| eosinophil hyporesponse of jirds induced by microfilariae of brugia pahangi. | male jirds (meriones unguiculatus) were inoculated sc with 100 infective larvae of brugia pahangi. after 16 weeks, the animals were reinoculated with a comparable number of organisms. blood eosinophil responses during the 5 weeks subsequent to this attempt to reinfect were much lower than those of comparable naive animals, while the response to a heterologous infection (toxocara canis) was comparable to that of controls. mebendazole was given to infected animals for 2 weeks beginning 5 weeks (pr ... | 1989 | 2774064 |
| does the eosinophil have a protective role in amebiasis? | while normal human eosinophils are destroyed in vitro by virulent entamoeba histolytica, notwithstanding the presence of antibodies and complement, activated eosinophils promptly destroy the parasite although dying also at the end of the process. to study the possible in vivo participation of eosinophils in invasive amebiasis, we compared the induction of experimental amebic abscess of the liver (aal) in gerbils (meriones unguiculatus) previously made eosinophilic through toxocara canis antigen ... | 1997 | 9698942 |
| new animal model for human ocular toxocariasis: ophthalmoscopic observation. | although human ocular toxocariasis causes severe vision defect, little is known about its aetiology, diagnosis, and treatment. to develop a new animal model for human ocular toxocariasis, ophthalmological findings of fundi in mongolian gerbils, meriones unguiculatus, and balb/c mice were investigated following infection with toxocara canis. | 1999 | 10413704 |
| cerebellar ataxia due to toxocara infection in mongolian gerbils, meriones unguiculatus. | we assessed the usefulness of gerbils as an experimental model for neurologic toxocarosis. mongolian gerbils, meriones unguiculatus, infected with toxocara canis or toxocara cati (1000 eggs/gerbil) showed progressive neurologic disorders from 50 days after infection in t. canis-infected gerbils or from 120 days after infection in t. cati-infected gerbils. the incidence of the onset was 6 of the 13 gerbils (49%) in the t. canis-gerbils and 5 of the 7 gerbils (71%) in the t. cati-gerbils. histopat ... | 2003 | 12719137 |
| larval migration of the ascarid nematode toxocara canis following infection and re-infection in the gerbil meriones unguiculatus. | a morphological and immunohistochemical study of larval migration patterns was performed in gerbils that were infected once (primary infected group) or twice (secondary infected group) with 1500 eggs of toxocara canis. animals from the primary infected and the re-infected group were killed at different times after infection, and larvae were counted in the intestines, liver, lungs and brain. fragments of all organs were formalin fixed and paraffin embedded for histology and immunohistochemistry a ... | 2016 | 26337823 |
| toxocara canis: larval migration dynamics, detection of antibody reactivity to larval excretory-secretory antigens and clinical findings during experimental infection of gerbils (meriones unguiculatus). | in this study, mongolian gerbils were used to analyse features of toxocara infection that included larval migration, humoral immune responses to toxocara canis excretory-secretory antigens (tes) and aspects of host physiology. at day 10 post-infection (p.i.) most larvae were in the intestine and the lungs while later the total number of larvae was higher in the carcass tissue; the number of larvae per gram of tissue was lower elsewhere other than in the brain. infected animals showed several neu ... | 2009 | 19545524 |
| ocular lesions in gerbils (meriones unguiculatus) infected with low larval burden of toxocara canis: observations using indirect binocular ophthalmoscopy. | to study the frequency of ocular lesions in 30 gerbils infected with 100 embryonated eggs of toxocara canis, indirect binocular ophthalmoscopy was performed 3, 10, 17, 24, 31 and 38 days after infection. all the animals presented larvae in the tissues and 80% presented ocular lesions. hemorrhagic foci in the choroid and retina were present in 92% of the animals with ocular lesions. retinal exudative lesions, vitreous lesions, vasculitis and retinal detachment were less frequent. mobile larvae or ... | 2008 | 19142434 |
| migration behaviour and pathogenesis of five ascarid nematode species in the mongolian gerbil meriones unguiculatus. | to understand the characteristic features of the mongolian gerbil, meriones unguiculatus, as an animal model of ascarid infections, the migration behaviour and pathogenesis of larvae were investigated in experimentally infected gerbils. embryonated eggs from each of toxocara canis, baylisascaris procyonis, b. transfuga, ascaris suum, and a. lumbricoides were orally inoculated into gerbils and larvae were recovered from various organs at designated periods. in t. canis-infected gerbils, larvae we ... | 2007 | 17381866 |
| evidence for the involvement of the optic nerve as a migration route for larvae in ocular toxocariasis of mongolian gerbils. | although toxocara canis, an important pathogen of ocular disease, tends to migrate to the eye, the precise migratory route has yet to be determined experimentally. mongolian gerbils, meriones unguiculatus, known as a useful animal model for human toxocariasis, were used to investigate the migration route toward the eyes. infective larvae of t. canis were directly inoculated into the intracranial region. haemorrhagic lesions or larvae were observed in 56.3% of cases. histopathologically, a larva ... | 2003 | 14627447 |
| the epidemiology of ocular toxocariasis. | ocular toxocariasis damages vision and may cause blindness. it is a relatively 'new' disease, the histological changes having been described in 1950 and the causative organism identified in 1956. many aspects of the epidemiology of toxocariasis are unclear. it is generally accepted that the usual route of entry to the eye is via the blood stream. once the eye is invaded characteristic changes are produced with comparative sparing of the anterior segment. species differences in susceptibility can ... | 2001 | 11520433 |
| ocular larva migrans caused by toxocara cati in mongolian gerbils and a comparison of ophthalmologic findings with those produced by t. canis. | to elucidate the pathogenic potential of toxocara cari, we observed the ophthalmologic changes of the fundi in mongolian gerbils, meriones unguiculatus, after oral inoculation of 17 embryonated eggs/g body weight. ophthalmic conditions in 8 t. cati-infected gerbils were monitored using an ophthalmoscope from day 0 to day 156 and were compared with those of 57 t. canis-infected gerbils. the results showed that t. cati larvae migrated into the eye of the gerbil and then elicited ophthalmic changes ... | 2000 | 11128493 |
| antigen induced eosinophilia protects gerbils (meriones unguiculatus) against experimental amebic abscess of the liver. | while the normal human eosinophil is destroyed in vitro by virulent entamoeba histolytica, notwithstanding the presence of antibodies and complement, activated eosinophils promptly destroy the parasite even though succumbing in the process as well. to study the possible in vivo participation of eosinophils in invasive amebiasis, we compared the induction of experimental amebic abscess of the liver (eaal) in gerbils (meriones unguiculatus) previously made eosinophilic (532 +/- 80 eosinophils/mm3) ... | 1995 | 8845666 |