| host and viral traits predict zoonotic spillover from mammals. | the majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, hiv, ebola and sars). understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals for pandemic surveillance programs. however, few analytical tools exist to identify which host species are likely to harbour the next human virus, or which viruses can cross species ... | 2017 | 28636590 |
| structural and evolutionary analysis of an orangutan foamy virus. | the full-length proviral genome of a foamy virus infecting a bornean orangutan was amplified, and its sequence was analyzed. although the genome showed a clear resemblance to other published foamy virus genomes from apes and monkeys, phylogenetic analysis revealed that simian foamy virus sfvora was evolutionarily equidistant from foamy viruses from other hominoids and from those from old world monkeys. this finding suggests an independent evolution within its host over a long period of time. | 2003 | 12857929 |
| screening for simian foamy virus infection by using a combined antigen western blot assay: evidence for a wide distribution among old world primates and identification of four new divergent viruses. | simian foamy viruses (sfvs) belong to a genetically and antigenically diverse class of retroviruses that naturally infect a wide range of nonhuman primates (nhps) and can also be transmitted to humans occupationally exposed to nhps. current serologic detection of sfv infection requires separate western blot (wb) testing by using two different sfv antigens [sfv(agm) (african green monkey) and sfv(cpz) (chimpanzee)]. however, this method is labor intensive and validation is limited to only small n ... | 2003 | 12758172 |