| unusual dengue virus 3 epidemic in nicaragua, 2009. | the four dengue virus serotypes (denv1-4) cause the most prevalent mosquito-borne viral disease affecting humans worldwide. in 2009, nicaragua experienced the largest dengue epidemic in over a decade, marked by unusual clinical presentation, as observed in two prospective studies of pediatric dengue in managua. from august 2009-january 2010, 212 dengue cases were confirmed among 396 study participants at the national pediatric reference hospital. in our parallel community-based cohort study, 170 ... | 2011 | 22087347 |
| correlation between dengue-specific neutralizing antibodies and serum avidity in primary and secondary dengue virus 3 natural infections in humans. | although heterotypic secondary infection with dengue virus (denv) is associated with severe disease, the majority of secondary infections are mild or asymptomatic. the mechanisms of antibody-mediated protection are poorly understood. in 2010, 108 denv3-positive cases were enrolled in a pediatric hospital-based study in managua, nicaragua, with 61 primary and 47 secondary infections. we analyzed denv-specific neutralization titers (nt50), igm and igg avidity, and antibody titer in serum samples c ... | 2013 | 23785536 |