| insights into the molecular evolution of dengue virus type 4 in puerto rico over two decades of emergence. | dengue has emerged globally as a major human health problem since the 1950s and is now the most important arboviral disease of humans, infecting nearly 400 million people annually. while some cases are asymptomatic, others can develop a febrile illness (dengue fever) or even progress to severe and fatal dengue. dengue is caused by any of 4 closely related but distinct viruses, known as dengue virus serotype 1 to 4 (denv-1 to denv-4) which are maintained in endemic transmission to humans in large ... | 2016 | 26569594 |