| promotion of leishmanial infections in non-permissive host macrophages by conditioned medium. | leishmania enriettii grows well in guinea pig macrophages in culture but fails to do so in mouse macrophages. dialyzed and concentrated conditioned medium from l. enriettii cultures promoted the infection in the mouse macrophages at 37 degrees c and at 32 degrees c. similarly processed medium on which l. tropica had been cultured did not cause the same effect. immune precipitation of the conditioned medium by anti-leishmania serum cancelled out the effect. infections of guinea pig macrophages by ... | 1977 | 919693 |
| protection of guinea pigs against cutaneous leishmaniasis by combined infection and chemotherapy. | a paromomycin and methylbenzethonium chloride ointment cured leishmania enriettii infections in guinea pigs. amastigotes were totally eliminated from the treated lesion after 10 days of treatment. a delayed effect also occurred on untreated lesions in the same animals. lesions treated at various times after infection permitted protective immunity to develop, and 90% of treated animals were refractory to reinfection. | 1986 | 3943909 |
| the effect of prolonged treatment with antilymphocyte serum on the course of infections with bcg and leishmania enriettii in the guinea-pig. | | 1971 | 4108131 |
| experimental cutaneous leishmaniasis. iv. selective suppression of cell-mediated immunity during the response of guinea-pigs to infection with leishmania enriettii. | | 1974 | 4619877 |
| effect of levamisole on the course of experimental leishmaniasis in guinea-pigs and mice: haematological and immunological findings. | the effects of levamisole on the course of leishmania enriettii infection in guinea-pigs and l. major in mice were investigated. it was demonstrated that levamisole-treated guinea-pigs either did not develop an ulcerative lesion or developed a much smaller lesion than untreated animals. moreover, metastases which are commonly produced in approximately 50% of animals receiving 2 x 10(6) l. enriettii did not occur in levamisole-treated guinea-pigs. leishmania enriettii infection usually causes leu ... | 1988 | 3266914 |
| establishment of cutaneous leishmania enriettii infection in hamsters. | a model of a self-healing type of cutaneous leishmaniasis was established in hamsters using the guinea pig parasite leishmania enriettii. l. enriettii was passaged several times in hamsters without losing its infectivity for guinea pigs or for hamsters. the course of the infection in hamsters resembled that of guinea pigs, with the exception that the lesion at the site of parasite inoculation did not ulcerate and no metastatic lesions developed spontaneously. moreover, unlike guinea pigs, infect ... | 1976 | 1279005 |
| the montenegro reaction in guinea pigs infected by leishmania enriettii and the effect of antigens prepared from various leishmania isolates. | all antigens (leishmanin) prepared from nine isolates of leishmania gave positive skin tests in guinea pigs infected with l. enriettii. however, variation in potency was observed and ascribed to batch variation. it is recommended that biological testing of leishmanin is considered before use in field surveys or as an aid to clinical diagnosis. | 1976 | 1271510 |
| [experimental leishmaniasis in guinea pig; leishmania enrietti muñiz and medina, 1948]. | | 1953 | 13088666 |
| the fine structure of leishmania enriettii in the guinea pig. | | 1975 | 1201899 |
| mucocutaneous leishmaniasis in guinea-pigs inoculated intravenously with leishmania enriettii. preliminary report. | seven guinea-pigs were inoculated intravenously with a rich suspension of leishmania enriettii. during the sixth to the seventh week from inoculation, all of them developed lesions within the anterior nasal mucosa and in the vulva or scrotum. in one animal nodules occurred in the forepaws during the tenth week. the histology of the latter showed an epithelioid granuloma with multinucleate giant cells, while in all the others macrophages and monocytes highly parasitized with leishmania bodies, fo ... | 1975 | 1182080 |
| [not available]. | | 1948 | 18908199 |
| the biting midge culicoides sonorensis (diptera: ceratopogonidae) is capable of developing late stage infections of leishmania enriettii. | despite their importance in animal and human health, the epidemiology of species of the leishmania enriettii complex remains poorly understood, including the identity of their biological vectors. biting midges of the genus forcipomyia (lasiohelea) have been implicated in the transmission of a member of the l. enriettii complex in australia, but the far larger and more widespread genus culicoides has not been investigated for the potential to include vectors to date. | 2015 | 26367424 |
