a retrospective study of circovirus infection in pigeons: nine cases (1986-1993).circovirus infections were diagnosed in 12 pigeons from the united states 4 pigeons from australia, and 1 pigeon from canada (1986-1993). circovirus was identified by electron microscopic examination of basophilic botryoid cytoplasmic inclusions that had a histologic appearance similar to that of psittacine beak and feather disease virus inclusions. inclusions were seen in splenic, bursal, gut-associated, and bronchus-associated lymphoid tissue macrophages and in bursal epithelial cells. inclusi ...19948068746
observations on pigeon circovirus infection in ontario.subclinical pigeon circovirus infection was diagnosed in 1-day-old to 6-week-old birds from a loft with no history of clinical disease. pigeons from other lofts presented with various illnesses and were found at necropsy to be concurrently infected with pigeon circovirus.199910495910
genome sequence determinations and analyses of novel circoviruses from goose and pigeon.the genomes of novel circoviruses from goose and pigeon, which were isolated using degenerate primer and inverse primer pcr methods, were cloned and sequenced. comparative nucleotide (nt) sequence analyses showed that the goose circovirus (gcv) and pigeon circovirus (picv) possessed genomes which were 1821 and 2037 or 2036 nt, respectively, and which had features in common with the genomes of porcine circoviruses types 1 and 2 (pcv1, pcv2) and psittacine beak and feather disease virus (bfdv), su ...200111485403
detection of circovirus infection in pigeons by in situ hybridization using cloned dna probes.degenerate primers were designed based on known sequence information for the circoviruses psittacine beak and feather disease virus and porcine circovirus and applied by polymerase chain reaction (pcr) to known virus-infected bursa of fabricius (bf) from a pigeon. a 548-bp dna fragment was amplified and shown to be specific to a novel circovirus, named pigeon circovirus (picv), and was used to produce sensitive and specific probes for detection of circovirus dna by in situ hybridization (ish). u ...200111724137
a method to diagnose pigeon circovirus infection in vivo.this study describes a method to detect in vivo pigeon circovirus (picv, also called columbid circovirus, cocv) identified recently. blood samples of healthy and diseased pigeons were investigated. dna was isolated from a drop of blood spotted and dried on filter paper. a nested pcr using two primer pairs from the cap gene was performed to detect picv. using this method, picv nucleic acid was detected in 17 of 53 pigeons examined. pcr using dna from dried blood samples is a simple, fast and reli ...200212020792
evaluation of polymerase chain reaction and dot blot hybridisation tests in the diagnosis of pigeon circovirus infections.polymerase chain reaction (pcr) and dot blot hybridisation (dbh) tests for detecting pigeon circovirus (picv) dna were developed and evaluated using tissue samples obtained from diseased and clinically normal pigeons, which originated in belgium and northern ireland. when pcr product was visually detected, the limit of detection of the pcr test was 31 fg, while that of the dbh was 1.6p g. for evaluation purposes, the results of the pcr and dbh tests, performed with dnas extracted from samples of ...200212223158
detection of pigeon circovirus by polymerase chain reaction.pigeon circovirus was identified by polymerase chain reaction (pcr) in young pigeons belonging to 12 different lofts. viral dna was extracted from formalin-fed, paraffin-imbedded tissues containing primarily bursa and occasionally liver and spleen with a commercial kit. pcr primers were selected from a published sequence for columbid circovirus and evaluated in a pcr assay. the histopathologic examination of various tissues revealed basophilic globular intracytoplasmic inclusions in the mononucl ...200312713182
avian circovirus diseases: lessons for the study of pmws.the diseases associated with psittacine beak and feather disease virus (bfdv), pigeon circovirus (picv) and goose circovirus (gocv), which can be classified with porcine circovirus type 2 (pcv2) as members of the genus circovirus of the family circoviridae, have clinico-pathological features in common with post-weaning multisystemic wasting syndrome (pmws), with which pcv2 infection is causally associated. intracytoplasmic botryoid inclusions within macrophages and depletion of t and b lymphocyt ...200414741130
new data on the transmission of pigeon circovirus.nineteen racing pigeons aged from one to five years were examined postmortem. pcr tests showed that the spleens of 16 of them were positive for pigeon circovirus, the livers of six were positive, and blood from one of them was positive for the virus. five of 44 embryos in embryonated eggs collected from three lofts were positive by pcr, but swabs taken from the crops of 64 adult birds which were feeding one- to 10-day-old squabs in these three lofts were negative for the viral dna.200516199776
