| some physical and growth characteristics of a canine adenovirus isolated from dogs with laryngotracheitis. | | 1966 | 5951707 |
| occurrence of canine adenovirus antibodies and non-specific inhibitors of haemagglutination in the sera of diverse animal species. | | 1973 | 4357493 |
| identification of a canine adenovirus (infectious canine hepatitis virus) inhibitor in dog liver extracts as arginase. | extracts of canine liver inhibited growth of infectious canine hepatitis (ich) virus, a canine adenovirus. purified extracts from mammalian, but not avian, liver tissue contained the inhibitor, and evidence is presented that the inhibitory factor is the enzyme arginase (arginine ureohydrolase). this study further emphasized the need for arginine in adenovirus growth and may explain some of the difficulties in isolating small amounts of ich virus from suspensions of liver. | 1972 | 4344396 |
| diagnosis of infectious canine hepatitis virus (cav-1) infection in puppies with encephalopathy. | nine weaned labrador retriever puppies from a litter of 11 were presented with signs of acute central nervous system (cns) disease that included ataxia and blindness. all puppies died. gross examination of tissues from 2 puppies revealed regionally diffuse hemorrhages in the brain stem and swollen hemorrhagic lymph nodes. light microscopic examination of hematoxylin and eosin-stained tissues showed numerous large, basophilic intranuclear inclusion bodies within cns vascular endothelium and occas ... | 2005 | 15690952 |
| characterization of a canine adenovirus hemagglutinin. | | 1971 | 4323345 |
| cloning, physical mapping and cross-hybridization of the canine adenovirus types 1 and 2 genomes. | cloned hindiii fragments of the type 1 and type 2 canine adenovirus (canad) genomes were mapped with respect to the bamhi, ecori, hincii, paer7 and psti restriction endonuclease cleavage sites. considering the large differences found between the canad-1 and canad-2 dna molecules, in terms of number and location of restriction sites, cross-hybridization experiments were performed. homologous dna sequences were located on the canad-1 and canad-2 physical maps. both viruses are genetically related ... | 1987 | 3440519 |
| bronchiolitis obliterans and pneumonia induced in young dogs by experimental adenovirus infection. | young beagle dogs were experimentally inoculated with canine adenovirus type 2 and studied by virologic, histologic, immunoperoxidase, and ultrastructural methods from 1 to 26 days after inoculation. virus was recovered from lungs at 2, 3, 5, and 8 days after inoculation. virions and viral antigen were demonstrated by ultrastructural and immunoperoxidase techniques in nonciliated bronchiolar epithelial cells and mucous cells in bronchioles, bronchi, and trachea as well as in bronchial and trache ... | 1985 | 2990219 |
| vaccine-associated canine distemper infection in a litter of african hunting dogs (lycaon pictus). | four, 57 days old, african hunting dog puppies (lycaon pictus) from one litter died within three weeks following vaccination with modified-live canine distemper virus (cdv) and killed canine adenovirus type 1, canine parvovirus and leptospira icterohemorrhagiae and canicola. 18 days post vaccination, the animals developed neurologic disease characterized by episodes of grand mal seizures and circling. macroscopic, histological and immunohistochemical studies revealed acute systemic cdv infection ... | 1990 | 2385981 |
| corneal endothelium in viral induced anterior uveitis. ultrastructural changes following canine adenovirus type 1 infection. | dogs inoculated intravenously with attenuated canine adenovirus type 1 developed anterior segment inflammation and corneal edema. during the stage of mild anterior uveitis, virus was isolated from the aquious fluid, and by electron microscopy, viral replication was found to occur in corneal endothelial cells. later, at the stage of severe anterior uveitis with corneal edema, virus was not isolated from the aqueous fluid and cells containing intranuclear (replicating) virus were not found. at thi ... | 1975 | 1138688 |
| use of canine adenovirus type 2 vaccine to control kennel cough syndrome. | | 1979 | 223268 |
