| isolation and characterization of adenoviruses persistently shed from the gastrointestinal tract of non-human primates. | adenoviruses are important human pathogens that have been developed as vectors for gene therapies and genetic vaccines. previous studies indicated that human infections with adenoviruses are self-limiting in immunocompetent hosts with evidence of some persistence in adenoid tissue. we sought to better understand the natural history of adenovirus infections in various non-human primates and discovered that healthy populations of great apes (chimpanzees, bonobos, gorillas, and orangutans) and maca ... | 2009 | 19578438 |
| isolation of a novel monkey adenovirus reveals a new phylogenetic clade in the evolutionary history of simian adenoviruses. | adenoviruses of primates include human (hadv) and simian (sadv) isolates classified into 8 species (human adenovirus a to g, and simian adenovirus a). in this study, a novel adenovirus was isolated from a colony of cynomolgus macaques (macaca fascicularis) and subcultured in vero cells. its complete genome was purified and a region encompassing the hexon gene, the protease gene, the dna binding protein (dbp) and the 100 kda protein was amplified by pcr and sequenced by primer walking. sequence a ... | 2011 | 21414228 |
| host and viral traits predict zoonotic spillover from mammals. | the majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, hiv, ebola and sars). understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals for pandemic surveillance programs. however, few analytical tools exist to identify which host species are likely to harbour the next human virus, or which viruses can cross species ... | 2017 | 28636590 |