| stable susceptibility of candida blood isolates to fluconazole despite increasing use during the past 10 years. | the prevalence of drug-resistant bacterial pathogens is very high in taiwan. accordingly, there was great concern that the introduction of fluconazole would result in rapid emergence of drug-resistant yeasts. thus, we recommended in 1991 that fluconazole be used for treatment only. to explore the impact of this policy fluconazole susceptibility of candida species blood culture isolates and outcome of patients with nosocomial candidaemia were monitored prospectively at national taiwan university ... | 2003 | 12775680 |
| fluconazole resistance rate of candida species from different regions and hospital types in taiwan. | from april 15 to june 15, 1999, 581 clinical candida isolates from 19 hospitals in taiwan were collected and susceptibilities to fluconazole of these isolates were determined by a broth microdilution method. a total of 42 (7.2%) isolates were resistant to fluconazole. isolates from medical centers had a higher resistance rate to fluconazole than those from regional hospitals (10.7% vs 4.9%). candida species isolated from different regions had different degrees of susceptibility to fluconazole. a ... | 2003 | 14582563 |
| in vitro activity of voriconazole against candida species isolated in taiwan. | the activity of voriconazole was determined against 285 candida species consisting of 53 resistant isolates, 43 susceptible-dose dependent and 189 isolates susceptible to fluconazole. the mic(50) and mic(90) to fluconazole were 8 and 64 mg/l, respectively. the range of minimum inhibitory concentrations (mics) to voriconazole was from 0.0325 to 2 mg/l and the mic(50) and mic(90) were 0.125 and 0.5 mg/l, respectively. only 3 of 285 tested isolates had mics to voriconazole equal to 2 mg/l. a total ... | 2004 | 15325436 |
| susceptibilities to amphotericin b and fluconazole of candida species in taiwan surveillance of antimicrobial resistance of yeasts 2006. | susceptibilities to amphotericin b and fluconazole of 964 candida isolates collected in taiwan surveillance of antimicrobial resistance of yeasts in 2006 were determined. there were 419 (43.5%) candida albicans, 246 (25.5%) candida tropicalis, 211 (21.9%) candida glabrata, 62 (6.4%) candida parapsilosis, 14 (1.5%) candida krusei, and 12 (1.2%) others. interestingly, 16 of the 17 amphotericin b-resistant isolates were non-albicans candida species. the resistant rate to amphotericin b has decrease ... | 2008 | 18304773 |
| the distribution of species and susceptibility of amphotericin b and fluconazole of yeast pathogens isolated from sterile sites in taiwan. | to study the demographic changes of yeasts causing invasive infections in taiwan, especially with respect to species distribution and antifungal susceptibility, we analyzed isolates obtained from four sterile sites of patients in 19 hospitals in 2002 (155 strains) and again from the same hospitals in 2006 (208 strains). blood was the most common source of the yeasts, accounting for 73.8% of the total isolates, followed by ascites (21.5%), cerebrospinal fluid (3%), and synovia (1.7%). candida alb ... | 2010 | 20141372 |
| characterization of candida species from different populations in taiwan. | the opportunistic candida species existing as part of commensal microbiota in humans are usually the etiological agents causing infections. we investigated whether isolates collected from different age groups, hospital units, and sources have distinct characteristics. a total of 913 isolates comprising 395 candida albicans, 230 candida tropicalis, 202 candida glabrata, 62 candida parapsilosis, 13 candida krusei, and 11 of other six species were analyzed. urine was the most common source (41.2%), ... | 2011 | 21369746 |
| time to blood culture positivity of different candida species causing fungemia. | this study investigated the time to positivity (ttp) of different species of candida causing bloodstream infection and whether ttp can help differentiate fluconazole-resistant candida glabrata and c. krusei from other candida species. we prospectively conducted this study at the national taiwan university hospital, a 2500-bed tertiary care medical center in northern taiwan. patients with candidemia were identified by central laboratory personnel from july 2010 to march 2011. ttp in each patient ... | 2012 | 22245787 |
| antifungal susceptibility of candida species isolated from patients with candidemia in southern taiwan, 2007-2012: impact of new antifungal breakpoints. | the clinical and laboratory standard institute (clsi) revised the clinical breakpoints (cbps) for the azoles and echinocandins against candida species in 2012. we aimed to report the epidemiology of candidemia and antifungal susceptibility of candida species and evaluate the impact of new cbps on antifungal susceptibility in our region. all blood isolates of candida species were obtained from 2007 to 2012. the minimum inhibitory concentrations of fluconazole, voriconazole, echinocandins and fluc ... | 2017 | 27621210 |
| an emerging issue of mixed yeast cultures. | different yeast species have different susceptibilities to commonly prescribed antifungal drugs. thus, it is important to accurately determine the species of pathogenic yeasts, especially when more than one species are in a specimen. | 2014 | 23523053 |
| clinical characteristics of candidaemia in adults with haematological malignancy, and antimicrobial susceptibilities of the isolates at a medical centre in taiwan, 2001-2010. | during the period 2001-2010, a total of 154 episodes of candidaemia were noted in 111 of 2574 patients with haematological malignancies at the national taiwan university hospital (taipei, taiwan). patients with acute lymphoblastic leukaemia had a significantly higher rate of candidaemia than patients with other haematological malignancies (odds ratio=2.69; p<0.001). candida tropicalis was the most common candida species (n=51; 46%), followed by candida albicans (n=35; 32%), candida parapsilosis ... | 2012 | 23006521 |
| association between incidence of candidaemia and consumption of antifungal agents at a medical centre in taiwan. | this study investigated the correlations between consumption of antifungal agents and species distribution in candidaemia. the incidence of patients with community-acquired candidaemia (cac) (per 1000 admissions) and healthcare-associated candidaemia (hcac) (per 1000 admissions) as well as data on annual consumption [defined daily doses (ddd)/1000 patient-days] of various antifungal agents at a medical centre in taiwan from 2000 to 2010 were evaluated. a total of 2682 episodes of candidaemia wer ... | 2012 | 22819796 |