| canine adenovirus type 2-induced immunity to two canine adenoviruses in pups with maternal antibody. | twenty-four beagle pups with high levels of maternal antibody to canine adenovirus type 1 (cav-1) and canine adenovirus type 2 (cav-2) were oronasally inoculated with cav-2 at 4 weeks of age. the cav-2 was isolated from pharyngeal swabs on postinoculation days 2 through 6. in spite of the infection, maternal antibody continued to decrease for 4 to 8 postinoculation weeks, and then homologous cav-2 neutralizing antibody and, to a lesser extent, cav-1 neutralizing antibody began to increase. when ... | 1975 | 168797 |
| clinical and microbiologic characterization of hemorrhagic pneumonia due to extraintestinal pathogenic escherichia coli in four young dogs. | over a 21-month period, three beagle dogs and one mixed-breed dog at our facility developed fatal pneumonia. the four dogs, all purpose bred, came from three vendors and had received the standard canine vaccines prior to shipment. in each instance, the affected dog had been shipped to our facility within the past 10 days. three cases presented as a peracute clinical syndrome, and all had gross and microscopic findings consistent with hemorrhagic pneumonia. escherichia coli was isolated from the ... | 2003 | 14727816 |
| a single immunization with a recombinant canine adenovirus expressing the rabies virus g protein confers protective immunity against rabies in mice. | rabies vaccines based on live attenuated rabies viruses or recombinant pox viruses expressing the rabies virus (rv) glycoprotein (g) hold the greatest promise of safety and efficacy, particularly for oral immunization of wildlife. however, while these vaccines induce protective immunity in foxes, they are less effective in other animals, and safety concerns have been raised for some of these vaccines. because canine adenovirus 2 (cav2) is licensed for use as a live vaccine for dogs and has an ex ... | 2006 | 16938327 |
| duration of serologic response to five viral antigens in dogs. | to determine whether vaccinated dogs either remained seropositive or responded serologically to revaccination for 5 key viral antigens after extended periods since their last vaccination. | 2004 | 14710876 |
| vaccination of puppies born to immune dams with a canine adenovirus-based vaccine protects against a canine distemper virus challenge. | none of the currently available distemper vaccines provides a satisfactory solution for the immunization of very young carnivores in the face of maternal-derived immunity. since mucosal immunization with replication-competent adenovirus-based vaccines has been proven effective in the face of passive immunity against the vector, it has the potential to provide a solution for the vaccination of young puppies born to canine distemper virus (cdv)-immune dams. we report the engineering and the charac ... | 2002 | 12297394 |
| glomerulonephritis associated with simultaneous canine adenovirus-1 and dirofilaria immitis infection in a dog. | this article describes a case of glomerulonephritis and immunocomplex (igm, igg and c3c) deposition in the mesangium and basement membranes of a 2-year-old dog with canine viral hepatitis and dirofilariasis. the deposits observed in the mesangium were in the vicinity of cells with viral replication. however, no clear relationship was found between viral replication and the deposition of immunocomplexes in the glomerular capillary basement membranes, which may be the reason why these deposits hav ... | 2002 | 12121044 |
| serologic survey of selected viral agents in recently captured wild north american river otters (lontra canadensis). | blood samples were collected from 64 wild north american river otters (lontra [lutra] canadensis) from northern and eastern new york state and analyzed for serologic evidence of exposure to selected viral agents during a 1995 1996 translocation program. no clinical signs of disease nor lesions suggestive of prior viral exposure were seen. titers were detected for antibodies against canine distemper virus, canine herpesvirus-1, and canine parvovirus-2 but not for antibodies against canine adenovi ... | 2000 | 10982127 |
| nedocromil sodium inhibits canine adenovirus bronchiolitis in beagle puppies. | nedocromil sodium is a nonsteroidal anti-inflammatory drug used to control asthmatic attacks. our hypothesis is that nedocromil sodium inhibits virus-induced airway inflammation, a common trigger of asthma. we nebulized nedocromil sodium into beagle dogs (n = 10, mean +/- sem ages: 149 +/- 13 days) before and after inoculation with canine adenovirus type 2 (cav2). control dogs (n = 10) received saline aerosols and were either infected with cav2 (sal/cav2, n = 7, mean +/- sem ages: 140 +/- 11 day ... | 2000 | 10805150 |