a disease complex associated with pigeon circovirus infection, young pigeon disease order to collect more convincing data on the aetiological agent of young pigeon disease syndrome (ypds), a comprehensive study was performed on pigeons in german lofts with or without outbreaks of ypds. the investigations included examination of histories, clinical signs and pathology, as well as parasitological and microbiological analysis. pigeons in their 4th to 12th week of life exhibited clinical signs at higher frequency and with greater severity than pigeons of other ages. greenish liq ...200516236576
development of a polymerase chain reaction-based in vivo method in the diagnosis of subclinical pigeon circovirus infection.this paper describes a polymerase chain reaction (pcr)-based method performed on blood samples and intestinal content to detect subclinical pigeon circovirus (picv) infection in live pigeons. in addition, two sets of primers (primer set 1 and 2), designed in two different regions of the viral genome, were used to provide evidence of possible differences in pcr responses. blood and intestinal content samples were randomly collected from a total of 50 apparently healthy meat pigeons, aged 1 to 5 w ...200516252485
observations on detection, excretion and transmission of pigeon circovirus in adult, young and embryonic pigeons.infections with pigeon circovirus (picv) occur in young racing pigeons and pigeons raised for meat production and have been reported worldwide, but relatively little is known about the disease induced by picv infection. the aim of this study was to investigate how picv is transmitted. using a sensitive polymerase chain reaction (pcr) test, the presence of picv was investigated in a wide range of samples from adult pigeons, embryos, breeders and young birds, which were derived from a racing loft ...200616448939
identification of a novel circovirus in australian ravens (corvus coronoides) with feather disease.the complete genome of a novel circovirus isolated from an australian raven (corvus coronoides) with feather lesions similar to those that occur in psittacine beak and feather disease is reported. degenerate polymerase chain reaction primers were designed to amplify and sequence novel circovirus dna from affected feathers. sequence analysis indicated that the tentatively named raven circovirus (racv) was 1898 nucleotides in size with two major open reading frames synonymous with other avian circ ...200616595298
detection of pigeon circovirus in cloacal swabs: implications for diagnosis, epidemiology and control.pigeon circovirus (picv) was detected in cloacal swab samples by means of a newly-developed, sensitive pcr. an initial investigation of 17 belgian racing pigeons aged up to eight months showed that rates of detection of 88 per cent and above were achieved using samples of cloacal swab, blood and bursa of fabricius. the sampling of 15 caged pigeons six times when they were from three to 31 weeks of age indicated that picv infections were more readily detected in cloacal swabs than in blood, and t ...200616950888
molecular characterization of novel circoviruses from finch and gull.the purpose of this study was to molecularly characterize circoviruses that infect finches and gulls. circovirus-specific dnas were isolated using polymerase chain reaction methods from bursa of fabricius tissues from a gouldian finch (chloebia gouldiae) and a herring gull (larus argentatus) that were known to be circovirus-infected. nucleotide sequence determination and analysis of cloned genomic dnas showed that these circoviruses represented novel members of the genus circovirus of the family ...200717364513
rapid detection of pigeon herpesvirus, fowl adenovirus and pigeon circovirus in young racing pigeons by multiplex pcr.infections of young racing pigeons with pigeon herpesvirus (pihv), fowl adenovirus (fadv) and pigeon circovirus (picv) are reported frequently. the role of these viruses in the pathogenesis of a disease complex called young pigeon disease syndrome (ypds) is generally accepted. all of these viruses cause inclusion bodies in the liver so liver samples are particularly useful for the detection of infection. consequently a multiplex polymerase chain reaction (pcr) was developed for the detection of ...200818215428
experimental infection of domestic pigeons with pigeon circovirus.pigeon circovirus (picv) infection and young pigeon disease syndrome (ypds), associated with high morbidity and mortality, have been recognized in young racing pigeons from large portions of central europe. there exist a number of data indicating that ypds is a consequence of picv infection and subsequent immunosuppression. in order to prove picv to be one of the crucial factors of ypds, an experimental infection with picv was performed under controlled conditions. twenty-four domestic pigeons ( ...200818939623
