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prion strain causing bovine spongiform encephalopathy (bse) in cattle. 200211807378
resistance of domestic cats to a us sheep scrapie agent by intracerebral route.feline spongiform encephalopathy (fse) is thought to have resulted from consumption of food contaminated with bovine spongiform encephalopathy and the latter is believed to result from the consumption of food contaminated with scrapie. however, no direct experimental documentation exists to indicate that the scrapie agent is capable of amplifying in cats, and, therefore, crossing the species barrier. during 1979, 6 cats ranging in age from 3.5 to 18 months were intracerebrally inoculated with sh ...200212296404
could pets be of help in achieving health literacy? a media analysis demonstration study.this paper asks whether, when seeking to reach the public, interest in the health of pets merits consideration. our data set consisted of 128 items from canadian media coverage, 1996-2006, that dealt with bovine spongiform encephalopathy (bse) as well as with cats, dogs or both. three main messages regarding pet health and human health were identified: 'do not worry', 'do worry' and 'be cautious'. a minority of articles did not convey a pet health message or a human health message (6%), and cont ...200918359950
susceptibility of domestic cats to chronic wasting disease.domestic and nondomestic cats have been shown to be susceptible to feline spongiform encephalopathy (fse), almost certainly caused by consumption of bovine spongiform encephalopathy (bse)-contaminated meat. because domestic and free-ranging nondomestic felids scavenge cervid carcasses, including those in areas affected by chronic wasting disease (cwd), we evaluated the susceptibility of the domestic cat (felis catus) to cwd infection experimentally. cohorts of 5 cats each were inoculated intrace ...201323236066
neuropathology of italian cats in feline spongiform encephalopathy surveillance.feline spongiform encephalopathy (fse) is a transmissible spongiform encephalopathy associated with the consumption of feedstuffs contaminated with tissue from bovine spongiform encephalopathy-affected cattle and characterized by the accumulation in the central nervous system of an abnormal isoform of the prion protein (prp(sc)). clinically, it presents as a progressive fatal neurologic syndrome that is not easily distinguished from other feline neurologic conditions. most cases of fse have been ...200818725465
proteinase k enhanced immunoreactivity of the prion protein-specific monoclonal antibody 2a11.here, we report the development and further characterisation of a novel prp-specific monoclonal antibody: 2a11. by western blot analysis, 2a11 reacts with prpc from a variety of species including cow, sheep, pig, hamster, rabbit, cat, dog, deer and mouse but fails to react with human, chicken and turtle prp. reactivity to prpc in western blot was found to be dependent on the redox state of the protein since binding of mab 2a11 to its epitope was more effective in reducing conditions. 2a11 bindin ...200414687883
[bse and creutzfeldt-jakob disease. implication on health politics in germany and europe]. 200211845391
inconsistent detection of prp in extraneural tissues of cats with feline spongiform encephalopathy.feline spongiform encephalopathy (fse), a transmissible spongiform encephalopathy or prion disease of cats, first reported in great britain in 1990, is believed to result from the consumption of food contaminated by the agent of bovine spongiform encephalopathy (bse). the accumulation of prp in non-neural tissues of cats diagnosed as suffering from fse was investigated by immunohistochemistry. in the majority of the cats no disease-specific prp was detected in lymphoid tissues. small amounts of ...200111338713
cows, cats, and fse: death penalty justified?transmissible spongiform encephalopathies affect a number of mammalian species. the most common spongiform encephalopathies are scrapie in sheep and bovine spongiform encephalopathy (bse) in cattle. feline spongiform encephalopathy (fse) is a related disorder in domestic cats. because of the link between bse and fse, cats are put on a par with cattle, in terms of politics and regulations. in the netherlands, when a case of bse is found on a farm, not only the ruminants, but also the cats are tak ...200111206004
[transmissible spongiform encephalopathies in animals].transmissible spongiform encephalopathies in animals are known for centuries. in particular scrapie in sheep and goats occurs worldwide; it spreads as a natural disease and is genetically controlled. chronic wasting disease (cwd) in the united states (wyoming and colorado) also spreads as natural disease among free ranging and captive elk and mule deer. in contrast, transmissible mink encephalopathy (tme) of mink in fur producing farms is caused by contaminated feed; the source of this food cont ...19989611347
the biology and molecular biology of scrapie-like diseases.the transmissible spongiform encephalopathies (tse's) are degenerative diseases of the central nervous system which naturally affect man (creutzfeldt-jakob disease [cjd], gerstmann-sträussler syndrome [gss], kuru), sheep and goats (scrapie), cattle (bovine spongiform encephalopathy [bse]), mink (transmissible mink encephalopathy), mule deer, elk and antelope (chronic wasting disease). spongiform encephalopathies have also been diagnosed in captive species of zoo antelope and in domestic cats. mu ...19938219804