| three-year serologic immunity against canine parvovirus type 2 and canine adenovirus type 2 in dogs vaccinated with a canine combination vaccine. | a group of client-owned dogs and a group of dogs at a commercial kennel were evaluated for duration of antibody responses against canine parvovirus type 2 (cpv-2) and canine adenovirus type 1 (cav-1) after receiving a combination vaccine containing recombinant canarypox-vectored canine distemper virus (cdv) and modified-live cpv-2, cav-2, and canine parainfluenza virus, with (c6) or without (c4) two serovars of leptospira (recombitek c4 or c6, merial). duration of antibody, which correlates with ... | 2007 | 18183549 |
| survey on viral pathogens in wild red foxes (vulpes vulpes) in germany with emphasis on parvoviruses and analysis of a dna sequence from a red fox parvovirus. | the seroprevalence of canine parvovirus (cpv), canine distemper virus (cdv), canine adenovirus (cav) and canine herpesvirus (chv) infections in red foxes (vulpes vulpes) was determined in fox sera collected between 1991 and 1995. a total of 500 sera were selected and the seroprevalences were estimated to be 13% (65 of 500 sera) for cpv, 4.4% (17 of 383 sera) for cdv, 35% (17 of 485 sera) for cav, and 0.4% (2 of 485 sera) for chv, respectively. no statistically significant differences were observ ... | 1998 | 9825797 |
| seroepidemiological survey of sympatric domestic and wild dogs (lycaon pictus) in tsumkwe district, north-eastern namibia. | disease is a potential threat to many endangered populations and may originate from sympatric domestic species. this paper describes a cross-sectional serological survey of canine pathogens carried out in domestic (n = 70) and wild dogs (lycoan pictus) (n = 6), in tsumkwe district, northeastern namibia. evidence of past exposure to canine distemper virus, canine adenovirus and parainfluenza virus was evident in both wild and domestic dogs with this, the first, documented exposure of free-living ... | 1997 | 9551484 |
| fractal analysis of lung alveoli during the acute phase vs. repair phase of an adenoviral infection in canines. | acute viral respiratory infections are commonly associated with alterations in lung growth. recently, fractal techniques have been demonstrated to show changes in alveolar perimeter after canine adenovirus type 2 (cav2) infection in a beagle puppy model. in the present study, we investigated whether the fractal dimension (df) of the alveolar perimeter was changed in the acute phase (2-3 weeks after inoculation, 131d cav2 group) or during the recovery phase (approximately 22 weeks after inoculati ... | 1997 | 9144835 |
| serologic survey of giant pandas (ailuropoda melanoleuca), and domestic dogs and cats in the wolong reserve, china. | sera from captive and recently rescued giant pandas (ailuropoda melanoleuca) in the wolong reserve, china, were examined by serum neutralization or hemagglutination inhibition for antibodies to canine distemper virus (cdv), canine coronavirus (ccv), canine herpesvirus (chv), pseudorabies virus (prv), canine adenovirus type 2 (cav), and canine parvovirus (cpv). serum samples from village domestic dogs and cats, which run free throughout the reserve also were examined. antibodies against cpv were ... | 1994 | 8151830 |
| ultrastructural study of unidentified inclusions in the cornea and iridocorneal angle of dogs with pannus. | the corneas and/or the iridocorneal angles of 13 dogs were examined morphologically by use of transmission electron microscopy. virologic identification techniques also were used for tissue from 2 dogs. four dogs had clinical signs of chronic superficial keratitis or pannus, 9 dogs had normal eyes. in the tissue from 7 dogs (4 german shepherd dogs with chronic superficial keratitis; 2 german shepherd dogs and 1 mixed-breed dog with normal eyes) we found unusual cytoplasmic inclusions. inclusions ... | 1995 | 7653888 |
| a modified live canine parvovirus vaccine. ii. immune response. | the safety and efficacy of an attenuated canine parvovirus (a-cpv) vaccine was evaluated in both experimental and in field dogs. after parenteral vaccination, seronegative dogs developed hemagglutination-inhibition (hi) antibody titers as early as postvaccination (pv) day 2. maximal titers occurred within 1 week. immunity was associated with the persistence of hi antibody titers (titers greater than 80) that endured at least 2 years. immune dogs challenged with virulent cpv did not shed virus in ... | 1983 | 6337780 |