| leishmania enriettii: biochemical characterisation of lipophosphoglycans (lpgs) and glycoinositolphospholipids (gipls) and infectivity to cavia porcellus. | leishmania enriettii is a species non-infectious to man, whose reservoir is the guinea pig cavia porcellus. many aspects of the parasite-host interaction in this model are unknown, especially those involving parasite surface molecules. while lipophosphoglycans (lpgs) and glycoinositolphospholipids (gipls) of leishmania species from the old and new world have already been described, glycoconjugates of l. enriettii and their importance are still unknown. | 2015 | 25595203 |
| anti-leishmania activity of normal animal sera. | the growth inhibition activity of normal human, dog, rabbit, guinea pig, rat, sheep, cat, mouse and chicken sera was quantified against leishmania enriettii and leishmania tropica. the pattern of anti-l. enriettii activity of various animal sera was somewhat different from that observed in l. tropica. against l. enriettii, mouse serum was inactive, and against l. tropica rat and mouse sera were inactive. all the other animal sera tested had growth inhibition activity on both leishmanias. this gr ... | 1975 | 1124967 |
| modification of cutaneous leishmaniasis in the guinea-pig by cyclophosphamide. | pretreatment of guinea-pigs with cyclophosphamide (cy) (300 mg/kg) 3 days before cutaneous infection with leishmania enriettii caused an increased intensity of the lesion at the site of infection and an increase in the incidence of widespread metastases. decreased levels of circulating antibody were found from the first to fourth week after infection. decreased delayed type hypersensitivity could only be detected beyond 4 weeks. peritoneal macrophages obtained form guinea-pigs 3 days after cy pr ... | 1976 | 949870 |
| antigenic components of the protozoan parasite leishmania enriettii inducing humoral and cell-mediated immune responses in infected guinea-pig. | | 1977 | 881221 |
| mechanisms of protective immunity in experimental cutaneous leishmaniasis of the guinea-pig. i. lack of effects of immune lymphocytes and of activated macrophages. | leishmania enriettii is an obligatory intracellular protozoan parasite which infects guinea-pigs and resides in macrophages. subcutaneous inoculation produces a skin infection which heals spontaneously and leaves the animal immune to reinfection. experiments have been performed to explore the mechanisms of parasite destruction in the recovering and immune animal. using quantitative techniques to assess parasite survival it was found that l. enriettii is not killed in vitro in macrophages from im ... | 1975 | 813928 |
| the quantification of viable leishmania enriettii from infected guinea-pig tissues. | results are presented demonstrating that in vitro cultivation of leishmania enrietti can be used to determine the level of viability in suspensions of l. enrietti used for infection and also to quantify the number of viable organisms in infected tissues. | 1979 | 466861 |
| hemagglutination of neuraminidase-treated human erythrocytes by leishmania enriettii infected guinea-pig sera. | sera from guinea-pigs infected with the protozoan parasite leishmania enriettii showed higher hemagglutination (ha) titres for neuraminidase treated human erythrocytes than those of normal guinea-pig sera. this ha activity was associated mostly with the 19s fraction of the immune serum and could be absorbed out with an antigenic fraction of the parasite membrane. antigenic determinants involved in this ha reaction consisted of, at least, beta-d-galactosyl or lactosyl residues. | 1976 | 60254 |
| naturally acquired infections with leishmania enriettii muniz and medina 1948 in guinea-pigs from são paulo, brazil. | two domestic guinea-pigs (cavia porcellus), bought in pinheros, são paulo state, brazil, were taken by their owners to a farm in the rural district of capão bonito, close to the atlantic forest, são paulo, where they both developed tumour-like and ulcerating lesions on the ears. the causative agent was identified as leishmania (l.) enriettii, based on biological characters and isoenzyme profiles. sources of the parasite in wild mammals, and the possible sandfly vector species are discussed. | 1994 | 8084659 |
| histological studies of the elimination of leishmania enriettii from skin lesions in the guinea-pig. | nineteen guinea-pigs were each inoculated intradermally with 10(6) amastigotes of leishmania enriettii, and the development of the lesions was followed from weeks 4 to 10 with a view to elucidating the histological mechanisms involved with the elimination of parasites. electron microscopic observations were made in 1 animal. extensive necrosis of the parasite-laden macrophages was observed in 7 out of 7 animals at 4 and 5 weeks. in the ulcerated core of the lesion at 4 weeks no intact macrophage ... | 1980 | 7459254 |
| leishmania enriettii amastigotes: demonstration of fibrillar surface. | an extensive fibrillar surface was identified in situ by transmission electron microscopy on the amastigote stage of the macrophage intracellular parasite, leishmania enriettii. attachment to the amastigote surface of 20-160-nm fibrils was clearly evident on organisms that had been isolated from guinea pigs. surface fibrils were not detected after in vitro transformation of the amastigote to the promastigote. incubation of amastigotes in heat-inactivated guinea pig serum containing a high titer ... | 1982 | 7142748 |
