| brugia pahangi and dirofilaria immitis: experimental infections in the ferret, mustela putorius furo. | | 1979 | 446585 |
| dirofilaria immitis: experimental infections in the ferret (mustela putorius furo). | the ferret, mustela putorius furo, was found to be susceptible to dirofilaria immitis infection when exposed to low (14) or high (280-420) numbers of infective larvae harvested from aedes aegypti. eight ferrets (half of them cortisonized) were inoculated subcutaneously with 14 larvae each. all of them were subsequently found to harbor d. immitis in the heart, and all but one of them had worms of both sexes. six of these ferrets were examined for microfilaremia at 31 to 35 weeks after inoculation ... | 1978 | 627949 |
| trial of avermectin b1a, mebendazole and melarsoprol against pre-cardiac dirofilaria immitis in the ferret (mustela putorius furo). | avermectin b1a was found active against the pre-cardiac stage of dirofilaria immitis in ferrets. the drug was given orally, at 0.2 mg/kg, on days 38--42 of infection. at necropsy, 5 1/2 months after inoculation, worms were almost totally absent from the hearts of these ferrets. the efficacy of melarsoprol against developing dirofilaria, which has been demonstrated in dogs by other workers, was demonstrated in ferrets given oral doses, at 100 mg/kg, on days 38--42 of infection. the reported effic ... | 1978 | 739297 |
| investigation of ecdysteroid excretion by adult dirofilaria immitis and brugia pahangi. | the excretion of ecdysteroids by the filarial nematode species, dirofilaria immitis and brugia pahangi, was examined both in vitro, by the analysis of culture medium, and in vivo, through analysis of serum samples from experimentally infected hosts. there was no evidence of ecdysteroid excretion by intact parasites of either species in vitro. free ecdysteroids were detected in the serum of ferrets and dogs infected with d. immitis, but concentrations would be at or below the limit of detection i ... | 1990 | 2320053 |
| dirofilariasis in a ferret. | an adult male ferret was found to be lethargic and dyspneic. necropsy revealed 21 worms in the heart, vena cava, and pulmonary artery. the worms were identified as dirofilaria immitis. histologic examination of lung tissue revealed numerous microfilariae. | 1986 | 3710876 |
| development of dirofilaria immitis third stage larvae (nematoda: filarioidea) in micropore chambers implanted into surrogate hosts. | groups of 100 third stage larvae of dirofilaria immitis recovered from aedes aegypti were loaded into 250 microliters capacity micropore chambers (0.3 micron pore size) and implanted into the peritoneal cavity of mice, jirds, cotton rats and ferrets. in all hosts 74-87% of larvae moulted by 74 hours, with less than 5% mortality. the fourth stage worms recovered at 74 hours were cultured in vitro in l-15 (leibovitz) medium plus 20% foetal bovine serum with a dog sarcoma feeder cell line. after 96 ... | 1985 | 3890119 |
| brugia malayi: intravenous injection of microfilariae in ferrets as an experimental method for occult filariasis. | microfilaremia, immune responses, and pathology were compared in ferrets infected with 100 third-stage larvae of brugia malayi (subperiodic strain) or injected intravenously with 10(6) microfilariae. ferrets (mustela putorius furo) inoculated with third-stage larvae typically became patent during the third month after infection, with a mean patency of 123 +/- 25 (se) days. ferrets injected intravenously with microfilariae exhibited a relatively constant microfilaremia for 3-4 weeks and usually c ... | 1985 | 4029349 |
| dirofilaria immitis infection in three ferrets. | | 1984 | 6706805 |
| suppression of maturation of dirofilaria immitis in mustela putorius furo by single dose of ivermectin. | | 1980 | 6893467 |
| immunization of ferrets against dirofilaria immitis by means of chemically abbreviated infections. | ferrets were exposed to two successive inoculations with 30 third-stage larvae of the canine heartworm dirofilaria immitis, the inoculations being approximately 5 months apart. each infection was terminated by ivermectin therapy approximately 2 months after inoculation. the ferrets were challenged with 30 larvae 3 weeks after the termination of the second infection, and were necropsied approximately 6 months after challenge. of the four ferrets that survived this protracted experimentation, two ... | 1981 | 6894638 |