| parasitology and serology of free-ranging coyotes (canis latrans) in north carolina, usa. | coyotes (canis latrans) have expanded recently into the eastern us and can serve as a source of pathogens to domestic dogs (canis lupus familiaris), livestock, and humans. we examined free-ranging coyotes from central north carolina, us, for selected parasites and prevalence of antibodies against viral and bacterial agents. we detected ticks on most (81%) coyotes, with amblyomma americanum detected on 83% of those with ticks. fifteen (47%) coyotes were positive for heartworms (dirofilaria immiti ... | 2015 | 25984773 |
| exposure to selected pathogens in to selected pathogens in geoffroy's cats and domestic carnivores from central argentina. | wild carnivores share a high percentage of parasites and viruses with closely related domestic carnivores. because of increased overlap and potential contact with domestic species, we conducted a retrospective serosurvey for 11 common carnivore pathogens in 40 geoffroy's cats (leopardus geoffroyi) sampled between 2000 and 2008 within or near two protected areas in central argentina (lihué calel national park, la pampa, and campos del tuyú national park, buenos aires), as well as five domestic ca ... | 2012 | 23060491 |
| unambiguous typing of canine adenovirus isolates by deoxyribonucleic acid restriction-endonuclease analysis. | viral deoxyribonucleic acid extracted from a limited number of cells infected with canine adenovirus type 1 or type 2 was cleaved with several restriction endonucleases. agarose gel electrophoresis of the limit digests showed stable differences between the canine adenovirus type 1 and type 2 cleavage patterns. rapid and accurate typing of large numbers of clinical isolates may thus be done by deoxyribonucleic acid restriction-endonuclease analysis. | 1983 | 6321002 |
| immunoperoxidase study of canine distemper virus pneumonia. | forty-two cases of canine pneumonia were examined for the presence of canine distemper virus. for that purpose canine distemper virus inclusion bodies were located. the histopathological lesions were related to the presence of canine distemper antigen, as demonstrated with an immunoperoxidase technique. this technique was more sensitive for detecting canine distemper infection in lung tissue than was the study of inclusion bodies. attention was also paid to combined infection with canine adenovi ... | 1983 | 6304834 |
| intranasal vaccine trial for canine infectious tracheobronchitis (kennel cough). | two field trials were conducted during periods of endemic (summer) and epizootic (winter) canine infectious tracheobronchitis activity to evaluate the efficacy of three intranasal vaccines in a closed commercial beagle breeding kennel. a trivalent vaccine containing bordetella bronchiseptica, canine parainfluenza, and canine adenovirus-2 was administered at 3 weeks of age. the vaccine was 71.2% and 81.8% effective in decreasing the incidence of coughing during the winter and summer trials, respe ... | 1981 | 6273648 |
| canine adenovirus-induced ocular lesions in the afghan hound. | a series of referred cases of cav-1-induced ocular disease suggested increased susceptibility of the afghan hound. of a litter of afghan hound puppies inoculated with a commercial vaccine containing attenuated cav-1, three developed corneal edema and the litter as a whole showed marked febrile and serological responses to the virus. under experimental conditions afghan hounds inoculated with cav-1 at two levels of attenuation showed more profound clinical responses than beagles receiving similar ... | 1981 | 6262015 |
| canine distemper and related diseases: report of a severe outbreak in a kennel. | an outbreak of canine distemper in a kennel of german shepherds in the province of bari is reported. six 42-day-old pups developed typical signs of canine distemper (fever, conjunctivitis, respiratory distress and enteritis) and died within 7-10 days. neurological symptoms were observed only in one pup. four additional pups, which had shown no sign of illness, were separated and vaccinated, but two of these developed a severe, fatal nervous form 15 days later. post-mortem examination, carried ou ... | 2004 | 15164629 |
