quantities of infectious virus and viral rna recovered from sheep and cattle experimentally infected with foot-and-mouth disease virus o uk 2001.the profiles of virus production and excretion have been established for sheep experimentally infected with the uk 2001 strain of foot-and-mouth disease (fmd) virus by inoculation and by direct and intensive contact. virus replicated rapidly in the inoculated sheep, from which a peak infectivity of airborne virus of 10(4.3) tcid(50) per sheep per 24 h was recovered. around 24 h later, contact-infected sheep excreted airborne virus maximally. similar amounts of airborne virus were recovered from ...200212124455
procedures for preventing transmission of foot-and-mouth disease virus (o/taw/97) by people.the aim of this study was to determine personal hygiene protocols and animal avoidance periods needed to prevent transmission of fmdv (o/taw/97). forty-six, 9-week-old barrows free of fmdv were randomly allocated to five treatment groups and a control group. investigators contacted and sampled fmdv-inoculated pigs for approximately 40 min and then contacted and sampled sentinel pigs after using no biosecurity procedures, washing hands and donning clean outerwear, or showering and donning clean o ...200415504585
development of an epitope-blocking-enzyme-linked immunosorbent assay to differentiate between animals infected with and vaccinated against foot-and-mouth disease epitope-blocking elisa (eb-elisa) was developed to distinguish animals infected with foot-and-mouth-disease (fmdv) from those immunized with commercial vaccines. the assay used monoclonal antibodies to target the 3b core repeat motif (qkplk) and purified recombinant 3ab proteins from the major b cell line epitopes of fmdv. sera from uninfected and regularly vaccinated cattle, pigs, goats, and sheep (raised in fmdv free areas) were screened to evaluate the specificity of the eb-elisa. the spec ...200717336400
foot-and-mouth disease virus (o/ukg/2001) is poorly transmitted between sheep by the airborne route.foot-and-mouth disease virus (fmdv) can be spread by the airborne route and therefore atmospheric dispersion models have been developed to predict where the virus might spread during a disease outbreak. airborne transmission between sheep of the fmdv strain involved in the outbreak in europe in 2001 (o/ukg/2001) was studied experimentally. recipient animals were exposed to two donor sheep excreting virus for 2, 4, 6, 8 or 24 h. although fmdv was detected in air samples collected during challenge ...200817629524
myocarditis associated with foot-and-mouth disease virus type o in lambs.the present study describes the pathogenetic mechanisms of myocarditis in 9 lambs that died in a foot-and-mouth disease outbreak in samsun, turkey. in all the heart samples tested, elisa and sequencing for phylogenetic analyses showed that the virus, namely o/tur/samsun/05, was associated with the panasia pandemic strain of foot-and-mouth disease virus (fmdv) type o. the lambs had myocardial lesions but no typical vesicular lesions. in situ reverse transcription showed that many cardiomyocytes a ...200717846231
influence of exposure intensity on the efficiency and speed of transmission of foot-and-mouth disease.foot-and-mouth disease virus (fmdv) can be spread by direct animal-to-animal contact, indirect contact facilitated by contaminated materials or by airborne spread. the rate of spread and the incubation period, as well as the severity of disease, depends on many variables including the dose received, the route of introduction, the virus strain, the animal species and the conditions under which the animals are kept. quantitative data related to these variables are needed if model predictions are t ...200919215941
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