| borna disease in cats. | | 1999 | 10460034 |
| prevalence of borna disease virus antibodies in healthy japanese black cattle in kyushu. | epidemiological studies have demonstrated that asymptomatic infection of borna disease virus (bdv) is found in various species of animals in japan. recent reports have also revealed that neurological diseases caused by this virus could exist in horses, cattle, a dog, and cats in this country. in this study, we investigated seroprevalence of bdv antibodies in japanese black cows reared in kyushu, the southernmost main island of japan, using elisa and western-immunoblotting. of 101 serum samples, ... | 2006 | 16520541 |
| investigation of schizophrenic patients from istanbul, turkey for the presence of west nile virus. | association of some neurotropic viruses like borna disease virus and herpes virus with schizophrenia is better explained. however, the role of west nile virus (wnv) infection in schizophrenia is not well documented. therefore, this study was performed to investigate possible association between schizophrenia and presence of antibodies and wnv rna in schizophrenic patients. for this, 200 blood samples from patients with schizophrenia and 200 from control groups were collected in istanbul, turkey. ... | 2011 | 21725713 |
| host and viral traits predict zoonotic spillover from mammals. | the majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, hiv, ebola and sars). understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals for pandemic surveillance programs. however, few analytical tools exist to identify which host species are likely to harbour the next human virus, or which viruses can cross species ... | 2017 | 28636590 |
| expression of interferon gamma in the brain of cats with natural borna disease virus infection. | borna disease virus (bdv) is a neurotropic, negative-stranded rna virus, which causes a non-suppurative meningoencephalomyelitis in a wide range of animals. in cats, bdv infection leads to staggering disease. in spite of a vigorous immune response the virus persists in the central nervous system (cns) in both experimentally and naturally infected animals. since the cns is vulnerable to cytotoxic effects mediated via nk-cells and cytotoxic t-cells, other non-cytolytic mechanisms such as the inter ... | 2011 | 21419498 |
| borna disease virus: evidence of naturally-occurring infection in cats in australia. | in europe, borna disease virus (bdv) infection has been linked with staggering disease. the aim of this study was serological investigation for bdv infection in australian cats. de-identified sera were obtained from domestic cats presented at various veterinary clinics. bdv antigen levels were measured by a monoclonal antibody-based elisa. antibody to bdv measured semiquantitatively by elisa was detected in 0.8% of cats from south australia and 3.2% of animals from nsw confirmatory assays for el ... | 2008 | 18771098 |
| borna disease virus (bdv) infection in cats. a concise review based on current knowledge. | persistent viral infections of the central nervous system have been the subject of intense interest for decades. one of these viral agents has been identified as borna disease virus (bdv) of the family bornaviridae. there have been various reports that link bdv to staggering disease in cats, with symptoms that include ataxia and behavioural disorders, and the disease is often referred to as feline borna disease. serological and molecular detection of bdv has been reported at a higher prevalence ... | 2006 | 16841569 |
| letter to the editor refuting "epidemiological pattern of classical borna disease and regional genetic clustering of borna disease viruses point towards the existence of to-date unknown endemic reservoir host populations" by ralf dürrwald, jolanta kolodziejek, aemero muluneh, sibylle herzog and norbert nowotny, microbes and infection 8 (2006) 917-929. | | 2006 | 16616572 |
| borna disease virus and mental health: a cross-sectional study. | borna disease is an infectious neurological disease of horses, sheep and possibly other animals. a role for borna disease virus (bdv) in human neurological and psychiatric illness has been proposed, but this hypothesis remains controversial. | 2005 | 15760925 |
| active borna disease virus polymerase complex requires a distinct nucleoprotein-to-phosphoprotein ratio but no viral x protein. | analysis of the composition and regulation of the borna disease virus (bdv) polymerase complex has so far been limited by the lack of a functional assay. to establish such an assay on the basis of an artificial minigenome, we constructed expression vectors encoding either nucleoprotein (n), phosphoprotein (p), x protein, or polymerase (l) of bdv under the control of the chicken beta-actin promoter. a flag-tagged version of l colocalized with virus-encoded n and p in characteristic nuclear dots o ... | 2003 | 14557662 |
| neuropharmacological sequelae of persistent cns viral infections: lessons from borna disease virus. | borna disease virus (bdv) is a neurotropic rna virus that is worldwide in distribution, causing movement and behavior disorders in a wide range of animal species. bdv has also been reported to be associated with neuropsychiatric diseases of humans by serologic study and by recovery of nucleic acid or virus from blood or brain. natural infections of horses and sheep produce encephalitis with erratic excited behaviors, hyperkinetic movement or gait abnormalities; naturally infected cats have ataxi ... | 2003 | 12667891 |
| madness. | | 2002 | 12219740 |