| parasitology, virology, and serology of free-ranging coyotes (canis latrans) from central georgia, usa. | we examined 31 free-ranging coyotes (canis latrans) from central georgia, usa, for select parasites and viral agents. sixteen coyotes had adult heartworms (dirofilaria immitis). serum samples from 27 animals revealed antibodies against canine parvovirus (100%), canine distemper virus (48%), canine adenovirus (37%), and trypanosoma cruzi (7%); none were detected against leishmania spp. twenty-two of 24 (92%) coyotes were positive for toxoplasma gondii. real-time pcr of feces revealed 32% of coyot ... | 2014 | 25098300 |
| three-year duration of immunity in dogs following vaccination against canine adenovirus type-1, canine parvovirus, and canine distemper virus. | a challenge-of-immunity study was conducted to demonstrate immunity in dogs 3 years after their second vaccination with a new multivalent, modified-live vaccine containing canine adenovirus type 2 (cav-2), canine parvovirus (cpv), and canine distemper virus (cdv). twenty-three seronegative pups were vaccinated at 7 and 11 weeks of age. eighteen seronegative pups, randomized into groups of six dogs, served as challenge controls. dogs were kept in strict isolation for 3 years following the vaccina ... | 2005 | 15906266 |
| isolation and identification of canine adenovirus type-2 from the upper respiratory tract of a dog. | to report on the isolation and identification of canine adenovirus type-2 (cav-2) from a greyhound dog with tracheitis/tonsillitis. | 1998 | 16032028 |
| immunohistochemical detection of antigens of distemper, adenovirus and parainfluenza viruses in domestic dogs with pneumonia. | the lungs of 35 dogs that died in mexico from acute or subacute pneumonia were examined immunohistochemically for canine distemper virus (cdv), canine adenovirus (cav) and canine parainfluenza virus (cpiv), to determine their frequency and occurrence and possible associations. cdv was identified in 27 (77%) cases, cav in 20 (57%) and cpiv in 18 (51%). the most frequent dual association was that between cdv and cpiv (five cases; 14%). all three viruses, however, were identified in the same lung i ... | 2005 | 16202422 |
| cloning and expression of canine interferon-alpha genes in escherichia coli. | we cloned five new subtypes of cdna encoding canine interferon-alpha (caifn-alpha) from a canine epithelial cell line. caifn-alphas were divided into two groups by amino acid sequences and a molecular phylogenic tree. two subtypes of them were expressed in escherichia coli, and ifn proteins were purified. recombinant caifn-alphas were highly species-specific and showed antiviral activity against vesicular stomatitis new jersey virus and canine adenovirus-1 , but not against canine herpesvirus-1. | 2005 | 16276065 |
| host and viral traits predict zoonotic spillover from mammals. | the majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, hiv, ebola and sars). understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals for pandemic surveillance programs. however, few analytical tools exist to identify which host species are likely to harbour the next human virus, or which viruses can cross species ... | 2017 | 28636590 |
| canine adenovirus vectors for lung-directed gene transfer: efficacy, immune response, and duration of transgene expression using helper-dependent vectors. | a major hurdle to the successful clinical use of some viral vectors relates to the innate, adaptive, and memory immune responses that limit the efficiency and duration of transgene expression. some of these drawbacks may be circumvented by using vectors derived from nonhuman viruses such as canine adenovirus type 2 (cav-2). here, we evaluated the potential of cav-2 vectors for gene transfer to the respiratory tract. we found that cav-2 transduction was efficient in vivo in the mouse respiratory ... | 2006 | 16415025 |
| canine adenovirus type 2 infection in four puppies with neurological signs. | four nine- to 11-week-old puppies developed respiratory and neurological signs due to an infection with canine adenovirus type 2 (cav-2); three of these were euthanased. they had moderate, diffuse pneumonia but there were no histological abnormalities in the central nervous system. adenovirus-specific nucleic acid was detected by pcr in samples of lung and brain and the amplified product was 99.8 per cent homologous with the cav-2 reference strain toronto a26/61. the positive pcr result was conf ... | 2006 | 16428663 |
