Publications

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isolation of a putative fimbrial adhesin from bordetella pertussis and the identification of its gene.we report the purification of a minor bordetella pertussis fimbrial subunit, designated fimd, and the identification of its gene (fimd). fimd could be purified from the bulk of major fimbrial subunits by exploiting the fact that major subunit-subunit interactions are more stable in the presence of sds than minor-major subunit interactions. to locate the gene for fimd, internal peptides of fimd were generated, purified and sequenced. subsequently, an oligonucleotide probe, based on the primary se ...19938105363
bhur, a virulence-associated outer membrane protein of bordetella avium, is required for the acquisition of iron from heme and hemoproteins.iron (fe) is an essential element for most organisms which must be obtained from the local environment. in the case of pathogenic bacteria, this fundamental element must be acquired from the fluids and tissues of the infected host. a variety of systems have evolved in bacteria for efficient acquisition of host-bound fe. the gram-negative bacterium bordetella avium, upon colonization of the avian upper respiratory tract, produces a disease in birds that has striking similarity to whooping cough, ...200212228263
unexpected similarities between bordetella avium and other pathogenic bordetellae.bordetella avium causes an upper respiratory tract disease (bordetellosis) in avian species. commercially raised turkeys are particularly susceptible. like other pathogenic members of the genus bordetella (b. pertussis and b. bronchiseptica) that infect mammals, b. avium binds preferentially to ciliated tracheal epithelial cells and produces similar signs of disease. these similarities prompted us to study bordetellosis in turkeys as a possible nonmammalian model for whooping cough, the exclusiv ...200312704133
a uk clinical isolate of bordetella hinzii from a patient with myelodysplastic syndrome.what is believed to be the first clinical isolate of bordetella hinzii in the uk, from a patient with myelodysplastic syndrome, is described. this patient had no known avian exposure, and the source of the organism remains unknown. it appears that the underlying immune deficiency of the patient increased the susceptibility to opportunistic infection with this organism. human infection with b. hinzii is rare and this species is difficult to differentiate from bordetella avium by routine phenotypi ...200718033844
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