012 | 23262641 |
| chikungunya antibodies detected in non-human primates and rats in three indian ocean islands after the 2006 chikv outbreak. | the role of terrestrial vertebrates in the epidemiology of chikungunya disease is poorly understood. we evaluated their exposure and amplification role during the 2006 chikungunya outbreak in the indian ocean. blood samples were collected from 18 mammalian and reptile species from reunion island, mauritius and mayotte. among the 1051 samples serologically tested for chikungunya virus (chikv), two crab-eating macaques (macaca fascicularis) and two ship rats (rattus rattus) proved to be exposed to ... | 2014 | 24885529 |
| assessment and improvement of indian-origin rhesus macaque and mauritian-origin cynomolgus macaque genome annotations using deep transcriptome sequencing data. | the genome annotations of rhesus (macaca mulatta) and cynomolgus (macaca fascicularis) macaques, two of the most common non-human primate animal models, are limited. | 2014 | 24810475 |
| discovery of naturally occurring transmissible chronic hepatitis b virus infection among macaca fascicularis from mauritius island. | despite a high prevalence of hepatitis b virus (hbv) infection in endangered apes, no hbv infection has been reported in small, old-world monkeys. in search for a small, nonhuman primate model, we investigated the prevalence of hbv infection in 260 macaque (cercopithecidae) sera of various geographical origins (i.e., morocco, mauritius island, and asia). hbv-positive markers were detected in cynomolgus macaques (macaca fascicularis) from mauritius island only, and, remarkably, hbv dna was positi ... | 2013 | 23536484 |
| specific cd8+ t cell responses correlate with control of simian immunodeficiency virus replication in mauritian cynomolgus macaques. | specific major histocompatibility complex (mhc) class i alleles are associated with an increased frequency of spontaneous control of human and simian immunodeficiency viruses (hiv and siv). the mechanism of control is thought to involve mhc class i-restricted cd8(+) t cells, but it is not clear whether particular cd8(+) t cell responses or a broad repertoire of epitope-specific cd8(+) t cell populations (termed t cell breadth) are principally responsible for mediating immunologic control. to tes ... | 2012 | 22573864 |
| mauritian cynomolgus macaques with m3m4 mhc genotype control sivmac251 infection. | understanding natural hiv control may lead to new preventative or therapeutic strategies. several protective major histocompatibility complex (mhc) genotypes were found in humans and rhesus macaques. here, we report a simian immunodeficiency virus (siv) controller mhc genotype in mauritian cynomolgus macaques (mcms). | 2017 | 28748659 |
| reference intervals for biochemical and haematological analytes of juvenile captive-bred long-tailed macaques (macaca fascicularis) from mauritius with examination of the effects of individual characteristics using principal component analysis. | the mauritian cynomolgus macaque (macaca fascicularis) is widely used in biomedical research. determining reference intervals for biochemical and haematological analytes provides an important tool for clinical diagnosis and pre-clinical research. | 2016 | 27506181 |
| factors influencing reproduction in captive-bred cynomolgus monkeys (macaca fascicularis) from mauritius. | the cynomolgus monkey is widely used in reproductive research. however, the effects on their reproductive parameters of infant and maternal factors such as birth order, sex of infants, twin births, maternal age and lactation status have not been fully examined. the aim of this retrospective study was to determine how such infant and maternal factors impact on infant birth weight, birth viability, neonatal loss and retained placenta in cynomolgus monkeys. the study was based on birth data from a ... | 2015 | 26375598 |
| comparison of physiologic and pharmacologic parameters in asian and mauritius cynomolgus macaques. | this comparative study was conducted to assess background physiologic and pharmacologic parameters of cynomolgus macaques (macaca fascicularis) from cambodia, from a mixed asian source (cambodia, vietnam and indonesia), and from mauritius. this evaluation provides a comprehensive assessment of several of these parameters in a single study. ten male and 10 female captive-bred, age-matched macaques from each source were evaluated. criteria for evaluation included weight gain, assessment of drug me ... | 2015 | 26111605 |
| analysis of full-length mitochondrial dna d-loop sequences from macaca fascicularis of different geographical origin reveals novel haplotypes. | cynomolgus macaques are indigenous to asia occupying a range of geographical areas. a non-indigenous population established on mauritius approximately 500 years ago. mauritian cynomolgus macaques are recognised as having low genetic diversity compared to indonesian macaques, from which they originated. as cynomolgus macaques are widely used as a biomedical model, there have been many studies of their genetic relationships. however, population diversity and relationships have only been assessed t ... | 2015 | 25707924 |
| genetic substructure in cynomolgus macaques (macaca fascicularis) on the island of mauritius. | nonhuman primates are commonly used in biomedical research as animal models of human disease and behavior. compared to common rodent models, nonhuman primates are genetically, physiologically, behaviorally and neurologically more similar to humans owing to more recent shared ancestry and therefore provide the advantage of greater translational validity in preclinical studies. the cynomolgus macaque (macaca fascicularis) is one of the most commonly used nonhuman primates in academic and industry ... | 2014 | 25174998 |
| the genetic composition of populations of cynomolgus macaques (macaca fascicularis) used in biomedical research. | the genetic composition of cynomolgus macaques used in biomedical research is not as well-characterized as that of rhesus macaques. | 2013 | 23480663 |
| population and landscape genetics of an introduced species (m. fascicularis) on the island of mauritius. | the cynomolgus macaque, macaca fascicularis, was introduced onto the island of mauritius in the early 17(th) century. the species experienced explosive population growth, and currently exists at high population densities. anecdotes collected from nonhuman primate trappers on the island of mauritius allege that animals from the northern portion of the island are larger in body size than and superior in condition to their conspecifics in the south. although previous genetic studies have reported m ... | 2013 | 23341917 |
| identification of 23 novel mhc class i alleles in cynomolgus macaques of philippine and philippine/mauritius origins. | we report here novel mafa-a, -ag and -b alleles identified in two groups of cynomolgus macaques. | 2012 | 22236321 |