| compatibility of a bivalent modified-live vaccine against bordetella bronchiseptica and cpiv, and a trivalent modified-live vaccine against cpv, cdv and cav-2. | eight puppies (group 1) were vaccinated once with a bivalent modified-live vaccine against infectious tracheobronchitis by the intranasal route and at the same time with an injectable trivalent vaccine against canine parvovirus, canine distemper virus and canine adenovirus; a second group of eight puppies (group 2) was vaccinated only with the intranasal bivalent vaccine, and a further eight puppies (group 3) were vaccinated only with the injectable trivalent vaccine. three weeks later they were ... | 2007 | 17220520 |
| canine respiratory viruses. | acute contagious respiratory disease (kennel cough) is commonly described in dogs worldwide. the disease appears to be multifactorial and a number of viral and bacterial pathogens have been reported as potential aetiological agents, including canine parainfluenza virus, canine adenovirus and bordetella bronchiseptica, as well as mycoplasmas, streptococcus equi subsp. zooepidemicus, canine herpesvirus and reovirus-1,-2 and -3. enhancement of pathogenicity by multiple infections can result in more ... | 2007 | 17296161 |
| exposure of free-ranging maned wolves (chrysocyon brachyurus) to infectious and parasitic disease agents in the noël kempff mercado national park, bolivia. | maned wolves (chrysocyon brachyurus) are neotropic mammals, listed as a cites appendix ii species, with a distribution south of the amazon forest from bolivia, through northern argentina and paraguay and into eastern brazil and northern uruguay. primary threats to the survival of free-ranging maned wolves include habitat loss, road kills, and shooting by farmers. an additional threat to the conservation of maned wolves is the risk of morbidity and mortality due to infectious and parasitic diseas ... | 2005 | 17323558 |
| combined distemper-adenoviral pneumonia in a dog. | a 3 1/2-month-old pug with oculonasal discharge and seizures was submitted for postmortem examination. grossly, the lungs had cranioventral consolidation, and microscopically, 2 distinct types of inclusion bodies compatible with canine distemper virus and canine adenovirus type 2. presence of both viruses was confirmed via immunohistochemical staining. | 2007 | 17616064 |
| oral vaccination of dogs (canis familiaris) with baits containing the recombinant rabies-canine adenovirus type-2 vaccine confers long-lasting immunity against rabies. | rabies is a reemerging and fatal infectious disease in asia mainly caused by exposure to rabid dogs. prevention of dog rabies would be the most effective way to stop rabies transmission to humans. however, vaccinating stray dogs in urban and rural areas using conventional vaccines is always difficult and is not cost-effective for use in most areas including china. further to previous studies from our laboratory, we developed a bait containing the recombinant rabies vaccine and performed a non-pa ... | 2008 | 18083277 |
| development of recombinant canine adenovirus type-2 expressing the gn glycoprotein of seoul virus. | seoul virus glycoprotein gn is a major structural protein and candidate antigen of hantavirus that induces a highly immunogenic response for hantavirus vaccine. in this study, a replication-competent recombinant canine adenovirus type-2 expressing gn was constructed by the in vitro ligation method. the gn expression cassette, including the human cytomegalovirus (hcmv) promoter/enhancer and the sv40 early mrna polyadenylation signal, was cloned into the sspi site of the e3 region which is not ess ... | 2008 | 18249007 |
| canine adenovirus based rabies vaccines. | adenovirus based vectors are very attractive candidates for vaccination purposes as they induce in mammalian hosts potent humoral, mucosal and cellular immune responses to antigens encoded by the inserted genes. we have generated e1-deleted and replication-competent recombinant canine type-2 adenoviruses expressing the rabies virus glycoprotein (g). the effectiveness of both vectors to express a native g protein has been characterized in vitro in permissive cell lines. we compared the humoral an ... | 2008 | 18634509 |
| virologic survey of dogs with naturally acquired idiopathic conjunctivitis. | to determine the frequency of viral detection in conjunctival samples from client-owned domestic dogs with naturally acquired idiopathic conjunctivitis and to identify signalment, historical, and clinical findings positively associated with viral detection. | 2009 | 19827980 |
