alveolar hydatid disease in minnesota. first human case acquired in the contiguous united states.a 56-year-old woman from southwestern minnesota underwent an extended left hepatic lobectomy to remove a large multinodular mass with a necrotic central cavity. the clinical, serological, and pathological findings led to the diagnosis of alveolar hydatid disease, and specific identification of echinococcus multilocularis was achieved by growing mature larvas in voles inoculated intraperitoneally with tissue from the hepatic lesions. the patient probably acquired her infection some years previous ...1979762867
parasiticidal effect of chemotherapy in alveolar hydatid disease: review of experience with mebendazole and albendazole in alaskan eskimos.evidence that the larval stage of echinococcus multilocularis in humans is killed by chemotherapy is presented in a review of our 17-year experience with treatment of alveolar hydatid disease in alaska. the efficacy of chemotherapy was assessed with use of an in vivo assay of parasite viability by means of inoculation of voles, immunohistochemical tests, and histopathologic findings. of 14 tests performed for nine patients, 12 in vivo assays (86%) were negative after chemotherapy, while only two ...19921520758
comparison of montana and alaska isolates of echinococcus multilocularis in gerbils with observations on the cyst growth, hook characteristics, and host assess its biological distinctness, an isolate of echinococcus multilocularis from montana was compared with an isolate from alaska in gerbils (meriones unguiculatus) by means of intraperitoneal inoculations with protoscoleces. the cysts formed by the montana isolate were entire, hyaline, and translucent, whereas those produced by the alaska isolate were granular, yellowish, and opaque. vesicles of the montana isolate were larger, produced protoscoleces more slowly but in greater numbers, and ...19921597801
the ecology of echinococcus multilocularis (cestoda: taeniidae) on st. lawrence island, alaska. ii. helminth populations in the definitive host.the helminths of 1,579 arctic foxes from st. lawrence island were investigated by standard methods. the foxes, obtained mainly during the winter from fur trappers, harbored 22 species of helminths. four of those were trematodes, viz., maritrema afanassjewi belopol'skaia, 1952, orthosplanchnus pygmaeus iurakhno, 1967, plagiorchis elegans (rudolphi, 1802) and alaria marcianae (larue, 1917), each of which occurred in a single host. two species of cestodes, diphyllobothrium dendriticum (nitzsch, 182 ...19902080830
a programme to reduce the risk of infection by echinococcus multilocularis: the use of praziquantel to control the cestode in a village in the hyperendemic region of alaska.this paper reports the results of a 10-year field trial designed to reduce the risk of infection by echinococcus multilocularis to residents of a village in a hyperendemic area (savoonga, st. lawrence island). the objective was to prevent dispersal of infective eggs of the cestode within the village by means of monthly treatments of dogs with praziquantel. northern voles, microtus oeconomus, present in the village as commensals, served as an index of risk, as the incidence of infection in the vo ...19902222026
an elisa test for diagnosis and screening of echinococcus multilocularis in a high-risk inupiat eskimo population. 19883272716
risk factors for infection with echinococcus multilocularis in alaska.we studied 19 eskimo patients with alveolar hydatid disease from the north-western coast of alaska for risk factors for infection with echinococcus multilocularis. each case-patient was matched by age and sex with 2 unrelated controls who had no clinical or serologic evidence of infection with e. multilocularis and who resided in three villages endemic for alveolar hydatid disease. behaviors thought to increase exposure to e. multilocularis and the chronologic occurrence of these behaviors in th ...19883354771
demonstration of amyloid and immune complex deposits in renal and hepatic parenchyma of alaskan alveolar hydatid disease patients.histopathological changes and the incidence of amyloid and immune complex (ic) deposits were examined in six liver (autopsy or biopsy) and two kidney (autopsy) samples from seven alaskan alveolar hydatid disease (ahd) patients. both the kidney samples showed evidence of severe nephropathy and glomerular ic deposits. two of the six liver samples had typical amyloid deposits. all the liver samples examined showed variable amounts of parenchymal atrophy adjacent to the locus of larval echinococcus ...19873446028
rearing of the adult echinococcus multilocularis leuckart, 1863, from sterile larvae from man. 19734574754
alveolar hydatid disease. a review of clinical features of 33 indigenous cases of echinococcus multilocularis infection in alaskan eskimos.the clinical features of 33 cases of alveolar hydatid disease (ahd) in alaskan eskimos and a review of the surgical experience with this disease are presented. among untreated patients, progression of the disease to a fatal outcome was observed in 70%. the primary hepatic lesion resembles cancer, and errors in diagnosis by both the surgeon and pathologist are common. although surgical resection of the entire primary hepatic lesion offers the only proven curative treatment, only 26% of those expl ...19807446824
alveolar hydatid disease. review of the surgical experience in 42 cases of active disease among alaskan eskimos.the authors reviewed the pathophysiology and clinical management of endemic alveolar hydatid disease in alaskan eskimos, incorporating recent developments in diagnosis and treatment.19957717785
studies on the helminth fauna of alaska. xxx. the occurrence of echinococcus multilocularis leuckart, 1863, on the mainland of alaska. 195613381884
studies on the helminth fauna of alaska. xxxi. observations on the propagation of the larval echinococcus multilocularis leuckart, 1863, in vitro. 195713406659
new distribution records of echinococcus multilocularis in the brown lemming from barrow, alaska, usa.we identified echinococcus multilocularis for the first time in brown lemmings (lemmus trimucronatus) from barrow, alaska, usa. of 467 brown lemmings trapped between 1995 and 2000, two males and two females (0.9%; 95% confidence interval=0.9+/-0.9%) were found to be infected with metacestodes of e. multilocularis. no metacestodes were found in 17 collared lemmings (dicrostonyx rubricatus) also trapped at barrow. in humans, e. multilocularis causes alveolar echinococcosis, which is potentially fa ...200515827234
assessment of use of microsatellite polymorphism analysis for improving spatial distribution tracking of echinococcus multilocularis.alveolar echinococcosis (ae)--caused by the cestode echinococcus multilocularis--is a severe zoonotic disease found in temperate and arctic regions of the northern hemisphere. even though the transmission patterns observed in different geographical areas are heterogeneous, the nuclear and mitochondrial targets usually used for the genotyping of e. multilocularis have shown only a marked genetic homogeneity in this species. we used microsatellite sequences, because of their high typing resolution ...200717634311
genetic analysis of echinococcus multilocularis originating from a patient with alveolar echinococcosis occurring in minnesota in date, only a single proven case of autochthonous human alveolar echinococcosis has been recorded in minnesota in 1977. at that time, echinococcal lesions removed from the patient were experimentally inoculated into voles, and the parasite materials obtained from the voles were preserved as histopathologic specimens for 30 years. in this study, retrospective genetic analysis of larval echinococcus multilocularis originating in the human case was performed using the histopathologic specimens. d ...200818689631
tradition and transition: parasitic zoonoses of people and animals in alaska, northern canada, and greenland.zoonotic parasites are important causes of endemic and emerging human disease in northern north america and greenland (the north), where prevalence of some parasites is higher than in the general north american population. the north today is in transition, facing increased resource extraction, globalisation of trade and travel, and rapid and accelerating environmental change. this comprehensive review addresses the diversity, distribution, ecology, epidemiology, and significance of nine zoonotic ...201323548085
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