| macrophage heterogeneity and ir-gene control as factors involved in the immune response of guinea pigs to infection with leishmania enrietti. | | 1981 | 6786761 |
| activation of the alternative complement pathway by leishmania promastigotes: parasite lysis and attachment to macrophages. | when exposed to normal human or guinea pig sera, promastigotes of leishmania enriettii and l. tropica activate the complement cascade by the alternative pathway and fix c3 on their surfaces. in high (25%) serum concentrations, the result of complement activation is parasite lysis. at lower concentrations (4%), complement fixation results in enhanced parasite binding and uptake into murine peritoneal macrophages. parasites are lysed in normal guinea pig, c4-deficient guinea pig, normal human, and ... | 1984 | 6363545 |
| in vitro analysis of immune responses of inbred guinea pigs infected in vivo with leishmania enriettii and an investigation of active immunization of susceptible animals. | adherent skin cell monolayers have been prepared from the infected area of inbred guinea pigs inoculated with leishmania enriettii. cells from those animals most susceptible to disease (2/n) are less able to promote proliferation and the production of macrophage migration inhibition factor (mif) from leishmania-immune lymphocytes than are infected cells taken from the more resistant 13/n or (2/n x 13/n)f1 animals. exposure of immune lymphocytes of all strains to parasite antigen in the relative ... | 1983 | 6339078 |
| [immunity in leishmania enriettii infection of the guinea pig]. | | 1965 | 5885827 |
| [allergic reactions in guinea-pigs to repeated inoculation with leishmania enrietti]. | | 1965 | 5877785 |
| histological appearance of the site of inoculation and lymph nodes of guinea-pigs at various times after infection with leishmania enriettii. | | 1972 | 5048788 |
| course of development of leishmania enriettii infection in immunosuppressed guinea pigs. | | 1973 | 4717689 |
| experimental cutaneous leishmaniasis. ii. effects of immunosuppression and antigenic competition on the course of infection with leishmania enriettii in the guinea-pig. | | 1972 | 4625799 |
| antibody-induced movement of membrane components of leishmania enriettii. | incubation in vitro of viable leishmania enriettii with antibodies from infected or immune guinea pigs and a fluorescein-labeled antiguinea pig ig conjugate induced aggregation of surface antigens to form a "cap" over the anterior pole of the amastigote and over both the anterior and posterior poles of the promastigote form of the parasite. cap formation occurred only with optimum quantities of guinea pig antibodies and was inhibited by low temperature and the metabolic inhibitors, sodium azide ... | 1974 | 4596509 |
| immunoflorescence studies of leishmania enriettii infection in the guinea pig. | | 1974 | 4142526 |
| new isolation of leishmania enriettii muniz and medina, 1948 in paranástate, brazil, 50 years after the first description, and isoenzymatic polymorphism of the l. enriettii taxon. | three cases of cutaneous leishmaniasis in guinea-pigs from a rural area near curitiba (paraná state, brazil) are reported. the three parasite isolates were characterized by isoenzyme electrophoresis as leishmania enriettii, of which two distinct zymodemes were observed. | 1996 | 8915125 |
| comparison of adjuvants with leishmania antigens in a guinea pig model to induce delayed-type hypersensitivity responses. | guinea pigs have been a traditional model for studies of delayed-type hypersensitivity. they are the natural host of leishmania enriettii and have been experimentally infected with other species of leishmania. they have been used as a skin-test model to screen potential antigens for use in diagnostic tests for leishmania. use of complete freund's adjuvant (cfa), along with whole promastigote leishmania antigen, was necessary to sensitize guinea pigs to invoke a sufficient cell-mediated immune re ... | 1999 | 10551453 |
| [various cases of spontaneous cure of nasal lesions in guinea pigs experimentally infected with leishmania enriettii, muniz and medina, 1948]. | | 1954 | 13204835 |
| the specificity of the sabin-feldman dye test with reference to protozoal infections. | infections of eimeria stiedae in normal and splenectomized rabbits and of leishmania enriettii in normal rabbits and guinea-pigs and in splenectomized rabbits did not produce dye test antibodies. guinea-pigs injected with atoxoplasma sp. and rabbits immunized with cultures of crithidia fasciculata were found to be negative for dye test antibodies. mice which had been infected with trypanosoma cruzi did not show dye test antibodies. all these animals, except one guinea-pig infected with leishmani ... | 1960 | 14412642 |
| [morphologic and cytochemical studies of lymph nodes and spleen in leishmaniasis in guinea-pigs (leishmania enrietti)]. | | 1965 | 5876191 |