Publications

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herpesviral diseases affecting reproduction in the horse. 19806262988
subclinical infection and periodic shedding of equid herpesvirus 3.the temporary disruption of reproductive activities due to equine coital exanthema (ece), caused by equid herpesvirus 3 (ehv-3), at thoroughbred breeding facilities and embryo transfer centres, has an appreciable economic impact. the aim of the present study was to estimate the prevalence of excretion of ehv-3 in mares without clinical symptoms under field conditions and the re-excretion patterns of the virus in two seropositive (presumably latently infected) mares maintained in isolation for 11 ...201020494427
infectious skin diseases of horses. 19846330957
molecular pathogenesis of equine coital exanthema: restriction endonuclease digestions of ehv-3 dna and indications of a unique xbai cleavage site.equine herpesvirus type 3 (ehv-3) dna, isolated from purified virions of the large-plaque strain, was digested with the restriction endonucleases xbai, bg/ii, ecori, and hindiii. several lines of evidence indicated that the dna extracted from purified virions was composed of long (l) and short (s) components and was present as two isomeric forms, p and is. the evidence included: (i) after electrophoresis on agarose gels, the summed molecular weights of the digestion products exceeded that expect ...19852985521
antiretroviral activity of synthetic hypericin and related analogs.hypericin and pseudohypericin are naturally occurring polycyclic quinones which have recently been shown to inhibit the infectivity of several retroviruses, including human immunodeficiency virus. to better understand the antiviral mechanisms of these compounds, hypericin and a series of analogous quinones were synthesized and tested for anti-retroviral activity against equine infectious anemia virus (eiav). treatment of eiav-infected cells with hypericin reduced the production of infectious vir ...19901699534
molecular pathogenesis of equine coital exanthema (ece): temperature sensitivity (ts) and restriction endonuclease (re) fragment profiles of several field isolates.examination of six field isolates of equine herpesvirus 3, the causative agent of equine coital exanthema, indicates that all were temperature sensitive (ts) at the body temperature, 39 degrees c, of their host (equine asinus and callabus) when grown in cell culture. the isolates were characterized by fingerprint analysis with the restriction endonucleases xbai, ecori, bamhi and hind iii to establish possible epidemiologic relatedness. three of the six isolates may be considered related. variati ...19873028334
isolation of equine coital exanthema virus (equine herpesvirus 3) from the nostril of a foal.the virus causing equine coital exanthema (equine herpesvirus 3) was isolated from a lesion on the nostril of a 2-month-old foal. one week after the mare had returned from a stallion station, vesicular lesions developed on her vulva. they were diagnosed clinically as coital exanthema, and 5 days later a lesion developed on the nostril of her foal. this case is an example of horse-to-horse transmission of coital exanthema virus without coitus. a laboratory diagnosis is necessary to differentiate ...19852997094
temperature sensitivity of equine herpesvirus isolates: a brief review.this article reviews the findings on temperature sensitivity of equine herpesvirus isolates with an emphasis on equine herpesvirus 3, etiological agent of equine coital exanthema. the hypothesis is presented that the relative apathogenic nature of this herpesvirus may be an indirect result of its inability to synthesize and/or process glycoproteins needed by the virus to produce infectious virions at the normal body temperature of its natural host. it is suggested that equine herpesvirus 3 is th ...19901369251
replication of equine herpesvirus type 1 and type 3: resistance to hydroxyurea and thymidine.the replication of equine herpesvirus type 1 (ehv-1) and type 3 (ehv-3) was unimpeded in three different cell types-equine epithelial cells, equine fibroblasts, and mouse fibroblasts-which had been blocked in their capacity to synthesize host dna by 2.5 mm hydroxyurea (hu) or 2 mm thymidine (tdr). the rate of dna synthesis in uninfected or equine herpesvirus-infected cells in the presence of hu or tdr was measured by pulse-labeling cell samples with a labeled dna precursor at different times aft ...1978563855
antibodies against equine herpesviruses in free-ranging mountain zebras from namibia.twenty-one blood samples of free-ranging mountain zebras (equus zebra) from namibia were tested for equine herpesvirus (ehv-1, -2, -3, -4) specific antibodies by immunofluorescence assay (ifa) and neutralization test (nt). additionally, type-specific nested polymerase chain reactions (nested pcr) were employed for detection of ehv-1, -2 and -4 dna. equine herpesvirus-1 antibodies were detected by ifa in all zebras, while only seven serum samples contained ehv-4 ifa antibodies. sera with high ifa ...19979391966
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