| efficacy of ivermectin against third-stage dirofilaria immitis larvae in ferrets and dogs. | ivermectin prevented maturation of dirofilaria immitis when given per os to ferrets at a dosage of 0 x 1 mg ivermectin per kg bodyweight two days after inoculation with third stage heartworm larvae. similar results were found in dogs treated one day after infection at a dosage of 0 x 05 mg ivermectin per kg. no heartworm were found in the hearts and lungs of five treated dogs compared to an average of 11 worms per dog in five control animals. | 1982 | 6897584 |
| efficacy of the avermectins against filarial parasites: a short review. | the avermectins are macrocyclic lactones produced by streptomyces avermitilis. one of them has been chemically modified and given the non-proprietary name ivermectin. the compounds have shown efficacy against various stages of filarial parasites. with respect to pre-adult stages in the mammalian host, activity has been observed against dirofilaria immitis in ferrets and dogs, and dipetalonema viteae and litomosoides carinii in jirds (meriones); but activity has not been observed against the deve ... | 1982 | 7051527 |
| early migration and development of dirofilaria immitis in the ferret, mustela putorius furo. | twenty-four female ferrets, approximately 4 mo of age, were subcutaneously inoculated with 60 infective larvae of dirofilaria immitis to determine migration and development of the worms until they became young adults in the heart and associated vessels. twelve groups of 2 ferrets each were examined at 3, 5, 11, 15, 21, 49, 56, 63, 70, 91, 119, and 140 days postinoculation, respectively, to recover worms. total worm recovery from each ferret varied from 1.6 to 79.3%. worms were found mostly in su ... | 1994 | 8158467 |
| dirofilariasis in the domestic ferret. | the popularity of pet ferrets in heartworm-endemic and -nonendemic areas is growing, with ferret ownership in the united states currently exceeding 10 million. the domestic ferret (mustela putorius furo) has been reported to be susceptible to naturally-acquired and experimentally-induced infections of dirofilaria immitis. host-parasite relationships between d. immitis and domestic dogs and cats have been well studied, but there have been relatively few reports on infections in ferrets. laborator ... | 1998 | 9753800 |
| echocardiographic diagnosis of dirofilariasis in a ferret. | heartworm disease is described in a 14-month-old neutered female ferret (mustela putorius furo) which had a three-week history of sneezing, anorexia and dyspnoea. echocardiography revealed the presence of heartworms as hyperechoic densities within the right atrial and ventricular cavities. at necropsy, four dirofilaria immitis parasites (three females, one male) were found in the right heart, the cranial vena cava and the caudal vena cava. histopathological findings were similar to those reporte ... | 2000 | 10812548 |
| an unidentified filarial species and its impact on fitness in wild populations of the black-footed ferret (mustela nigripes). | disease can threaten the restoration of endangered species directly by substantially decreasing host survival or indirectly via incremental decreases in survival and reproduction. during a biomedical survey of reintroduced populations of the highly endangered black-footed ferret from 2002 to 2005, microfilariae discovered in the blood were putatively identified as dirofilaria immitis, and widespread screening was initiated using a commercially available antigen-based elisa test. a subset of anim ... | 2008 | 18263821 |
| heartworm disease in animals and humans. | heartworm disease due to dirofilaria immitis continues to cause severe disease and even death in dogs and other animals in many parts of the world, even though safe, highly effective and convenient preventatives have been available for the past two decades. moreover, the parasite and vector mosquitoes continue to spread into areas where they have not been reported previously. heartworm societies have been established in the usa and japan and the first european dirofilaria days (fedd) conference ... | 2008 | 18486691 |
| autochthonous dirofilaria immitis infection in a ferret with aberrant larval migration in europe. | a two-year-old male ferret (mustela putorius furo) was presented to the faculty of veterinary science, szent istván university, for investigation of somnolence. following unsuccessful therapeutic attempts, the ferret was euthanased and a male dirofilaria immitis worm was found in the pulmonary artery and a female d. immitis specimen in the subdural space of the cranial cavity. to the authors' knowledge, this is the first european record of d. immitis infection in a ferret, and the first case in ... | 2010 | 20626785 |