circoviruses: immunosuppressive threats to avian species: a review.circoviruses are small, non-enveloped, icosahedral viruses that are unique among animal viruses in having circular, single-stranded dna genomes. their genomes are also the smallest possessed by animal viruses. the circovirus family currently comprises three members, chicken anaemia virus, porcine circovirus, and psittacine beak and feather disease virus, with pigeon circovirus being classified as a tentative member. infections with each of the four circoviruses are associated with potentially fa ...200019184829
pigeon circovirus infection: pathological observations and suggested pathogenesis.pigeon circovirus infection (picv) was diagnosed by light and transmission electron microscopy in 15 birds from five lofts in western france. histopathological findings were suggestive of primary bursotropism of pigeon circovirus, followed by secondary systemic spread from the bursa of fabricius, particularly to non-bursal lymphoid organs. the last stage of the disease was associated with various secondary (particularly bacterial) infections. in situ detection of apoptosis in the bursa of fabric ...200119184889
nucleotide sequence-based identification of a novel circovirus of canaries.circovirus-like, spherical particles measuring 16 to 18 nm in diameter were detected in organ homogenates from adult canaries that had died after a short illness characterized by dullness, anorexia, lethargy and feather disorder. a polymerase chain reaction method, based on degenerate primers specific to conserved amino acid sequences in the circovirus replication-associated protein, was used to amplify dna specific to a novel circovirus, tentatively named canary circovirus (ccv). sequence analy ...200119184917
cloning and expression of a truncated pigeon circovirus capsid protein suitable for antibody detection in infected pigeons.infections with pigeon circovirus (picv) (also termed columbid circovirus) occur in meat and racing pigeons (columba livia) of all ages and have been reported worldwide. a picv infection is associated with immunosuppression and the development of young pigeon disease syndrome. an indirect enzyme-linked immunosorbent assay (elisa) for the detection of virus-specific serum antibody was developed for research purposes. in the absence of a method to propagate picv in cell culture, the assay was base ...200919322712
quantification of pigeon circovirus in serum, blood, semen and different tissues of naturally infected pigeons using a real-time polymerase chain reaction.the development of a real-time polymerase chain reaction (pcr) based on sybr green chemistry is described for the quantification of pigeon circovirus (picv) dna in various samples. plasmid containing a fragment of the picv genome was used to create a standard curve and to estimate the viral dna copies in analysed samples. both primers were designed in highly conserved regions to avoid false negatives, and amplified a 139-base-pair amplicon. when the amplifications were performed in the presence ...200919322713
[cloning and analysis of the complete genomes of pigeon circovirus from zhejiang province].pigeon circovrius (picv) is a member of circovirus, which is usually regarded as an immunosuppression agent. there were reports that pigeons infected by picv showed symptoms of lethargy, weight loss, vomiting, diarrhea, respiratory distress, etc. in this study, we established a pcr method for the detection of picv dna. samples from 5 different farms in zhejiang province were examined and samples from a farm in hangzhou were positive. furthermore, the genomic segments of 2 strains of picv were am ...200919954112
effect of a commercial paratyphus vaccine on the development of pigeon circovirus infection in young pigeons (columba livia domestica).infection with pigeon circovirus (picv) has been associated with young pigeon disease syndrome (ypds), which is considered to be a multifactorial disease. the factors that determine whether birds succumb to clinical disease are not known. to evaluate the potential effect of vaccination with a commercial paratyphus vaccine on the progression of picv infection in young pigeons, forty 6-week-old pigeons naturally infected with picv were randomly assigned to two equal groups. the pigeons of one grou ...201020806655
the development of a rapid sybr green i-based quantitative pcr for detection of duck circovirus.this report describes a one-step real-time polymerase chain reaction assay based on sybr green i for detection of a broad range of duck circovirus (ducv). align with all ducv complete genome sequences and other genus circovirus download from the genbank (such as goose circovirus, pigeon circovirus), the primers targets to the replicate gene of ducv were designed. the detection assay was linear in the range of 1.31 × 102-1.31 × 107 copies/μl. the reaction efficiency of the assay using the slope ( ...201121978576
