| an evaluation of the putative human mammary tumour retrovirus associated with peripheral blood monocytes. | the primary aims of this study were purification and molecular cloning of a putative retrovirus designated human mammary tumour virus (hmtv). however, our preliminary unpublished data of negative reverse transcriptase (rt) activity in ostensibly 'infected' cells led us to re-examine the evidence for this virus; namely multinucleate giant cell (mngc) formation and rt activity in cultured blood monocytes from breast cancer patients versus benign breast tumour and normal control subjects. mngcs fro ... | 1991 | 1708675 |
| of mice, cats, and men: is human breast cancer a zoonosis? | mouse mammary tumor virus (mmtv), a member of the betaretroviridae, is the most common cause of breast cancer (bc) in mice. mmtv is transmitted in mice both in the germline as endogenous proviruses and exogenously as infectious virions. here, we review a variety of evidence accumulated for six decades that has suggested that a human homologue of mmtv may exist. the findings include recent studies from several independent laboratories that have detected sequences very closely related to mmtv in d ... | 2005 | 16276516 |
| characterization of viral particles isolated from primary cultures of human breast cancer cells. | the association of human breast cancer with sequences similar to the mouse mammary tumor virus (mmtv) has been shown, but convincing evidence for the presence of viral particles in breast tumors has been lacking. we have described the complete proviral structure of a retrovirus in human breast cancer. this provirus, designated as human mammary tumor virus (hmtv), was 95% homologous to mmtv and revealed features of a replication-competent virus. we have therefore investigated the production of vi ... | 2007 | 17875739 |
| detection of human mammary tumor virus proteins in human breast cancer cells. | mouse mammary tumor virus (mmtv) has been proven to induce mammary cancer in mice. mmtv-like env gene sequences have been detected in one-third of the human breast tumors studied. the whole proviral structure with 95% homology to mmtv was found in two human breast tumors and was designated as human mammary tumor virus (hmtv). hmtv viral particles with betaretroviral features have been isolated. in addition, a retrovirus called human betaretrovirus (hbrv), homologous to the mentioned retroviruses ... | 2010 | 19781575 |