| immune responses in pigs induced by recombinant canine adenovirus 2 expressing the glycoprotein 5 of porcine reproductive and respiratory syndrome virus. | to develop a new type vaccine for porcine reproductive and respiratory syndrome (prrs) prevention by using canine adenovirus 2(cav-2) as vector, the glycoprotein 5(gp5) gene from prrsv strain jl was amplified by rt-pcr, and the expression cassette of gp5 was constructed using the human cytomegalovirus (hcmv) promoter and the simian virus 40 (sv40) early mrna polyadenylation signal. the expression cassette of glycoprotein 5 was cloned into the cav-2 genome in which e3 region had been partly delet ... | 2010 | 20432066 |
| fatal canine adenoviral pneumonia in two litters of bulldogs. | five bulldog pups, 4 weeks of age or younger, were presented over a 2-day period for postmortem examination and diagnostic evaluation. the pups originated from 2 different litters but had been cared for at a common facility since their birth. all 5 pups died after exhibiting symptoms consisting of lethargy, dyspnea, nasal discharge, anorexia, vomiting, diarrhea, and abdominal pain. necropsy examination revealed locally extensive to diffusely red, firm, consolidated lungs in all pups. histopathol ... | 2010 | 20807943 |
| development of a combined canine distemper virus specific rt-pcr protocol for the differentiation of infected and vaccinated animals (diva) and genetic characterization of the hemagglutinin gene of seven chinese strains demonstrated in dogs. | a combined reverse-transcription polymerase chain reaction (rt-pcr) method was developed for the detection and differentiation of wild-type and vaccine strains of the canine distemper virus (cdv). a pair of primers (p1/p2) was used to detect both cdv wild-type strains and vaccines. another pair (p3/p4) was used to detect only cdv wild-type strains. a 335bp fragment was amplified from the genomic rna of the vaccine and wild-type strains. a 555bp fragment was amplified specifically from the genomi ... | 2012 | 22108430 |
| prevalence and risk factors for viral exposure in rural dogs around protected areas of the atlantic forest. | despite the crucial role of domestic dogs as reservoirs for zoonosis and some of the most threatening diseases for wild carnivores such as distemper and parvovirosis, little is known about the epidemiological features and the risk factors involved in pathogen exposure of dogs that live in human/wildlife interfaces and actually contacts wildlife. through a cross-sectional serological approach and questionnaire survey, we assessed the prevalence along with individual and environment-associated ris ... | 2016 | 26822375 |
| pathogens of wild maned wolves (chrysocyon brachyurus) in brazil. | the maned wolf, chrysocyon brachyurus, is an endangered neotropical canid that survives at low population densities. diseases are a potential threat for its conservation but to date have been poorly studied. we performed clinical evaluations and investigated the presence of infectious diseases through serology and coprologic tests on maned wolves from galheiro natural private reserve, perdizes city, minas gerais state, southeastern brazil. fifteen wolves were captured between 2003 and 2008. we f ... | 2012 | 23060508 |
| serological detection of infection with canine distemper virus, canine parvovirus and canine adenovirus in communal dogs from zimbabwe. | domestic dogs are common amongst communities in sub-saharan africa and may serve as important reservoirs for infectious agents that may cause diseases in wildlife. two agents of concern are canine parvovirus (cpv) and canine distemper virus (cdv), which may infect and cause disease in large carnivore species such as african wild dogs and african lions, respectively. the impact of domestic dogs and their diseases on wildlife conservation is increasing in zimbabwe, necessitating thorough assessmen ... | 2014 | 25686382 |
| duration of immunity in red wolves (canis rufus) following vaccination with a modified live parvovirus and canine distemper vaccine. | there is growing information available regarding duration of immunity for core vaccines in both domestic and nondomestic species. vaccination protocols in nondomestic canids have frequently followed guidelines developed for the domestic dog; however, these protocols can be inappropriate for nondomestic canids such as the african wild dog (lycaon pictus), leaving some animals susceptible to infectious disease and others at risk for contracting vaccine-induced disease. in this study, red wolves (c ... | 2014 | 25314821 |