genetic diversity of pigeon circovirus in hungary.pigeon circoviruses (picv) had been identified worldwide and are responsible for immune suppression and a variety of diseases collectively referred to as young pigeon disease syndrome. samples from racing pigeons were collected throughout hungary and analyzed for the presence of picv by polymerase chain reaction. the capsid protein coding gene was amplified from ten picvs of different origins, and compared with known picv sequences. the results indicated that picv was highly variable, the viruse ...201121922293
molecular characterization and epidemiological investigation of pigeon circovirus isolated in eastern investigate the prevalence and genetic characterization of pigeon circovirus (picv) circulating in chinese flocks, the genomic dna of 144 samples collected from pigeons in 6 different geographic regions of eastern china between 2009 and 2010 were amplified using previously published picv primers. the picv sequence was detected in 83 of 104 unhealthy pigeons (79.8%) and 25 of 40 healthy pigeons (62.5%). the overall positive rate was 75% for all samples. an inverse primer polymerase chain react ...201121908307
occurrence of bacterial and viral pathogens in common and noninvasive diagnostic sampling from parrots and racing pigeons in slovenia.airborne pathogens can cause infections within parrot (psittaciformes) and pigeon (columbiformes) holdings and, in the case of zoonoses, can even spread to humans. air sampling is a useful, noninvasive method which can enhance the common sampling methods for detection of microorganisms in bird flocks. in this study, fecal and air samples were taken from four parrot holdings. additionally, cloacal and oropharyngeal swabs as well as air samples were taken from 15 racing pigeon holdings. parrots we ...201627309292
evidence of a deep viral host switch event with beak and feather disease virus infection in rainbow bee-eaters (merops ornatus).since the characterization of psittacine beak and feather disease (pbfd) in 1984, a wide range of avian circoviruses have been discovered with varying pathogenic effects amongst a diverse range of avian hosts. until recently these circovirus species were thought to be restricted to within avian orders such as the psittaciformes for beak and feather disease virus (bfdv) and columbiformes for pigeon circovirus with little evidence of cross-family transmission or replication. we report evidence of ...201526411487
pigeon circoviruses display patterns of recombination, genomic secondary structure and selection similar to those of beak and feather disease viruses.pigeon circovirus (picv) has a ~2 kb genome circular ssdna genome. all but one of the known picv isolates have been found infecting pigeons in various parts of the world. in this study, we screened 324 swab and tissue samples from polish pigeons and recovered 30 complete genomes, 16 of which came from birds displaying no obvious pathology. together with 17 other publicly available picv complete genomes sampled throughout the northern hemisphere and australia, we find that picv displays a similar ...201424639400
epidemiology and genetic characteristics of pigeon circovirus (picv) in eastern china.pigeon circovirus (picv) is one of four viruses in the family circoviridae that affect young pigeons around the world. we collected 158 serum or tissue samples from six poultry farms in eastern china to investigate the prevalence and genetic characteristics of picv in chinese pigeons. we tested for picv using a pcr assay and found that picv was present in 80.7 % (88/109) of diseased pigeons and 63.3 % (31/49) of healthy pigeons; overall, 75.3 % (119/158) of samples were picv positive. one picv-p ...201525348272
the prevalence and genetic characterization of chlamydia psittaci from domestic and feral pigeons in poland and the correlation between infection rate and incidence of pigeon circovirus.chlamydiosis is a zoonotic disease caused by chlamydia psittaci that occurs in a wide range of bird species. high infection rates with c. psittaci are found in pigeons, which can act as vectors transmitting this bacterium to poultry and humans. chlamydia shedding by pigeons is intermittent and can be activated by stressors or immunosuppression. the most common immunosuppressive factor for pigeons is a pigeon circovirus (picv) infection. the main aim of the study was to evaluate the prevalence of ...201425306457