| detection of anti-borna disease virus antibodies from cats in asian countries, japan, philippines and indonesia using electrochemiluminescence immunoassay. | anti-borna disease virus (bdv) antibodies were detected from cats in japan, philippines and indonesia by using electrochemiluminescence immunoassay. positive rates were 3.1%, 3.8% and 2.0% in japan, philippines and indonesia, respectively. there was no differences in the positive rate of anti-bdv antibodies between male and female cats and among habitats. while, a significantly (p<0.05) higher prevalence (6.5%) was found in the oldest age group (more than 6 years) cats. | 2001 | 11558551 |
| [the neuropathogenesis of borna disease virus infection]. | borna disease virus(bdv) is a noncytolytic, neurotropic rna virus that causes a disease of the central nervous system(cns) in several vertebrate species, including horses, sheep, cats and ostriches. epidemiological studies using peripheral blood or brain samples revealed that bdv can infect humans and that it may be related with certain neuropsychiatric disorders. the unique genetic and biological properties of bdv indicate that bdv develops a persistent infection in the cns. furthermore, a line ... | 2001 | 11519168 |
| borna disease in a free-ranging lynx (lynx lynx). | a free-ranging lynx (lynx lynx) was shot because of its abnormal behavior. histopathological examination revealed a nonsuppurative meningoencephalitis. in situ hybridization, immunohistochemistry, and reverse transcriptase pcr analysis showed the presence of borna disease virus infection in the brain. to our knowledge, this is the first confirmed case of borna disease in a large felid. | 2000 | 10921984 |
| borna disease: a possible emerging zoonosis. | the borna disease virus (bdv) causes a disease of the central nervous system (cns) in several vertebrate species. the progress made over the last 30 years in molecular biology has allowed us to identify the unique characteristics of the virus, such as its persistence in the cns and the way it is expressed. this has allowed scientists to classify this pathogenic agent in a new family of rna viruses. bdv affects a very large spectrum of hosts and is responsible for a disease characterised by behav ... | 1999 | 10596403 |
| peripheral and intracerebral t cell immune response in cats naturally infected with borna disease virus. | borna disease virus (bdv) is a neurotropic agent with capacity to cause encephalomyelitis in a wide range of animal species, including horses and cats. recent studies also point to a link between bdv and human neuropsychiatric disorders. the pathogenesis of borna disease (bd) has been proposed to be immune-mediated, mainly through the effects of cytotoxic t cells. we used flow cytometric analysis in order to characterize the peripheral and intracerebral t cell immune response in cats naturally i ... | 1999 | 10438323 |
| a variant form of feline borna disease. | borna disease virus (bdv) is a neurotropic agent with capacity to infect and cause encephalomyelitis in a wide range of animals, including horses, sheep, cattle and cats. recent interest in bdv as a potential human pathogen has been stimulated by reports of bdv-specific antibodies and nucleic acid in patients with neuropsychiatric diseases. the pathogenesis of borna disease (bd) in naturally infected animals is believed to be immune-mediated, mainly through the action of cytotoxic t cells. in th ... | 1998 | 9807733 |
| demonstration of borna disease virus (bdv) in specific regions of the brain from horses positive for serum antibodies to bdv but negative for bdv rna in the blood and internal organs. | sero- and molecular-epidemiological studies on borna disease virus (bdv) infection show that bdv rna is not always detected in the peripheral blood mononuclear cells (pbmcs) from serum anti-bdv antibody-positive individuals such as horses, sheep, cattle, cats, and humans. in this study we demonstrated bdv rna signals by polymerase chain reaction only in restricted regions of the brain from horses with locomotor disease. four of six horses examined showed apparently positive reactions for anti-bd ... | 1997 | 9255762 |
| high prevalence of borna disease virus infection in healthy sheep in japan. | previous seroepidemiological and molecular epidemiological studies of borna disease virus (bdv) showed considerably high rates of infection in horses, cattle, cats, and humans in hokkaido, japan. here, we further demonstrate high rates of specific antibodies to bdv and bdv rna in peripheral blood mononuclear cells (pbmcs) from healthy sheep bred on the same island. the bdv prevalences by immunoblotting and/or reverse transcriptase pcr were 0% (0 of 19) in newborns (<1 month old), 51.7% (15 of 29 ... | 1997 | 9144374 |
| demonstration of borna disease virus rna in peripheral blood mononuclear cells derived from domestic cats in japan. | borna disease virus (bdv) naturally infects horses, sheep, and several other species, including humans, and it is believed to be related to neurological disorders. bdv infection in domestic cats has also been demonstrated by serological assays. we demonstrated for the first time bdv rna in peripheral blood mononuclear cells from 11 of 83 (13.3%) randomly selected domestic cats in japan by nested reverse transcriptase-pcr. the bdvs from cats were similar to but slightly different from those from ... | 1996 | 8748301 |
| staggering disease in cats: isolation and characterization of the feline borna disease virus. | a borna disease virus (bdv)-like agent was isolated from the central nervous system (cns) of cats with a spontaneous non-suppurative encephalomyelitis ('staggering disease'). in contrast to the rabbit-adapted bdv strain v, which can be propagated in several primary and permanent cell cultures, the cat virus grew only in embryonic mink brain cells. infection of adult wistar rats with feline brain tissue material did not result in clinical disease during a period of 5 months, nor in growth of infe ... | 1995 | 7561758 |