| epidemiology of viral pathogens of free-ranging dogs and indian foxes in a human-dominated landscape in central india. | there is an increasing concern that free-ranging domestic dog (canis familiaris) populations may serve as reservoirs of pathogens which may be transmitted to wildlife. we documented the prevalence of antibodies to three viral pathogens, canine parvovirus (cpv), canine distemper virus (cdv) and canine adenovirus (cav), in free-ranging dog and sympatric indian fox (vulpes bengalensis) populations in and around the great indian bustard wildlife sanctuary, in maharashtra, central india. a total of 2 ... | 2014 | 25135467 |
| high prevalence of antibodies against canine adenovirus (cav) type 2 in domestic dog populations in south africa precludes the use of cav-based recombinant rabies vaccines. | rabies in dogs can be controlled through mass vaccination. oral vaccination of domestic dogs would be useful in the developing world, where greater vaccination coverage is needed especially in inaccessible areas or places with large numbers of free-roaming dogs. from this perspective, recent research has focused on development of new recombinant vaccines that can be administered orally in a bait to be used as adjunct for parenteral vaccination. one such candidate, a recombinant canine adenovirus ... | 2013 | 23867013 |
| canine adenovirus type 1 and pasteurella pneumotropica co‑infection in a puppy. | in 2008, a 2 months-old male german shepherd was presented with fever, depression, and evident organic wasting. the puppy died within 48 hours after the onset of clinical signs. a complete necropsy was performed. bacteriological examination of samples from the brain, lung, liver, spleen, and bone marrow tested positive for pasteurella pneumotropica. histopathology demonstrated inflammatory and vascular lesions in the central nervous system and internal organs. canine adenovirus type 1 nucleic ac ... | 2017 | 27033531 |
| molecular epidemiology of canine adenovirus type 1 and type 2 in free-ranging red foxes (vulpes vulpes) in italy. | to date, no studies exist regarding the presence of canine adenovirus (cadv) infection in foxes in italy. furthermore, the majority of worldwide investigations regarding the presence of cadv in foxes have been carried out using common serological assays which are unable to differentiate between cadv type 1 and cadv type 2. to assess the presence of viral infection in italian red foxes (vulpes vulpes), thirty-two subjects shot during the regular hunting season in the province of pisa (tuscany, it ... | 2013 | 23201241 |
| surveillance for antibodies against six canine viruses in wild raccoons (procyon lotor) in japan. | raccoons (procyon lotor) are found worldwide. they are frequently seen in crowded inner cities as well as in forests or wooded areas, often living in proximity to humans and their pets. we examined sera from 100 wild raccoons in japan for antibodies to six canine viruses with veterinary significance to assess their potential as reservoirs. we also aimed to understand the distribution of potentially infected wildlife. we found that 7% of samples were seropositive for canine distemper virus (cdv), ... | 2017 | 28715293 |
| duration of immunity for canine and feline vaccines: a review. | in our studies aimed at assessing the minimum duration of vaccinal immunity (doi), approximately 1000 dogs have been vaccinated with products from all the major us veterinary biological companies. the doi for the various products is determined by antibody titers for all dogs and, by challenge studies in selected groups of dogs. recently, all major companies that make canine vaccines for the u.s. market have completed their own studies; published data show a 3 years or longer minimum doi for the ... | 2006 | 16707236 |
| structural and mutational analysis of human ad37 and canine adenovirus 2 fiber heads in complex with the d1 domain of coxsackie and adenovirus receptor. | adenovirus fibers from most serotypes bind the d1 domain of coxsackie and adenovirus receptor (car), although the binding residues are not strictly conserved. to understand this further, we determined the crystal structures of canine adenovirus serotype 2 (cav-2) and the human adenovirus serotype 37 (had37) in complex with human car d1 at 2.3 and 1.5a resolution, respectively. structure comparison with the had12 fiber head-car d1 complex showed that the overall topology of the interaction is con ... | 2006 | 16923808 |