development of a loop-mediated isothermal amplification method for rapid detection of pigeon circovirus.there are no effective antiviral treatments for pigeon circovirus (picv); thus, rapid diagnosis is critical for effective control of the disease caused by this virus. the recent development of a novel lamp technique that amplifies nucleic acids rapidly with high specificity and sensitivity under isothermal conditions has overcome some of the deficiencies of nucleic-acid-based diagnostic tests. we established a lamp method for rapid detection of picv using two pairs of primers that were designed ...201424193953
epidemiological investigation of selected pigeon viral infections in poland.due to a lack of data in regard to the spread of viral infections in polish pigeon populations, studies were undertaken to assess the frequency of adeno-, circo- and herpesvirus infections in flocks of pigeons across the entire country. in total, 107 flocks were examined, of which 61 per cent consisted of racing and 39 per cent of fancy pigeons. the flocks were divided into groups according to breed (racing and fancy pigeons) as well as physical condition (healthy and sick). in the studied pigeo ...201223118041
application of pigeon circovirus recombinant capsid protein for detecting anti-picv antibodies in the sera of asymptomatic domestic pigeons and the potential use of a combination of serological and molecular tests for controlling circovirus infections in pigeon breeding flocks.the aim of this study was to evaluate the serologic status of domestic pigeons not infected and asymptomatically infected with the pigeon circovirus (picv) with the use of an enzyme-linked assay based on picv recombinant capsid protein as a plate antigen. recombinant picv capsid protein was produced by transforming e. coli bl21 (de3) rosetta colonies with expression plasmids.blood samples and cloacal swabs were collected from 171 asymptomatic pigeons. the birds were divided into two groups (infe ...201727578880
high yield production of pigeon circovirus capsid protein in the e. coli by evaluating the key parameters needed for protein expression.pigeon circovirus (picv) is considered to be a viral agent central to the development of young pigeon disease syndrome (ypds). the cap protein, a structural protein encoded by the cap (or c1) gene of picv, has been shown to be responsible for not only capsid assembly, but also has been used as antigen for detecting antibody when the host is infected with picv. the antigenic characteristics of the cap protein potentially may allow the development of a detection kit that could be applied to contro ...201424886262
what's in a strain? viral metagenomics identifies genetic variation and contaminating circoviruses in laboratory isolates of pigeon paramyxovirus type 1.we used next generation sequencing on random amplified viral nucleic acids to determine the genome sequence of 11 pigeon paramyxovirus type 1 (ppmv-1) isolates from belgium (period 1998-2011). the ppmv-1 deep sequence data allowed identification of sequence variability in multiple ppmv-1 isolates, including one stop codon in the matrix gene which was present in 15% of the viral population of one isolate. notably, mutations that were previously associated with pathogenicity in chickens were ident ...201323220336
pigeon circovirus infection in disqualified racing pigeons from taiwan.pigeons (columba livia) infected with pigeon circovirus (picv) have been reported worldwide. the present study diagnosed picv infection in tissue samples of disqualified racing pigeons in taiwan, using molecular and microscopy diagnostics. among the 164 dead pigeons examined, 96.95% (159/164) tested positive for picv. severe histopathological lesions, with characteristic inclusions, were observed in various organs of the picv-infected pigeons. multiglobular basophilic intranuclear and intracytop ...201728132523
complete genome sequence of pigeon circovirus detected in racing pigeons in western japan.we report the genetic analysis of a pigeon circovirus (picv/japan/2/2010) detected in a racing pigeon with diarrheal symptoms in western japan. sequencing revealed a genome size of 2,041 bp that contained 3 open reading frames (orfs), designated v1, c1, and c2, a structure consistent with to those of other pigeon circoviruses. phylogenetic analyses of the orf c1 revealed that picv/japan/2/2010 diverges from other asian pigeon circoviruses, suggesting genetic diversity of pigeon circoviruses in a ...201526066052
prevalence of pigeon circovirus infections in feral pigeons in ljubljana, slovenia.pigeon circovirus (picv) was detected by real-time pcr in cloacal swabs, pharyngeal swabs, and serum samples taken from 74 feral pigeons (columba livia var. domestica) that were caught at various locations in the city of ljubljana, slovenia. picv infections were detected in the majority of the tested birds. the highest (74.3%) detection rate was observed in the cloacal swabs and the lowest (31.1%) in serum samples. picv dna was more readily detected in the cloacal swabs, pharyngeal swabs, and se ...201222856208
