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a sero-epidemiological survey for bunyaviridae and certain other arboviruses in pakistan.complement fixation test reactions to the following viruses were studied in 372 samples (157 rodents, 172 domestic animals, 43 persons) from pakistan: bunyaviridae, phlebovirus: phlebotomus fever sicilian (pfs), phlebotomus fever naples (pfn), karimabad (kar), salehabad (sal); nairovirus: crimean-congo haemorrhagic fever (cchf), hazara (haz), dera ghazi khan (dgk), dhori (dho); uukuvirus: manawa (mwa); "possible members": bakau (bak), bhanja (bha). reoviridae, orbivirus: wad medani (wm). unclass ...19836415873
human mxa protein inhibits tick-borne thogoto virus but not dhori virus.thogoto and dhori viruses are tick-borne orthomyxoviruses infecting humans and livestock in africa, asia, and europe. here, we show that human mxa protein is an efficient inhibitor of thogoto virus but is inactive against dhori virus. when expressed in the cytoplasm of stably transfected cell lines, mxa protein interfered with the accumulation of thogoto viral rna and proteins. likewise, mxa(r645), a mutant mxa protein known to be active against influenza virus but inactive against vesicular sto ...19957745744
genetic analysis of crimean-congo hemorrhagic fever virus in iran.crimean-congo hemorrhagic fever (cchf) is a potentially fatal disease caused by a tick-borne virus in the family bunyavridae. the disease occurs in parts of africa, asia, middle east, and eastern europe. during recent years, an increasing number of human cchf cases have been diagnosed in iran, but very little information is available on the prevalence and genetic diversity of cchfv in iran. in the present study, cchf virus (cchfv) isolates from nine iranian patients infected during 2002 were exa ...200415170636
host and viral traits predict zoonotic spillover from mammals.the majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, hiv, ebola and sars). understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals for pandemic surveillance programs. however, few analytical tools exist to identify which host species are likely to harbour the next human virus, or which viruses can cross species ...201728636590
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