possible case of maternal transmission of feline spongiform encephalopathy in a captive cheetah.feline spongiform encephalopathy (fse) is considered to be related to bovine spongiform encephalopathy (bse) and has been reported in domestic cats as well as in captive wild cats including cheetahs, first in the united kingdom (uk) and then in other european countries. in france, several cases were described in cheetahs either imported from uk or born in france. here we report details of two other fse cases in captive cheetah including a 2(nd) case of fse in a cheetah born in france, most likel ...200919738899
lingering doubts about spongiform encephalopathy and creutzfeldt-jakob disease.bovine spongiform encephalopathy (bse) is an infectious disease and has been transmitted orally to many other animals, including humans. there is clear evidence of maternal transmission, although disagreement on the source of the bse agent remains. the current theories link the origin of bse to common scrapie in sheep. twenty different strains of the scrapie agent have been isolated from sheep. a search of the literature indicates two distinct clinical syndromes in sheep, both of which have been ...200111444100
[prionoses--neurodegenerative diseases caused by prions, offectious proteinaceous molecules].prionoses are a group of human and animal neurodegenerative diseases caused by prions, infectious pathogens that differ from bacteria, fungi, parasites, viroids, and viruses. despite intensive searches over the past three decades, no nucleic acid has been found within prions and considerable experimental data argue that prions are composed exclusively of proteins (glycoproteins). normal prion protein (prpc) is encoded by a gene present in all nuclear cells of humans and other mammals but is cons ...19989810774
origin and implications of bovine spongiform encephalopathy.all spongiform encephalopathies in animals, including humans, are slow developing infectious diseases. the current working theory links the origin of bovine spongiform encephalopathy (bse) to the feeding of cattle with meat and bone meal prepared from scrapie-infected sheep remains. recycling of cattle meat and bones (mbm) essentially resulted in the selection of a single strain from the "wild type", a mixture of 20 strains. the bse agent is easily transmitted through ingestion, with some eviden ...19968618936
recently described scrapie-like encephalopathies of animals: case definitions.since 1986, naturally occurring scrapie-like encephalopathies have been described in the united kingdom in domestic cattle, in five species of captive exotic bovids and in domestic cats. the disease in domestic cattle, bovine spongiform encephalopathy, has been characterised by all currently available diagnostic criteria as a transmissible spongiform encephalopathy or 'prion' disease, and has been shown to have a dietary origin. the pathology in the other species is also entirely consistent with ...19921410804
bovine spongiform encephalopathy (bse)--infectious, contagious, zoonotic or production disease?in 1986, a new progressive neurological condition similar to scrapie of sheep and goats was recognised in cattle in the united kingdom (uk), and was named bovine spongiform encephalopathy (bse). there is an ongoing discussion whether bse should be classified as infectious, contagious, or zoonotic, and if it fits the definition of a production disease. the objective of this work is to briefly describe the main characteristics of transmissible spongiform encephalopathies (tse), to review the epide ...200315259778
transmissions to mice indicate that 'new variant' cjd is caused by the bse agent.there are many strains of the agents that cause transmissible spongiform encephalopathies (tses) or 'prion' diseases. these strains are distinguishable by their disease characteristics in experimentally infected animals, in particular the incubation periods and neuropathology they produce in panels of inbred mouse strains. we have shown that the strain of agent from cattle affected by bovine spongiform encephalopathy (bse) produces a characteristic pattern of disease in mice that is retained aft ...19979333239
bse: spongiform encephalopathy found in cat. 19902333092
other animal prion diseases.in addition to bovine spongiform encephalopathy (bse) of cattle and scrapie of sheep and goats, a few other animal prion diseases have been reported. these include feline spongiform encephalopathy of zoological and domestic cats (fse) and transmissible spongiform encephalopathy (tse) of zoological ruminants and non-human primates, as well as chronic wasting disease of deer and elk (cwd) and transmissible mink encephalopathy of farmed mink (tme). the origins of tse in cats, zoo bovids, and non-hu ...200314522860
the emergence of bovine spongiform encephalopathy and related diseases.since 1986, approximately 170,000 cases of bovine spongiform encephalopathy (bse) have occurred among approximately one million animals infected by contaminated feed in the united kingdom. a ruminant feed ban in 1988 resulted in the rapid decline of the epidemic. transmissible spongiform encephalopathies due to agents indistinguishable from bse have appeared in small numbers of exotic zoo animals; a small outbreak among domestic cats is declining. creutzfeldt-jakob disease (cjd) has been intensi ...19989716952
historical overview of prion diseases: a view from afar.the transmissible spongiform encephalopathies (tses), or prion diseases, are a group of neurodegenerative disorders which include kuru, creutzfeldt-jakob disease (cjd), gerstmann-sträussler-scheinker (gss) syndrome, and fatal familial insomnia in men, natural scrapie in sheep, goats and mufflons, transmissible mink encephalopathy in ranch-reared mink, chronic wasting disease of mule deer and elk, bovine spongiform encephalopathy or "mad cow disease" and its analogues in several exotic species of ...201222505359
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