the epidemiology, molecular characterization and clinical pathology of circovirus infections in pigeons - current knowledge.the first cases of circovirus infections in pigeons were documented less than 25 years ago. since then, circovirus infections have been reported on nearly all continents. the specificity of pigeon breeding defies biosecurity principles, which could be the reason for the high prevalence of picv infections. picv infections in pigeons lead to atrophy of immune system organs and lymphocyte apoptosis. infected birds could be more susceptible to infections of the respiratory and digestive tract. picv ...201728463055
genome sequence characterization of pigeon circoviruses in china.pigeon circovirus (picv) was detected by pcr in pigeons from china. altogether, 48 out of 244 pigeons tested positive for picv (positive rate, 19.67%), suggesting that the virus was prevalent in china. from the 48 picv-positive samples, about 2040bp complete genome fragments were obtained by full length genome amplification and sequenced with a next-generation sequencing platform. characteristics of the orfs from different picv strains tested in this study were analyzed. several insertion, delet ...201728268176
recurrent positive selection and heterogeneous codon usage bias events leading to coexistence of divergent pigeon circoviruses.the capsid genes from 14 pigeon circovirus (picv) sequences, collected from taiwan between 2009 and 2010, were sequenced and compared with 14 picv capsid gene sequences from genbank. based on pairwise comparison, picv strains from taiwan shared 73.9-100% nucleotide identity and 72-100% amino acid identity with those of the 14 reported picv sequences. phylogenetic analyses revealed that taiwanese picv isolates can be grouped into two clades: clade 1 comprising isolates from belgium, australia, us ...201525911731
detection and phylogenetic characterization of columbid circoviruses in chaharmahal va bakhtiari province, iran.the virus genus circovirus belongs to the family circoviridae and contains virus species with circular single-stranded dna genomes. the viruses are known to infect vertebrate species, including pigs, dogs, pigeons and ducks. in this study a nested polymerase chain reaction (pcr) was applied to investigate prevalence of circoviruses in pigeons in the chaharmahal va bakhtiari province, iran. a total of 50 faecal samples were subjected to nucleic acid extraction, pcr amplification and dna sequencin ...201425248026
occurrence and genetic diversity of pigeon circovirus strains in poland.pigeon circovirus (picv) is an immunosuppressive agent widespread throughout the world, which causes a disease in pigeons called young pigeon disease syndrome. the aim of the study was to evaluate the prevalence of picv in poland and investigate the genetic diversity relative to other known picv isolates. samples from 152 pigeon flocks (88 flocks of racing pigeons and 64 flocks of fancy pigeons) from various regions of poland were tested by polymerase chain reaction and an approximately 326-base ...201424659711
recombinant goose circoviruses circulating in domesticated and wild geese in poland.circoviruses are circular single-stranded dna (ssdna) viruses that infect a variety of animals, both domestic and wild. circovirus infection in birds is associated with immunosuppression and this in turn predisposes the infected animals to secondary infections that can lead to mortality. farmed geese (anser anser) in many parts of the world are infected with circoviruses. the majority of the current genomic information for goose circoviruses (gocvs) (n= 40) are from birds sampled in china and ta ...201829498637
probiotic supplementation containing bacillus velezensis enhances expression of immune regulatory genes against pigeon circovirus in pigeons (columba livia).in this study, we aimed to isolate and evaluate the efficacy of bacillus velezensis as a probiotic and to assess its activity towards pigeons infected with pigeon circovirus (picv).202033048404
influence of pigeon interferon alpha (piifn-α) on pigeon circovirus (picv) replication and cytokine expression in columba livia.pigeon circovirus (picv) is the most diagnosed virus in pigeons (columba livia) and have been studied and reported globally. picv infections can lead to immunosuppression and pigeons infected with picv can result to lymphocyte apoptosis and atrophy of immune organs. young pigeon disease syndrome (ypds) is a complex disease and believed that picv could be one of the agents leading to this syndrome. an effective treatment regimen is needed to control the spread of picv in pigeons. in this study pi ...202032122595
