Publications

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a mr 90 000 surface polypeptide of trypanosoma cruzi as a candidate for a chagas' disease diagnostic antigen.trypanosoma cruzi (peru strain) trypomastigotes and epimastigotes were biosynthetically labeled with [35s]methionine, and the proteins were analyzed by two dimensional polyacrylamide gel electrophoresis (2d-page). 2d-page analysis of the trypomastigotes showed a complex array of polypeptides with distinct clusters at mr 88 000-92 000, isoelectric point (pi) 5.6-6.0, and mr 72 000-76 000, pi 5.6-5.8. 2d-page analysis of the epimastigotes did not show the cluster of polypeptides at mr 90 000. when ...19853932849
force of infection and evolution of lesions of canine tegumentary leishmaniasis in northwestern argentina.a clinical-serological follow-up was carried out in a canine population in endemic foci of leishmania braziliensis spread in northwestern argentina. each dog was studied in at least two visits, 309+/-15 days (x+/-se) apart. some initially healthy dogs (n=52) developed seroconversion or lesions. the clinical evolution of the disease in dogs resembles in many aspects the human disease. similarities include the long duration of most ulcers with occasional healing or appearance of new ones and the l ...200111500762
characterization of human infection by leishmania spp. in the northwest of argentina: immune response, double infection with trypanosoma cruzi and species of leishmania involved.the aims of this study were to characterize human american tegumentary leishmaniasis, which includes cutaneous, mucocutaneous and mucosal leishmaniasis, in northwest argentina, to determine the prevalence of double infection with trypanosoma cruzi and to identify the species of leishmania in this area. most of the 330 leishmaniasis patients presented cutaneous ulcers (96.1%), 2.4% mucocutaneous and 1.5% the mucosal form ('espundia'). the aetiological agents, determined by isoenzyme electrophores ...200312613761
a randomized clinical trial comparing oral azithromycin and meglumine antimoniate for the treatment of american cutaneous leishmaniasis caused by leishmania (viannia) braziliensis.azithromycin was compared with meglumine antimoniate for treatment of patients with cutaneous leishmaniasis. patients were randomized to receive oral azithromycin, 500 mg/day (22 patients) or intramuscular meglumine antimoniate, 10 mg sb/kg/day (23 patients), both for 28 days, with a second cycle of 15 days if necessary, and followed-up for one year after completion of treatment. efficacy, defined as complete re-epithelization without relapse for 12 months after completing therapy, was 82.6% (95 ...200717978064
a novel molecular test to diagnose canine visceral leishmaniasis at the point of care.dogs are the principal reservoir hosts of zoonotic visceral leishmaniasis (vl) but current serological methods are not sensitive enough to detect all subclinically infected animals, which is crucial to vl control programs. polymerase chain reaction (pcr) methods have greater sensitivity but require expensive equipment and trained personnel, impairing its implementation in endemic areas. we developed a diagnostic test that uses isothermal recombinase polymerase amplification (rpa) to detect leish ...201526240156
multilocus sequence typing approach for a broader range of species of leishmania genus: describing parasite diversity in argentina.leishmaniasis is a vector-borne protozoan infection affecting over 350 million people around the world. in argentina cutaneous leishmaniasis is endemic in nine provinces and visceral leishmaniasis is spreading from autochthonous transmission foci in seven provinces. however, there is limited information about the diversity of the parasite in this country. implementation of molecular strategies for parasite typing, particularly multilocus sequence typing (mlst), represents an improved approach fo ...201525558029
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