comparison of the immune response to vaccination with pigeon circovirus recombinant capsid protein (picv rcp) in pigeons uninfected and subclinically infected with picv.infections with immunosuppressive pigeon circovirus (picv) pose the most severe health problem to the global pigeon breeding. the vaccination with immunogenic picv recombinant capsid protein (picv rcp) is a potential tool for disease control. because of the high prevalence of picv asymptomatic infections, the subclinically infected pigeons will be vaccinated in practice. the aim of this study was to answer a question if vaccination of asymptomatic, infected with picv pigeons induces a similar im ...201931251772
pigeon circoviruses from feral pigeons in australia demonstrate extensive recombination and genetic admixture with other other avian circovirus species, pigeon circovirus (picv) is known to be genetically diverse with a relatively small circular single-stranded dna genome of 2 kb that encodes for a capsid protein (cap) and a replication initiator protein (rep). recent paleoviral evidence hints towards a probable gondwanan origin of avian circoviruses, paralleling the evolution and dispersal of their hosts. limited availability of picv genome sequence data in australia has hindered phylogeographic studies in t ...201931199167
immunogenicity of pigeon circovirus recombinant capsid protein in pigeons.pigeon circovirus (picv) is the most frequently diagnosed virus in pigeons and is thought to be one of the causative factors of a complex disease called the young pigeon disease syndrome (ypds). the development of a vaccine against this virus could be a strategy for ypds control. since laboratory culture of picv is impossible, its recombinant capsid protein (rcp) can be considered as a potential antigen candidate in sub-unit vaccines. the aim of this basic research was to evaluate the immune res ...201830384424
columbid circoviruses detected in free ranging pigeons from southern brazil: insights on picv evolution.pigeon circovirus (picv) is taxonomically classified as a member of the circovirus genus, family circoviridae. the virus contains a single stranded dna genome of approximately 2 kb, with minor length variations among different isolates. the occurrence of picv infections in pigeons (columba livia) has been documented worldwide over the past 20 years; however, in brazil there were still no reports on picv detection. this study identifies seven picv genomes recovered from domestic pigeons of south ...201830105520
a pilot study investigating the dynamics of pigeon circovirus recombination in domesticated pigeons housed in a single loft.pigeon circovirus (picv) infects pigeon populations worldwide and has been associated with immunosuppression in younger pigeons. recombination is a common mechanism of evolution that has previously been shown in various members of the circoviridae family, including picv. in this study, three groups of pigeons acquired from separate lofts were screened for picv, and their genome sequence was determined. following this, they were housed in a single loft for 22 days, during which blood and cloacal ...202134067378
pigeon rotavirus a genotype g18p17-associated disease outbreaks after fancy pigeon shows in germany - a case series.pigeon rotavirus a (rva) isolates of genotype g18p[17] are causing disease outbreaks and fatalities in pigeon lofts in australia, germany, belgium, denmark and usa since 2016. most disease outbreaks have been reported from juvenile pigeons (columba livia forma domestica). however, reports on rva-associated disease outbreaks in fancy pigeons in connection with fancy pigeon shows in germany are rare.202133588462
immunogenicity and protective activity of pigeon circovirus recombinant capsid protein virus-like particles (picv rcap-vlps) in pigeons (columba livia) experimentally infected with picv.pigeon circovirus (picv) is the most recurrent virus diagnosed in pigeons and is among the major causative agents of young pigeon disease syndrome (ypds). due to the lack of an established laboratory protocol for picv cultivation, development of prophylaxis is hampered. alternatively, virus-like particles (vlps), which closely resemble native viruses but lack the viral genetic material, can be generated using a wide range of expression systems and are shown to have strong immunogenicity. therefo ...202133525416
investigation of lethal concurrent outbreak of chlamydiosis and pigeon circovirus in a zoo.during the spring, an outbreak of sudden death involving 58 birds occurred in a zoo. histopathological examinations revealed variable numbers of intracytoplasmic basophilic microorganisms in the macrophages, hepatocytes, and renal epithelium of most birds, along with occasional botryoid intracytoplasmic inclusion bodies within histiocytes in the bursa of fabricius. based on the results of histopathological examinations, immunohistochemical staining, transmission electron microscopy, and polymera ...202134199449
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